Polymorphic CAG repeats of the androgen receptor gene and rheumatoid arthritis

Annals of the Rheumatic Diseases

Volumn 58, Issue 8, 1999, Pages 500-502

  Kawasaki, Taku ^a   Ushiyama, Toshio ^a   Ueyama, Hisao ^a   Inoue, Koji ^a   Mori, Kanji ^a   Ohkubo, Iwao ^a   Hukuda, Sinsuke ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; MICROSATELLITE DNA; RHEUMATOID FACTOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DETERMINATION; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PATHOGENESIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RHEUMATOID NODULE; SEX DIFFERENCE; TRANSACTIVATION; TRINUCLEOTIDE REPEAT;

EID: 0032795038     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.58.8.500     Document Type: Article

References (16)

1. 1 Masi AT. Sex hormones and rheumatoid arthritis; cause and effect relationship in a complex pathophysiology? Clin Exp Rheumatol 1995;13:227-40.
2. 2 Cutolo M, Accardo S, Sex hormones, HLA and rheumatoid arthritis. Clin Exp Rheumatol 1991;9;641-6.
3. 3 Cutolo M, Masi AT. Do androgens influence the pathophysiology of rheumatoid arthritis? Facts and hypothesis. J Rheumatol 1998;25:1041-7.
4. 4 Cutolo M. Do sex hormones modulate the synovial macrophages in rheumatoid arthritis? Ann Rheum Dis 1997;56: 281-6.
5. 5 Silman AJ, MacGregor AJ, Thomson W, Holligan S, Carthy D, Farhan A, et al. Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br J Rheumatol 1993;32:903-7.
6. 6 Ollier W, Spector T, Silman A, Perry L, Ord J, Thomson W, et al. Are certain HLA haplotypes responsible for low testosterone levels in males? Dis Markers 1989;7:139-43.
7. 7 Ivanyi P, Hampl R, Starka L, Mickova M. Genetic association between II-2 gene and testosterone metabolism in mice. Nature New Biol 1972;238:281-2.
8. 8 Chamberlain NI, Driver ED, Miesfeld RL. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res 1994;22:3181-6.
9. 9 Mhatre AN, Trifiro MA, Kaufman M, Kazemi-Esfarjani P, Figlewicz D, Rouleau G, et al. Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy. Nature Genet 1993,5:184-8.
10. 10 Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
11. 11 Irvine RA, Yu MC, Ross RK, Coetzee GA. The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. Cancer Res 1995;55:1937-40.
12. 12 Ushiyama T, Mori K, Inoue K, J Huang, J Noshioka, Hukuda S. Asociation of estrogen receptor gene polymorphisms with age at onset of rheumatoid arthritis. Ann Rheum Dis 1999;58:7-10.
13. 13 Payne AH. Hormonal regulation of cytochrome P450 enzymes, cholesterol side-chain cleavage and 17a hydroxylase/C17-20 lyase in Leydig cells. Biol Reprod 1990;42:399-404.
14. 14 Roselli CE, Resko JA. Sex differences in androgen-regulated expression of cytochrome P450 aromatase in the rat brain. J Steroid Biochem Mol Biol 1997;61:365-74.
15. 15 Stanford JL, Just JJ, Gibbs M, Wicldund KG, Neal CL, Blumenstein BA, et al. Polymorphic repeats in the androgen receptor gene: Molecular markers of prostate cancer risk. Cancer Res 1997;157:1194-8.
16. 16 Giovannucci E, Stampfer M, Krithivas K, Brown M, Brufsky A, Talcott J, et al. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc Natl Acad Sci USA 1997;94:3320-3.