Can traditional epidemiology detect cancer risks caused by occupational exposure to pesticides?

Journal of Experimental and Clinical Cancer Research

Volumn 18, Issue 2, 1999, Pages 159-166

  Georgellis, A ^a   Kolmodin Hedman, B ^b   Kouretas, D ^c  

^a Environ Illness Research Center   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF THESSALY   (Greece)

Author keywords

Cancer risk; Environment; Occupational epidemiology; Occupational exposure; Pesticides; Pollutants

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; BENOMYL; CAPTAN; CHLOROPHENOL; CHLORPHENOTANE; DICHLORVOS; FOLPET; FUNGICIDE; INSECTICIDE; LINDANE; METHOXYCHLOR; PESTICIDE; PYRETHROID; QUINTOZENE; SULFUR;

ANALYTIC METHOD; ARTICLE; BRAIN CANCER; CANCER EPIDEMIOLOGY; CANCER RISK; DIGESTIVE SYSTEM CANCER; DISEASE ASSOCIATION; GONAD TUMOR; HUMAN; LEUKEMIA; MEDICAL LITERATURE; OCCUPATIONAL CANCER; OCCUPATIONAL CARCINOGENESIS; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; RESPIRATORY TRACT CANCER; RISK ASSESSMENT; SOFT TISSUE CANCER; XENOBIOTIC METABOLISM;

HUMANS; NEOPLASMS; OCCUPATIONAL DISEASES; PESTICIDES; RISK FACTORS;

EID: 0032793754     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (77)

