Activation of the parapyramidal region in the ventral medulla stimulates gastric acid secretion through vagal pathways in rats

Neuroscience

Volumn 95, Issue 3, 1999, Pages 773-779

  Yang, H ^a   Yuan, P Q ^a   Wang, L ^a   Tache Y ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

5 HT; Fos; Kainate; Raphe pallidus; TRH mRNA; Vagus

Indexed keywords

SEROTONIN; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLD EXPOSURE; IMMUNOREACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN BLOOD LEVEL; SIGNAL TRANSDUCTION; STOMACH ACID SECRETION; THYROTROPIN BLOOD LEVEL; VAGOTOMY; VAGUS NERVE STIMULATION;

ANIMALS; COLD; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIC ACID; KAINIC ACID; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; NEURAL PATHWAYS; PROTO-ONCOGENE PROTEINS C-FOS; PYRAMIDAL TRACTS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEROTONIN; THYROTROPIN-RELEASING HORMONE; VAGUS NERVE;

EID: 0032794016     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(99)00490-X     Document Type: Article

References (44)

1. Abercrombie M. Estimation of nuclear population from microtome sections. Anat. Rec. 94:1946;239-247.
2. Arai I., Muramatsu M., Aihara H. Body temperature dependency of gastric regional blood flow, acid secretion and ulcer formation in restraint and water-immersion stressed rats. Jpn. J. Pharmac. 40:1986;501-504.
3. Berger M.L., Lassmann H., Hornykiewicz O. Limbic seizures without brain damage after injection of low doses of kainic acid into the amygdala of freely moving rats. Brain Res. 489:1989;261-272.
4. Berthoud H.R., Fox E.A., Powley T.L. Abdominal pathways and central origin of rat vagal fibers that stimulate gastric acid. Gastroenterology. 100:1991;627-637.
5. Bonaz B., Taché Y. Induction of Fos immunoreactivity in the rat brain after cold-restraint induced gastric lesions and fecal excretion. Brain Res. 652:1994;56-64.
6. Coyle J.T., Molliver M.E., Kuhar M.J. In situ injection of kainic acid: a new method for selectively lesioning neural cell bodies while sparing axons of passage. J. comp. Neurol. 180:1978;301-323.
7. Dragunow M., Faull R. The use of c-fos as a metabolic marker in neuronal pathway tracing. J. Neurosci. Meth. 29:1989;261-265.
8. Garrick T., Buack S., Bass P. Gastric motility is a major factor in cold restraint-induced lesion formation in rats. Am. J. Physiol. 250:1986;G191-G199.
9. Garrick T., Prince M., Yang H., Ohning G., Taché Y. Raphe pallidus stimulation increases gastric contractility via TRH projections to the dorsal vagal complex in rats. Brain Res. 636:1994;343-347.
10. Helke C.J., Capuano S., Tran N., Zhuo H. Immunocytochemical studies of the 5-HT(1A) receptor in ventral medullary neurons that project to the intermediolateral cell column and contain serotonin or tyrosine hydroxylase immunoreactivity. J. comp. Neurol. 379:1997;261-270.
11. Helke C.J., McDonald C.H., Phillips E.T. Hypotensive effects of 5-HT1A receptor activation: ventral medullary sites and mechanisms of action in the rat. J. auton. nerv. Syst. 42:1993;177-188.
12. Helke C.J., Thor K.B., Sasek C.A. Chemical neuroanatomy of the parapyramidal region of the ventral medulla in the rat. Prog. Brain Res. 81:1989;17-28.
13. Hernandez D.E., Arredondo M.E., Xue B.G., Jennes L. Evidence for a role of brain thyrotropin-releasing hormone (TRH) on stress gastric lesion formation in rats. Brain Res. Bull. 24:1990;693-695.
14. Hornby P.J., Rossiter C.D., White R.L., Norman W.P., Kuhn D.H., Gillis R.A. Medullary raphe: a new site for vagally mediated stimulation of gastric motility in cats. Am. J. Physiol. 258:1990;G637-G647.
15. Hornby P.J., Sivarao D.V., Paul D. Medullary raphe and regulation of gastric function. Neurogastroenterol. Motil. 10:1998;355.
16. Kachidian P., Poulat P., Marlier L., Privat A. Immunohistochemical evidence for the coexistence of substance P, thyrotropin-releasing hormone, GABA, methionine-enkephalin, and leucin-enkephalin in the serotonergic neurons of the caudal raphe nuclei: a dual labeling in the rat. J. Neurosci. Res. 30:1991;521-530.
17. Kaneko H., Kaunitz J., Taché Y. Vagal mechanisms underlying gastric protection induced by chemical activation of raphe pallidus in rats. Am. J. Physiol. 275:1998;G1056-G1062.
18. Kaneko H., Taché Y. TRH in the dorsal motor nucleus of vagus is involved in gastric erosion induced by excitation of raphe pallidus in rats. Brain Res. 699:1995;97-102.
19. Kaneko H., Yang H., Ohning G., Taché Y. Medullary TRH is involved in gastric protection induced by low dose of kainic acid into the raphe pallidus. Am. J. Physiol. 268:1995;G548-G552.
