The effect of butylated hydroxytoluene on selected immune surveillance parameters in rats bearing enzyme-altered hepatic preneoplastic lesions

Food and Chemical Toxicology

Volumn 37, Issue 7, 1999, Pages 671-681

  Tryphonas, H ^a   Lacroix, F ^a   Lok, E ^a   Jee, P ^a   Clayson, D B ^a   Hayward, S ^b   Miller, D ^b   Mehta, R ^a  

^a TOXICOLOGY RESEARCH DIVISION   (Canada)

^b Healthy Environments and Consumer Safety   (Canada)

Author keywords

BHT and cancer; BHT immunosurveillance; BHT immunotoxicity

Indexed keywords

BUTYLCRESOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; IMMUNOSURVEILLANCE; LEUKOCYTE; LIVER TUMOR; MALE; MONONUCLEAR CELL; NATURAL KILLER CELL; NONHUMAN; RAT; SPLEEN CELL;

ANIMALS; BUTYLATED HYDROXYTOLUENE; CALCIUM; DIET; EXUDATES AND TRANSUDATES; FOOD PRESERVATIVES; HEPATECTOMY; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; KILLER CELLS, NATURAL; LIVER NEOPLASMS, EXPERIMENTAL; LYMPHOCYTE ACTIVATION; MALE; PERITONEAL CAVITY; PHAGOCYTOSIS; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; SPLEEN;

RODENTIA;

EID: 0032791562     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(99)00054-X     Document Type: Article

References (43)

