Glycosaminoglycan prevents hyperglycemia-induced renal TGF-β1 gene expression

Nephrology Dialysis Transplantation

Volumn 14, Issue SUPPL. 4, 1999, Pages 20-21

  Gambaro, G ^a   Ceol, M ^a,b   Facchin, S ^a,b   Baggio, B ^a   Weigert, C ^b   Schleicher, E D ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOSAMINOGLYCAN; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; GENE ACTIVATION; GENE EXPRESSION; HYPERGLYCEMIA; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; GENE EXPRESSION REGULATION; GLOMERULAR MESANGIUM; GLYCOSAMINOGLYCANS; HYPERGLYCEMIA; SWINE; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032795915     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/14.suppl_4.20     Document Type: Conference Paper

References (6)

1. Gambaro G, Venturini AP, Noonan DM et al. Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy. Kidney Int 1994; 46: 797-806
2. Ceol MA, Nerlich A, Baggio B et al. Increased glomerular α1 (IV) collagen expression and deposition in long-term diabetic rats is prevented by chronic glycosaminoglycan treatment. Lab Invest 1996; 4: 484-495
3. Sharma K, Ziyadeh FN. Hyperglycemia and diabetic kidney disease. The case for transforming growth factor β as a key mediator. Diabetes 1995; 44: 1139-1146
4. Kolm V, Sauer U, Nerlich A, Lehmann R, Schleicher ED. High glucose-induced transforming growth factor β1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells. J Clin Invest 1998; 101: 160-169
5. Gambaro G, Cavazzana AO, Luzi P et al. Glycosaminoglycans prevent morphological renal alterations and albuminuria in diabetic rats. Kidney Int 1992; 42: 285-291
6. Solini A, Vergnani L, Ricci F, Crepaldi G. Glycosaminoglycans delay the progression of nephropathy in NIDDM. Diabetes Care 1997; 20: 813-817