1. IARC: Monographs on the evaluation of carcinogenic risks to humans. Overall evaluations of carcinogenicity: An uppdating of IARC Monographs Vols 1-42. Suppl 7. Lyon, France, International Agency for Research on Cancer, 1987.
2. IARC: Monographs on the evaluation of carcinogenic risks to humans. Vols 53. Lyon, France, International Agency for Research on Cancer, 1991.
3. Hayes W.J., Laws E.R.: Handbook of pesticide toxicology. Academic Press Inc.,1991.
4. World Watch Institute: Worldwatch Institute Report 88/89. W. W. Norton & Company, New York, 1988, 200-240.
5. Petrelli G., Siepi G., Miligi L., Vineis P.: Solvents in pesticides. Scand. J. Work Environ. Health. 19: 63-65,1993.
6. Idle J.R.: Is environmental carcinogenesis modulated by host polymorphism? Mutat. Res. 247: 259-266,1991.
7. Nebert D.W. : Role of genetics and drug metabolism in human cancer risk. Mutat. Res. 247: 267-281,1991.
8. Omenn G.S.: Future research directions in cancer ecogenetics. Mutat. Res. 247: 283-291,1991.
9. Vesell E.S.: Genetic and environmental factors causing variation in drug response. Mutat. Res. 247: 241-257,1991.
10. Hollstein M., Sidransky D., Vogelstein B., Harris C.C.: p53 mutations in human cancers. Science 253: 49-53,1991.
11. Knudson A.G. Jr.: Overview: genes that predispose to cancer. Mutat. Res. 247: 185-190,1991.
12. Nebert D.W., Petersen D.D., Puga A.: Human AH locus polymorphism and cancer: inducibility of CYP 1A1 and other genes by combustion products and dioxin. Pharmacogenetics 1: 68-78,1991.
13. Hardell L., Sandstrom A.: Case-control study: Soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols Br. J. Cancer 39: 711-717,1979.
14. Eriksson M., Hardell L., Berg N.O., Moller T., Axelson O.: Soft-tissue sarcomas and exposure to chemical substances: A case referent study. Br. J. Ind. Med. 38: 27-33,1981.
15. Hardell L., Eriksson M., Lenner P., Lundgren E.: Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: a case-control study. Br. J. Cancer 43: 169-176,1981.
16. Honchar P.A., Halperin W.A.: 2,4,5-T,trichlorophenol and soft-tissue sarcoma. Lancet 1: 268-269,1981.
17. Cantor K.P.: Farming and mortality from non-Hodgkin's lymphoma: A case-control study. Int. J. Cancer 29: 239-247,1982.
18. Buesching D.P., Wollstadt L.: Cancer mortality among farmers. J. Natl. Cancer Inst. 72: 503,1984.
19. Axelson O.: Pesticides and cancer risks in agriculture. Med. Oncol. Tumor Pharmacoth. 374: 207-217,1987.
20. Bond G.G., Bodner K.M., Cook R.R.: Phenoxy herbicides and cancer: insufficient evidence for a causal relationship. Fund. Appl. Tox. 12: 172-188,1989.
21. Wingren G., Fredrikson M., Noorlind Brage H., Nordenskj_ld B., Axelson O.: Soft tissue sarcoma and occupational exposures. Cancer 66: 806-811,1990.
22. Lilienfeld D.E., Gallo M.A.: 2,4-D, 2,4,5-T, and 2,3,7,8-TCDD: An overview. Epidemiol. Rev. 11: 28-58,1989.
23. Huff J.E., Salmon A.G., Hooper N.K. , Zeise L.: Long-term carcinogenesis studies on 2,3,7,8,-tetrachlorodibenzo-p-dioxin and hexachlorodibenzo-p-dioxins. Cell. Biol. Toxicol. 7: 67-94,1991.
24. Wiklund K., Holm L.E.: Soft tissue sarcoma risk in Swedish agricultural and forestry workers. J. Natl. Cancer Inst. 76: 229-234,1986.
25. Kolmodin-Hedman B., Akerblom M.: Monitoring of humans for occupational exposure to herbicides. In: Hutson DH Roberts (eds) Herbicides. John Wiley & Sons Ltd , 1987,199-222.
26. Wiklund K., Dick J., Holm L.E.: Soft tissue sarcoma risk in Swedish licensed pesticides applicators. J. Occup. Med. 30: 801-804,1988.
27. Coggon D., Pannett B., Winter P.: Mortality and incidence of cancer at four factories making phenoxy herbicides. Br. J. Ind. Med. 48: 173-178,1991.
28. Saracci R., Kogevinas M., Bertazzi P.-A. et al: Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols. Lancet 338: 1027-1032,1991.
