Vasodilating effect of benidipine hydrochloride in the renal and hindquarter vascular regions (supplied by terminal aorta) of spontaneously hypertensive rats

General Pharmacology

Volumn 33, Issue 2, 1999, Pages 127-136

  Teranishi, Yasuhiro ^a   Ozono, Ryoji ^a   Yoshimizu, Atsunori ^a   Ueda, Atsushi ^a   Kurisu, Satoshi ^a   Tsuru, Hiromichi ^b  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Benidipine; Calcium antagonist; Hindquarter resistance; Renal resistance; SHR; Skeletal muscle vascular resistance

Indexed keywords

BENIDIPINE; NIFEDIPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; DOSE RESPONSE; HINDLIMB; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY BLOOD FLOW; KIDNEY VASCULAR RESISTANCE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; VASCULAR RESISTANCE;

ANIMALS; BLOOD PRESSURE; DIHYDROPYRIDINES; HEART RATE; HINDLIMB; INJECTIONS, INTRAVENOUS; MALE; NIFEDIPINE; RATS; RATS, INBRED SHR; RATS, WISTAR; REGIONAL BLOOD FLOW; RENAL CIRCULATION; VASCULAR RESISTANCE; VASODILATOR AGENTS;

EID: 0032795361     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(99)00003-8     Document Type: Article

References (21)

1. Clozel J. Effects of nitrendipine and cilazapril alone or in combination on hemodynamics and regional blood flows in conscious spontaneously hypertensive rats. J Cardiovasc Pharmacol. 12:1988;600-607.
2. Ferario C.M., Page I.H. Current views concerning cardiac output in the genesis of experimental hypertension. Circ Res. 43:1978;821-831.
3. Harashima H., Kiwada H., Kajita J., Kobayashi S. Effects of benidipine hydrochloride (Coniel), a new calcium antagonist, on the cardiac output, regional blood flow and vascular resistance in conscious spontaneously hypertensive rats. Biopharmaceutics Drug Disposition. 15:1994;431-438.
4. Iriuchijima J. Mechanism of elevation of hindquarter vascular resistance in spontaneously hypertensive rats. Jpn J Physiol. 35:1985;45-56.
5. Iriuchijima J. Regional distribution of sympathetic vasoconstrictor tone in conscious spontaneously hypertensive rats. Jpn J Physiol. 36:1986;1101-1111.
6. Iriuchijima J. Abnormal hindquarter vasoconstrictor tone, a feature common to various kinds of hypertensive rats. Jpn J Physiol. 38:1988;545-548.
7. Iriuchijima J., Teranishi Y. Cardiac output in conscious and almost unrestrained spontaneously hypertensive rats. Hiroshima J Med Sci. 31:1982;259-265.
8. Iriuchijima J. Regional blood flow in conscious spontaneously hypertensive rats. Jpn J Physiol. 33:1983;41-50.
9. Karasawa A., Kubo K., Oka T., Nakamizo N. Effects of the new calcium antagonist benidipine hydrochloride on cardiohemodynamics in anesthetized dogs. Arzneim-Forsch/Drug Res. 38:1988;1713-1716. a.
10. Karasawa A., Ikeda J., Yamada K., Kubo K., Oka T., Nakamizo N. Anti-hypertensive effects of the new calcium antagonist benidipine hydrochloride in conscious, renal hypertensive dogs. Arzneim-Forsch/Drug Res. 38:1988;1695-1701. b.
11. Karasawa A., Kubo K., Shuto K., Nakamizo N. Vasodilating effects of the new calcium antagonist benidipine hydrochloride in anesthetized dogs and cats. Arzneim-Forsch/Drug Res. 38:1988;1707-1712. c.
12. Karasawa A., Kubo K., Shuto K., Oka T., Nakamizo N. Antihypertensive effects of the new calcium antagonist benidipine hydrochloride in rats. Arzneim-Forsch/Drug Res. 38:1988;1684-1690. d.
13. Karasawa A., Kubo K., Oka T., Nakamizo N. Antihypertensive effects of intravenous administration of benidipine hydrochloride and some other calcium antagonist in conscious, spontaneously hypertensive rats. Arzneim-Forsch/Drug Res. 38:1988;1691-1694. e.
14. Kenjirou K. Effects of benidipine hydrochloride on renal arterioles. Ther Res. 15:1994;2337-2340.
15. Kubo K., Karasawa A., Shuto K., Nakamizo N. Antihypertensive effects of a novel dihydropyridine-type Ca antagonist, KW-3049. Jpn J Pharmacol. 39(Suppl.):1985;217P.
16. Shimamoto H., Shimamoto Y. Benidipine counteracts sodium-induced alterations in systemic and regional hemodynamics. Blood Press. 6:1997;18-23.
17. Smith T.L., Hutchins P.M. Central hemodynamics in the developmental stage of spontaneous hypertension in the unanesthetized rats. Hypertension. 1:1979;508-511.
18. Terada K., Nakao K., Okabe K., Okabe K., Kitamura K., Kuriyama H. Action of the 1,4-dihydropyridine derivative, KW-3049, on the smooth muscle membrane of the rabbit mesenteric artery. Br J Pharmacol. 92:1987;615-625.
19. Teranishi Y., Iriuchijima J. Sympathetic vasoconstrictor tone induced by pentobarbital anesthesia in hindquarters of rats. Jpn J Physiol. 42:1992;171-178.
20. Teranishi Y., Iriuchijima J. Hindquarter vascular resistance as compensator for hypotension in conscious rats. Tohoku J Exp Med. 173:1994;283-289.
21. Teranishi Y., Iriuchijima J. Hindquarter sympathetic tone induced by small blood loss in conscious rats. Tohoku J Exp Med. 182:1997;69-73.