Generation of autologous immunity to acute myeloid leukaemia and maintenance of complete remission following interferon-α treatment

Cytokines, Cellular and Molecular Therapy

Volumn 5, Issue 2, 1999, Pages 119-121

  Lowdell, Mark W ^a   Craston, Rose ^a   Grant Prentice, H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Acute leukaemia; Cell mediated cytotoxicity; Immunotherapy; Interferon ; NK cells

Indexed keywords

RECOMBINANT ALPHA2A INTERFERON;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; CANCER CHEMOTHERAPY; CANCER IMMUNOLOGY; CASE REPORT; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; FEMALE; FEVER; HEADACHE; HUMAN; HUMAN CELL; LEUKEMIA REMISSION; PRIORITY JOURNAL; RELAPSE; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032792876     PISSN: 13684736     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Deane M, Koh M, Foroni L et al, FLAG/idarubicin and allogeneic stem cell transplantation for Ph positive ALL beyond first remission. Bone Marrow Transplant (1999) 22: 1137-43.
2. Lowdell MW, Ray N, Craston R et al, The in vitro detection of anti-leukaemia-specific cytotoxicity after autologous bone marrow transplantation for acute leukaemia. Bone Marrow Transplant (1997) 19: 891-7.
3. Pierson BA, Miller JS, CD56+ bright and CD56+ dim natural killer cells in patients with chronic myelogenous leukaemia progressively decrease in number, respond less to stimuli that recruit clonogenic natural killer cells, and exhibit decreased proliferation on a per cell basis. Blood (1996) 88: 2279-87.
4. Cervantes F, Pierson BA, McGlave PB et al, Autologous activated NK cells suppress primitive chronic myelogenous leukemia progenitors in long-term culture. Blood (1996) 87: 2476-85.
5. Jewett A, Bonavida B, Interferon-alpha activates cytotoxic function but inhibits IL-2-mediated proliferation and tumor necrosis factor alpha secretion by immature natural killer cells. J Clin Immunol (1995) 15: 35-44.
6. Mehta J, Powles R, Kulkani S et al, Induction of graft-versus-host disease as immunotherapy of leukaemia relapsing after allogeneic bone marrow transplantation: single-centre experience of 32 adult patients. Bone Marrow Transplant (1997) 20: 129-35.
7. Singhal S, Powles R, Treleaven J, Mehta J, Sensitivity of secondary acute myeloid leukaemia relapsing after allogeneic bone marrow transplantation to immunotherapy with interferon-alpha 2b. Bone Marrow Transplant (1997) 19: 1151-3.
8. Giralt S, O'Brien S, Talpaz M et al, Interferon-α and interleukin-2 as treatment for relapse after allogeneic bone marrow transplantation. Cytokines Mol Ther (1995) 1: 115-22.
9. Cortes J, Kantarjian H, O'Brien S et al, GM-CSF can improve the cytogenetic response obtained with alpha-interferon therapy in patients with chronic myelogenous leukemia. Leukemia (1998) 12: 860-4.
10. Williams M, Newland AC, Kelsey SM, Monocyte-mediated killing of human leukaemia is enhanced by administration of GM-CSF following chemotherapy. Br J Haematol (1997) 98: 960-8.