29. Bueno de Mesquita B.H., Doornbos G., van der Kuip D.A.M., Kogevinas M., Winkelmann R.: Occupational exposure to phenoxy herbicides and chlorophenols and cancer mortality in the Netherlands. Am. J. Ind. Med. 23: 289-300,1993.
30. Hoar Zahm S., Weisenburger D.D., Cantor K.P., Holmes F.F., Blair A.: Role of the herbicide atrazine in the development of non-Hodgkin's lymphoma. Scand. J. Work Environ. Health 19: 108-114,1993.
31. Bond G.G., Rossbacher R.: A review of potential human carcinogenicity of the chlorophenoxy herbicides MCPA, MCPP, and 2,4-DP. Br. J. Ind. Med. 50: 340-348,1993.
32. Kogevinas M., Saracci R., Winkelmann R. et al: Cancer incidence and mortality in women occupationally exposed to chlorophenoxy herbicides, chlorophenols, and dioxins. Cancer Causes and Control 4: 547-553,1993.
33. Wiklund K., Dich J., Holm L.E.: Risk of malignant lymphoma in Swedish pesticide appliers. Br. J. Cancer 56:505-508,1987.
34. Wiklund K., Dick J., Holm L.E., Eklund G.: Risk of cancer in pesticide applicators in Swedish agriculture. Br. J. Ind. Med. 46: 809-814,1989.
35. Corrao G., Calleri M., Carle F., Russo R., Bosia S., Piccioni P.: Cancer risk in a cohort of licenced pesticide users. Scand. J. Work Environ. Health 15: 203-209,1989.
36. Wigle D.T., Semenciw R.M., Whilkins K. et al: Mortality study of Canadian male farm operators: non Hodgkin''s lymphoma mortality and agricultural practices in Sakatchewan. J. Natl. Cancer Inst. 82: 575-582,1990.
37. Pearce N., Reif J.: Epidemiologic studies of cancer in agricultural workers. Am. J. Ind. Med. 18: 133-148,1990.
38. Woods J.S., Polissar L., Severson R.K., Heuser L.S., Kulander B.G.: Soft tissue sarcoma and non-Hodgkin''s lymphoma in relation to phenoxyherbicide and chlorinated phenol exposure in Western Washington. J. Natl. Cancer Inst. 78: 899-910,1987.
39. Blair A., Malker H., Cantor K.P., Burmeister L., Wiklund K.: Cancer among farmers. A review. Scand. J. Work Environm. Health 11: 397-407,1985.
40. Cordier S., Poisson M., Gerin M., Varin J., Conso F., Hemon D.: Gliomas and exposure to wood preservatives. Br. J. Ind. Med. 45: 705-709,1988.
41. Musicco M., Sant M., Molinari S., Filippini G., Gatta G., Berrino F.: A case-control study of brain gliomas and occupational exposure to chemical carcinogens: The risk to farmers. Am. J. Epidemiol. 128: 778-785,1988.
42. Khuder S.A., Mutgi A.B., Schaub E.A.: Meta-analyses of brain cancer and farming. Am. J. Ind. Med. 34(3): 252-260,1998.
43. Littorin M., Attewell R., Skerfving S., Horstmann V., Moller T.: Mortality and tumor morbidity among Swedish market gardeners and orchardists. Int .Arch. Occup. Environ. Health 65: 163-169,1993.
44. Swenberg J.A.: Current approaches to the experimental investigation of chemicals in relation to cancer of the brain. Ann. N.Y. Acad. Sci. 381: 43-49,1982.
45. Roeleveld N., Zielhuis G.A., Gabreels F.: Occupational exposure and defects of the central nervous system in offspring: review. Br. J. Ind. Med.47: 580-588,1990.
46. O'Leary L.M., Hicks A.M., Peters J.M., London S.: Parental occupational exposures and risk of childhood cancer: a review. Am. J. Ind. Med. 20: 17-35,1991.
47. Gold E., Gordis L., Tonascia J., Szklo M.: Risk factors for brain tumors in children. Am. J. Epidemiol. 109: 309-319, 1979.
48. Gold E.B., Diener M.D., Szklo M.: Parental occupations and cancer in children. J. Occup. Med. 24: 578-584,1982.
49. Wilkins J.R., Koutras R.A.: Parental occupation and brain cancer in offspring: A mortality-based case-control study. Am. J. Ind. Med. 14: 299-314,1988.
50. Flodin U., Fredriksson M., Persson B., Axelson O.: Chronic lymphatic leukemia and engine exhausts, fresh wood and DDT: a case-referent study. Br. J. Ind. Med. 45: 33-38,1988.
51. Persson B., Dahlander A.-M., Fredriksson M., Noorlind Brage H., Ohlson C.-G., Axelson O.: Malignant lymphomas and occupational exposures. Br. J. Ind. Med. 46: 516-520,1989.