20. Krowicki Z.K. Role of selected peptides in the vagal regulation of gastric motor and endocrine pancreatic function. J. Physiol. Pharmac. 47:1996;399-409.
21. Krukoff T.L. Expression of c-fos in studies of central autonomic and sensory systems. Molec. Neurobiol. 7:1993;247-263.
22. Lee S.L., Stewart K., Goodman R.H. Structure of the gene encoding rat thyrotropin releasing hormone. J. biol. Chem. 263:1988;16,604-16,609.
23. Luo L.G., Jackson I.M. Antisense oligomers of cfos and cjun block glucocorticoid stimulation of thyrotropin-releasing hormone (TRH) gene expression in cultured anterior pituitary cells. Peptides. 19:1998;1295-1302.
24. Lynn R.B., Kreider M.S., Miselis R.R. Thyrotropin-releasing hormone-immunoreactive projections to the dorsal motor nucleus and the nucleus of the solitary tract of the rat. J. comp. Neurol. 311:1991;271-288.
25. Martinez V., Wu S.V., Taché Y. Intracisternal antisense oligodeoxynucleotides to the TRH receptor blocked vagal dependent stimulation of gastric emptying induced by acute cold in rats. Endocrinology. 139:1998;3730-3735.
26. McCann M.J., Hermann G.E., Rogers R.C. Nucleus raphe obscurus (nRO) influences vagal control of gastric motility in rats. Brain Res. 486:1989;181-184.
27. McCann M.J., Hermann G.E., Rogers R.C. Thyrotropin-releasing hormone: effects on identified neurons of the dorsal vagal complex. J. auton. nerv. Syst. 26:1989;107-112.
28. McTigue D.M., Rogers R.C., Stephens R.L.J. Thyrotropin-releasing hormone analogue and serotonin interact within the dorsal vagal complex to augment gastric acid secretion. Neurosci. Lett. 144:1992;61-64.
29. Morgan J.I., Curran T. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. A. Rev. Neurosci. 14:1991;421-451.
30. Niida H., Takeuchi K., Okabe S. Role of thyrotropin-releasing hormone in acid secretory response induced by lowering of body temperature in the rat. Eur. J. Pharmac. 198:1991;137-142.
31. Niida H., Takeuchi K., Ueshima K., Okabe S. Vagally mediated acid hypersecretion and lesion formation in anesthetized rat under hypothermic conditions. Dig. Dis. Sci. 36:1991;441-448.
32. Paxinos G. and Watson C. (1997) The Rat Brain in Stereotaxic Coordinates, pp. 1-116. Academic, Orlando.
33. Sasek C.A., Wessendorf M.W., Helke C.J. Evidence for co-existence of thyrotropin-releasing hormone, substance P and serotonin in ventral medullary neurons that project to the intermediolateral cell column in the rat. Neuroscience. 35:1990;105-119.
34. Seely E. W. and Williams G. H. (1990) Gastrointestinal manifestations of endocrine disease. In Principles and Practice of Endocrinology and Metabolism (ed. Becker K. L.), pp. 1503-1506. J. B. Lippincott, Philadelphia.
35. Seely E. W. and Williams G. H. (1990) The cardiovascular system and endocrine disease. In Principles and Practice of Endocrinology and Metabolism (ed. Becker K. L.), pp. 1496-1501. J. B. Lippincott, Philadelphia.
36. Taché Y., Yang H., Kaneko H. Caudal raphe-dorsal vagal complex peptidergic projections: role in gastric vagal control. Peptides. 16:1995;431-435.
37. Thor K.B., Helke C.J. Serotonin- and substance P-containing projections to the nucleus tractus solitarii of the rat. J. comp. Neurol. 265:1987;275-293.
38. Wang L., Cardin S., Martinez V. Intracerebroventricular CRF inhibits cold restraint-induced c-fos expression in the dorsal motor nucleus of the vagus and gastric erosions in rats. Brain Res. 736:1996;44-53.
39. Yang H., Ohning G.V., Taché Y. TRH in dorsal vagal complex mediates acid response to excitation of raphe pallidus neurons in rats. Am. J. Physiol. 265:1993;G880-G886.
40. Yang H., Taché Y. Substance P in the dorsal vagal complex inhibits medullary TRH-induced gastric acid secretion in rats. Am. J. Physiol. 272:1997;G987-G993.
41. Yang H., Wu S.V., Ishikawa T., Taché Y. Cold exposure elevates thyrotropin-releasing hormone gene expression in medullary raphe nuclei: relationship with vagally mediated gastric erosions. Neuroscience. 61:1994;655-663.
42. Yang H., Zhang X. J., Tache Y., Yoneda M. and Wang C. C. (1995) Central serotonin influences the development of cold-restraint stress-induced gastric ulceration: role of autonomic and endocrine mechanisms. In Gastrointestinal Tract and Endocrine System (eds Singer M. V., Ziegler R. and Rohr G.), pp. 77-82. Kluwer Academic, London.
43. Yoneda M., Taché Y. Serotonin enhances gastric acid response to TRH analogue in dorsal vagal complex through 5-HT2 receptors in rats. Am. J. Physiol. 269:1995;R1-R6.
44. Yuan P.Q., Yang H. Hypothyroidism induces Fos-like immunoreactivity in ventral medullary neurons that synthesize TRH. Am. J. Physiol. 277:1999;E927-E936.