1. Appelbaum J.W. The role of the immune system in the pathogenesis of cancer. Seminars in Oncology Nursing. 8:1992;51-62.
2. Archer D.L., Smith B.G., Bukovic-Wess A. Use of an in vitro antibody-producing system for recognizing potentially immunosuppressive compounds. International Archives of Allergy and Applied Immunology. 56:1978;90-93.
3. Bolton J.L., Sevestre H., Ibe B.O., Thompson J.A. Formation and reactivity of alternative quinone methides from butylated hydroxytoluene: possible explanation for species-specific pneumotoxicity. Chemical Research in Toxicology. 3:1990;65-70.
4. Bolton J.L., Thompson J.A. Oxidation of butylated hydroxytoluene to toxic metabolites. Factors influencing hydroxylation and quinone methide formation by hepatic and pulmonary microsomes. Drug Metabolism and Disposition. 19:1991;467-472.
5. Bomhard E.M., Bremmer J.N., Herbold B.A. Review of the mutagenicity/genotoxicity of butylated hydroxytoluene. Mutation Research. 277:1992;187-200.
6. Boon T., Cerottini J-C., Van den Eynde B., Van der Bruggen P., Van Pel A. Tumor antigens recognized by T lymphocytes. Annual Review of Immunology. 12:1994;65-337.
7. Briggs D., Lok E., Nera E.A., Karpinski K., Clayson D.B. Short-term effects of butylated hydroxytoluene on the Wistar rat liver, urinary bladder and thyroid gland. Cancer Letters. 46:1989;31-36.
8. Brodt P., Lala P.K. Changes in host lymphocyte subsets during chemical carcinogenesis. Cancer Research. 43:1983;15-22.
9. Cornell R.P. Acute phase responses after acute liver injury by partial hepatectomy in rats as indicators of cytokine release. Hepatology. 11:1990;923-931.
10. Dean J.H., Ward E.C., Murray M.J., Lauer L.D., House R.V. Mechanisms of dimethylbenzanthracene-induced immunotoxicity. Clinical Physiology and Biochemistry. 3:1985;98-110.
11. Department of National Health Welfare (1981) Departmental Consolidation of the Food and Drugs Regulations with Amendments to May 3, 1990. Ministry of Supply and Services Canada, Ottawa, Ontario, Canada.
12. Fausto N., Mead J.E. Regulation of liver growth: protooncogenes and transforming growth factors. Laboratory Investigation. 60:1989;4-13.
13. Gerson J.M., Veresio L., Herberman R.B. Systemic and in situ natural killer and suppressor cell activities in mice bearing progressively growing murine sarcoma-virus-induced tumors. International Journal of Cancer. 27:1981;243-248.
14. Gimble R.F. Nutritional antioxidants and the modulation of inflammation: Theory and practice. New Horizons. 2:1994;175-185.
15. + monocytic cells in tumor stroma. International Journal of Cancer. 35:1985;199-205.
16. Hu Z., Evarts R.P., Fujio K., Marsden E.R., Thorgeirsson S. Expression of hepatocyte growth factor and c-met genes during differentiation and liver development in the rat. American Journal of Pathology. 142:1993;1823-1830.
17. Inai K., Korbuke T., Nambu S., Takemoto T., Kou E., Nishina H., Fujihara M., Yonehara S., Suehiro S., Tsuya T., Horiuchi K., Tokuoka S. Hepatocellular tumorigenicity of butylated hydroxytoluene administered orally to B6C3F1 mice. Japanese Journal of Cancer Research. 79:1988;49-58.
18. Kawabata T.T., White K.L. Suppression of the in vitro humoral immune response of mouse splenocytes by benzo(a)pyrene metabolites and inhibition of benzo(a)pyrene-induced immunosuppression by β-naphthoflavone. Cancer Research. 47:1987;2317-2322.
19. Kim D-H., Yang K-H., Johnson K.W., Holsapple M.P. Role of the transfer of metabolites from hepatocytes to splenocytes in the suppression of in vitro antibody response by dimethylnitrosamine. Biochemical Pharmacology. 37:1988;2765-2771.
20. Klein A., Bruser B. The effect of butylated hydroxytoluene, with and without cortisol, on stimulated lymphocytes. Life Sciences. 50:1992;883-889.
21. Leu R.W., Norton T.R., Herriot M.J., Ringer D.P., Kearnes R.J. Suppression of natural killer and lymphocyte functions associated with carcinogen-induced premalignant hyperplastic nodules in rat liver. Cancer Research. 45:1985;3282-3287.
22. Lok E., Mehta R., Jee P., Laver G., Nera E.A., McMullen E., Clayson D.B. The effect of butylated hydroxytoluene on the growth of enzyme-altered foci in male Fischer 344 rat liver tissue. Carcinogenesis. 16:1995;1071-1078.
23. Luster M.I., Germolec D.R., Burleson G.R., Jameson C.W., Ackerman M.F., Lamm K.R., Hayes H.T. Selective immunosuppression in mice of natural killer cell activity by ochratoxin A. Cancer Research. 47:1987;2259-2263.
24. Matsumoto K., Nakamura T. Hepatocyte growth factor: molecular structure and implications for a central role in liver regeneration. Journal of Gastroenterology and Hepatology. 6:1991;509-519.
25. Morrison D. F. (Editor) (1976) Multivariate Statistical Methods, 2nd edn, pp. 415. McGraw-Hill, New York.
26. Nera E.A., Lok E., Iverson F., Ormsby E., Karpinski K.F., Clayson D.B. Short-term pathological and proliferative effects of butylated hydroxyanisole and other phenolic antioxidants in the forestomach of Fischer 344 rats. Toxicology. 32:1984;197-213.
27. Newberne P. M., Nauss K. M. and de Camargo J. L. V. (1983) Lipotopes, immunocompetence, and cancer. Cancer Research (Suppl. 43), 2426s-2434s.
28. Ojcius D.M., Young J.D-E. Cell-mediated killing: Effector mechanisms and mediators. Cancer Cells. 2:1990;138-145.
29. Olsen P., Bille N., Meyer O. Hepatocellular neoplasms in rats induced by butylated hydroxytoluene (BHT). Acta Pharmacology and Toxicology. 53:1983;433-434.
30. Olsen P., Meyer O., Bille N., Wurtzen G. Carcinogenicity study on butylated hydroxytoluene (BHT) in Wistar rats exposed in utero. Food and Chemical Toxicology. 24:1986;1-12.
31. Robinson M.K., Rodrick M.L., Jacobs D.O., Rounds J.D., Collins K.H., Saporoschetz I.B., Mannick J.A., Wilmore D.W. Glutathione depletion in rats impairs T-cell and macrophage immune function. Archives of Surgery. 128:1993;29-35.
32. 2+) mobilization after stimulation with mitogens or anti-CD3 antibodies. Journal of Immunological Methods. 137:1991;237-244.
33. Semple-Roberts E., Hayes M.A., Armstrong D., Becker R.A., Racz W.J., Farber E. Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene. International Journal of Cancer. 40:1987;643-645.
34. Smialowicz R.J., Andrews J.E., Riddle M.M., Rogers R.R., Luebke R.W., Copeland C.B. Evaluation of the immunotoxicity of low level PCB exposure in the rat. Toxicology. 56:1989;197-211.
35. Smith R.T. Cancer and the immune system. Clinical Immunology. 41:1994;831-850.
36. Solt D., Farber E. New principle for analysis of chemical carcinogenesis. Nature. 263:1976;701-793.
37. Steinkamp J.A., Wilson J.S., Saunders G.C., Stewart C.C. Phagocytosis: flow cytometric quantitation with fluorescent microspheres. Science. 215:1982;64-66.
38. Steward C.C., Lehnert B.E., Steinkamp J.A. In vitro and in vivo measurement of phagocytosis by flow cytometry. Methods in Enzymology. 132:1986;183-189.
39. Strome M., Clark J.R., Fried M.P., Rodliff S., Blazar B.A. T-cell subsets and natural killer cell function with squamous cell carcinoma of the head and neck. Archives of Otolaryngology, Head and Neck Surgery. 113:1987;1090-1093.
40. Whiteside T.L., Wang Y.L., Selker R.G., Herberman R.B. In vitro generation and antitumor activity of adherent lymphokine-activated killer cells from the blood of patients with brain tumors. Cancer Research. 48:1988;6069-6075.
41. Witschi H.P. Separation of early diffuse alveolar cell proliferation from enhanced tumor development in mouse lung. Cancer Research. 46:1986;2675-2679.
42. Wolf H.K., Zarnegar R., Michalopoulos G.K. Localisation of hepatocyte growth factor in human and rat tissues: an immunohistochemical study. Hepatology. 14:1991;488-494.
43. Ying T.S, Sarma D.S.R., Farber, E. The sequential analysis of liver cell necrosis. American Journal of Pathology. 99:1980;159-174.