Uptake, tissue distribution, and excretion of brevetoxin 3 administered to rats by intratracheal instillation

Journal of Toxicology and Environmental Health - Part A

Volumn 57, Issue 5, 1999, Pages 345-355

  Benson, Janet M ^a   Tischler, Doris L ^a   Baden, Daniel G ^b  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREVETOXIN; NEUROTOXIN; SEA WATER;

ADIPOSE TISSUE; AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD; BRAIN; BRONCHOSPASM; CARCASS; CONTROLLED STUDY; DINOFLAGELLATE; EXCRETION; FECES LEVEL; INTESTINE; KIDNEY; LIVER; LUNG; MALE; METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY TRACT INFLAMMATION; TIME; TISSUE DISTRIBUTION; TOXICOKINETICS; TRACHEA; URINE LEVEL;

ADIPOSE TISSUE; ANIMALS; BRAIN; DINOFLAGELLIDA; ENVIRONMENTAL EXPOSURE; INTESTINES; INTUBATION, INTRATRACHEAL; KIDNEY; LIVER; LUNG; MALE; MARINE TOXINS; NEUROTOXINS; OXOCINS; RATS; RATS, INBRED F344; TESTIS; TISSUE DISTRIBUTION;

ANIMALIA; DINOPHYCEAE; MAMMALIA; PTYCHODISCUS;

EID: 0032794659     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/009841099157656     Document Type: Article

References (15)

1. Altshuler, B., and Pasternack, B. 1963. Statistical measures of the lower limit of detection of a radioactivity counter. Health Phys. 9:293-298.
2. Asai, S., Krzanowski, J. J., Anderson, W. H., Mardin, D. F., Dolson, J. B., Lockey, R. F., Bukantz, S. C., and Szentivanyi, A. 1982. Effects of the toxin of red tide, Ptychodiscus brevis, on canine tracheal smooth muscle: A possible new asthma-triggering mechanism. J. Allergy Clin. Immunol. 69:418-428.
3. Baden, D. G., and Mende, T. J. 1982. Toxicity of two toxins from the Florida red tide dinoflagellate (Ptychodiscus brevis). Toxicon 20:457-461.
4. Baden, D. G., and Trainer, V. L. 1993. Mode of action of toxins and seafood poisoning. In Algal toxins in seafood and drinking water, ed. I. R. Falconer, pp. 49-74. San Diego, CA: Academic Press.
5. Bossart, G. D., Baden, D. G., Ewing, R. Y., Roberts, B., and Wright, S. D. 1998. Brevetoxicosis in manatees (Trichechus manatus latirostris) from the 1996epizootic: Gross, histologic, and immunohistochemical features. Toxicol. Pathol. 26:276-282.
6. Cattet, M., and Geraci, J. R. 1993. Distribution and elimination of ingested brevetoxin (PbTx-3) in rats. Toxicon 31:1483-1486.
7. Jeglitsch, G., Rein, K., Baden, D. G., and Adams, D. J. 1998. Brevetoinx-3(PbTx-3) and i ts derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons. J. Pharmacol. Exp. Ther. 284:516-525.
8. Kennedy, C. J., Gill, K. A., and Walsh, P. J. 1990. The effects of nifurpirinal treatment on the activities of hepatic xenobiotic transforming enzymes in the gu lf toadfish, Opsanus beta (Goode and Bean) J. Fish. Dis. 13:525-529.
9. Kennedy, C. J., Schulman, L. S., Baden, D. G., and Walsh, P. J. 1992. Toxicokinetics of brevetoxin PbTx-3in the gu lf toadfish Ospanus beta following intravenous administration. Aquat. Toxicol. 22: 3-13.
10. 63Ni in F344/N rats after intratracheal instillation of nickel sulfate solutions. Environ. Res. 43:168-178.
11. Pierce, R. H. 1986. Red tide (Ptychodiscusbrevis) toxin aerosols: A review. Toxicon 24:955-965.
12. Poli, M. A., Templeton, C. B., Thompson, W. I., and Hewetson, J. F. 1990. Distribution and elimination of brevetoxin PbTx-3in rats. Toxicon 28:903-910.
13. Tibbetts, J. 1998. Toxic tides. Environ. Health Perspect. 106:A326-A331.
14. Washburn, B. S., Vines, C. A., Baden, D. G., Hinton, D. E., and Walsh, P.J. 1996. Differential effects of brevetoxin and beta-naphthoflavone on xenobiotic metabolizing enzymes in striped bass. Aquat. Toxicol. 35:1-10.
15. Washburn, B. S., Rein, K. S., Baden, D. G., Walsh, P. J., Hinton, D. E., Tullis, K., and Denison, M. S. 1997. Brevetoxin-6(PbTx-6), a nonaromatic marine neurotoxin, i s a ligand of the aryl hydrocarbon receptor. Arch. Biochem. Biopyhys. 343:149-156.