52. Brown L.M., Blair A., Gibson R. et al: Pesticide exposure and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Res. 50: 6585-6591,1990.
53. Viel J.-F., Richardson S.T.: Adult leukemia and farm practices: an alternative approach for assessing geographical pesticide exposure. Soc. Sci. Med. 32: 1067-1073,1991.
54. Buckley J.D., Robison L.L., Swotinsky R. et al: Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the children cancer study group. Cancer Res. 49: 4030-4037,1989.
55. Nanni O., Falcini F., Buiatti E. et al: Multiple myeloma and work in agriculture : results of a case-control study in Forli, Italy. Cancer Causes Control 9(3): 277-283,1998.
56. Hardell L., Bengtsson N.O., Eriksson S., Larsson L.G.: Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria-an epidemiological investigation. Br. J. Cancer 50: 389-394,1984.
57. Van D.D.: Herbicides as a possible cause of liver cancer. In: Westing A.H. (ed) Herbicides in war, the longterm ecological and human consequences. London Taylor and Francis, 1984,119-121.
58. Rafnsson V., Gunnarsdottir H.: Mortality study of fertiliser manufactures in Island. Br. J. Ind. Med. 47: 721-725,1990.
59. Ronco G., Costa G., Lynge E.: Cancer among Danish and Italian farmers. Br. J. Ind. Med. 49: 220-225,1992.
60. Wiklund K., Steineck G.: Cancer in the respiratory organs of Swedish farmers. Cancer 61: 1055-1058,1988.
61. Bravo M.P, Espinosa J., del Rey Calero J.: Occupational risk factors for cancer of the larynx in Spain. Neoplasma 37: 477-481,1990.
62. Sathiakumar N., Delzell E., Austin H., Cole P.: A follow-up study of agricultural chemical production workers. Am. J. Ind. Med. 21: 321-330,1992.
63. Stottrup Hansen E., Hasle H., Lander F.: A cohort study on cancer incidence among Danish gardeners. Am. J. Ind. Med. 21: 651-660,1992.
64. Blair A., Cantor K.P., Zahm S.H.: Non-Hodgkin's lymphoma and agricultural use of the insecticide lindane. Am. J. Ind. Med. 33(1): 82-87, 1998.
65. Van Den Eeden S., Weiss N.S., Strader C.H., Dalling J.R.: Occupation and the occurence of testicular cancer. Am. J. Ind. Med. 19: 327-337,1991.
66. Sewell C.M., Castle S.P., Hull H.F., Wiggins C.: Testicular cancer and employment in agriculture and oil and natural gas extraction (Letter). Lancet 1: 553,1986.
67. Olsen J.H., Jensen O.M.: Occupation and risk of cancer in Denmark: an analysis of 93,810 cancer cases, 1970-1979. Scand. J. Work Environ. Health (Suppl. 1) 13: 7-91,1987.
68. Cocco P., Benichou J.: Mortality from cancer of the male reproductive tract and environmental exposure to the anti-androgen p,p'-dichlorophenyldichloroethylene in the United States. Oncology 55(4): 334-339,1998.
69. Donna A., Crosignani P., Robutti F. et al: Triazine herbicides and ovarian epithelial neoplasms. Scand. J. Work Environ. Health 15:47-53,1989.
70. Sathiakumar N., Delzell E. : A review of epidemiologic studies of triazine herbicides and cancer. Crit. Rev. Toxicol. 27(6): 599-612,1997.
71. Maroni M., Fait A.: Monograph: Health effects in man from long-term exposure to pesticides. Toxicology, Vol 78,1993.
72. Dich J., Wiklund K.: Prostate cancer in pesticide applicators in Swedish agriculture. Prostate 34(2): 100-112,1998.
73. Roe F.J.C.: Should we listen to granny or to the risk extrapolators? Indoor Environ. 1: 41-43,1992.
74. Kolmodin-Hedman B., S_derman E., Georgellis A., Dich J., Wiklund K. : Cancerrisker hos svenska skadedjurssanerare. In: 42:a Nordiska Arbetsmilj_m_tet, Viby/Sweden, 1993,62.
75. Dich J., Zahm S.H., Hanberg A., Adami H.O.: Pesticides and cancer. Cancer Causes Control 8(3): 420-443,1997.
76. Schulte P.A., Perera F.P.: Molecular epidemiology: principles and practices. Academic Press Inc,1993.
77. Hemminki K.: Interindividual variations in the level of DNA and protein adducts in humans. Ecogenetics 1: 217-234, 1991.