Klinisches Erscheinungsbild und therapeutisches Management der schweren Intoxikation mit trizyklischen Antidepressiva

Intensivmedizin und Notfallmedizin

Volumn 36, Issue 5, 1999, Pages 462-466

  Maitra, R T ^a   Konicvek, K H ^a   Cyran, J ^a  

^a Schwerpunkt Kardiologie/Onkologic   (Germany)

Author keywords

Intoxication; Therapy; Tricyclic antidepressant drugs

Indexed keywords

TRICYCLIC ANTIDEPRESSANT AGENT;

ARTICLE; BRAIN FUNCTION; DRUG EFFECT; DRUG INTOXICATION; HEART ARRHYTHMIA; HUMAN; LUNG FUNCTION; PATHOPHYSIOLOGY;

EID: 0032792291     PISSN: 01753851     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003900050266     Document Type: Article

References (40)

1. Bickel MH (1975) Poisoning by tricyclic antidepressant drugs. General and pharmacokinetic considerations. Int J Clin Pharmacol 11: 145-176
2. Boehnert MT, Lovejoy FH (1985) Value of the QRS duration versus the serum drug level in predicting seizures and ventricular arrhythmias after an acute overdose of tricyclic antidepressants. N Engl J Med 313: 474-479
3. Callaham M, Kassel D (1985) Epidemiology of fatal tricyclic antidepressant ingestion: Implications for management. Am J Emerg Med 14: 1-9
4. Crome P (1986) Poisoning to tricyclic antidepressant overdosage. Clinical presentation and treatment. Med Toxicol 1: 261-285
5. Demling J, Flügel D (1992) Neuere Antidepressiva: Pharmakodynamik, unerwünschte Wirkungen, Wechselwirkungen und Intoxikation. Nervenheilkunde 11: 126-132
6. Ellison DW, Pental PR (1989) Clinical features and consequences of seizures due to cyclic antidepressant overdose. Am J Emerg Med 7: 5-10
7. Fasoli RA, Glauser FL (1981) Cardiac arrhythmias and ECG abnormalities in tricyclic antidepressant overdose. Clin Toxicol 18: 155-163
8. Flaherty JJ, Ceva D, Graff J (1986) ARDS associated with massive imipramine overdose. Am J Emerg Med 4: 195-197
9. Frommer DA, Kulig KW, Marx JA, Rumack B (1987) Tricyclic antidepressant overdose. A review. J Am Med Ass 257: 521-526
10. Foulke GE (1995) Identifying toxicity risk early after antidepressant overdose. Am J Emerg Med 13: 123-126
11. Glassmann AH (1984) Cardiovascular effects of tricyclic antidepressants. Ann Rev Med 35: 503-511
12. Goldberg RJ, Capone RJ, Hunt JD (1985) Cardiac complications following tricyclic antidepressant overdose. Issues for monitoring policy. J Am Med Ass 254: 1772-1775
13. Henry JA, Antao CA (1992) Suicide and fatal antidepressant poisoning. Eur J Med 1: 343-348
14. Hermann HC, Kaplan LM (1983) QT prolongation and torsades de pointes ventricular tachycardia produced by the tetracyclic depressant agent maprotiline. Am J Cardiol 51: 904-906
15. Hoffmann JR, McElroy CR (1981) Bicarbonate therapy for dysarrhythmia and hypotension in tricyclic antidepressant overdosage. West J Med 134: 60-64
16. Hollister LE (1978) Treatment of depression with drugs. Ann Intern Med 89: 78-84
17. Hultén BÁ, Adams R, Askenasi R (1992) Predicting severity of tricyclic antidepressant overdose. Clin Toxicol 30: 161-170
18. Jick SS, Dean AD, Jick H (1985) Antidepressants and suicide. Brit Med J 310: 215-218
19. Kathol RG, Henn FA (1983) Tricyclics - The most common agent used in potential lethal overdoses. J Nerv Ment Dis 171: 250-252
20. Kapur S, Mieczkowski T, Mann J (1992) Antidepressant medications and the relative risk of suicide attempt and suicide. J Amer Med Ass 268: 3441-3445
21. Keegan AD (1993) Doxepin-induced recurrent acute hepatitis. Aust NZ J Med 23: 523
22. Levitt MA, Sullivan JB, Owens SM, Burnham L, Finley PR (1986) Amitriptile plasma protein binding. Effect of plasma pH and relevance in clinical overdose. Am J Emerg Med 4: 121-125
23. Mühlendahl KE, Krienke EG, Hammersen G (1976) Physostigmintherapie bei Vergiftungen. Dtsch Med Wschr 101: 1401-1402
24. Müller WE (1992) Wirkungsmechanismen der Psychopharmaka. Dtsch Apothcker-Ztg 132: 173-182
25. Munzinger M (1984) Vergiftungen durch trizyklische Antidepressiva nehmen zu. Notfallmed 10: 333-342
26. Orr OA, Bramble UG (1981) Tricyclic antidepressant poisoning and prolonged external cardiac massage during asystole. Brit Med J 283: 1107-1108
27. Powell WJ, Koch-Weser (1968) Lethal hepatic necrosis after therapy with imipramine and desipramine. J Amer Med Ass 206: 642-645
28. Preskorn SH, Irwin HA (1982) Toxicity of Tricyclics Antidepressants - Kinetics, Mechanism, Intervention: A Review. J Clin Psychiatr 42: 151-154
29. Rasenack U, Gattenlöhner W (1976) Trizyklische Antidepressiva: Klinik und Therapie der Intoxikation. Dtsch Med Wschr 101: 1165-1168
30. Risch SC, Groom GP, Janowski DS (1982) The effects of Psychotropic Drugs on the Cardiovascular System. J Clin Psychiatr 43: Sec. 2, 16-31
31. Rosen MJ (1983) Tricyclic antidepressant overdose: clinical features and management. Heart Lung 12: 222-225
32. Scheinin M, Virtanen R, Iisalo E (1985) Effect of single and repeated doses of activated charcoal on the pharmacokinetics of doxepin. Int J Clin Pharmacol Ther Toxicol 23: 38-42
33. Sehnert W (1987) Physostigmin bei der Behandlung schwerer Intoxikationen mit trizyklischen Antidepressiva. Intensivmed Notfallmed 24: 296-300
34. Shannon M, Lovejoy FH (1987) Pulmonary consequences of severe tricyclic antidepressant ingestion. Clin Toxicol 25: 443-461
35. Spiker DG, Weiss AN, Chang SS (1975) Tricyclic antidepressant overdose: clinical presentation and plasma levels. Clin Pharmacol Ther 18: 539-546
36. Starkey IR, Lawson AA (1980) Poisoning with tricyclic and related antidepressants: a ten-year review. Quart J Med 49: 33-49
37. Thorstrand C (1976) Clinical features in poisoning by tricyclic antidepressants with special reference ot the ECG. Acta Med Scand 199: 337-344
38. Van Brunt N (1983) The clinical utility of tricyclic antidepressant blood levels: A review of the literature. Ther Drug Monit 5: 1-10
39. Vohra J, Burrows G, Hunt D, Sloman G (1975) The effect of toxic and therapeutic doses of tricyclic antidepressant drugs on intracardiac conduction. Eur J Cardiol 3: 219-227
40. Zilker T (1992) Vergiftungen durch Antidepressiva und Lithium. Intensivmed 29: Suppl. 1,72-82