Novel potassium channel activators. II. Synthesis and pharmacological evaluation of 3,4-dihydro-2H-1,4-benzoxazine derivatives: Modification of the aromatic part

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 7, 1999, Pages 971-979

  Matsumoto, Yuzo ^a,b   Tsuzuki, Ryuji ^a   Matsuhisa, Akira ^a   Masuda, Noriyuki ^a   Yamagiwa, Yoko ^a   Yanagisawa, Isao ^a   Shibanuma, Tadao ^a   Nohira, Hiroyuki ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b SAITAMA UNIVERSITY   (Japan)

Author keywords

3,4 dihydro 2H 1,4 benzoxazine; Antihypertensive; Cromakalim; Intracranial pressure; Potassium channel activator

Indexed keywords

2 (7,8 DIHYDRO 6,6 DIMETHYL 6H [1,4]OXAZINO[2,3 F][2,1,3]BENZOXAZIAZOL 8 YL)PYRIDINE 1 OXIDE; 3,4 DIHYDRO 2H 1,4 BENZOXAZINE DERIVATIVE; APRIKALIM; CROMAKALIM; LEMAKALIM; PINACIDIL; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; DOG; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; HEADACHE; HUMAN; INTRACRANIAL PRESSURE; MOLECULAR RECOGNITION; NONHUMAN; ORAL DRUG ADMINISTRATION; PHYSICAL CHEMISTRY; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STRUCTURE ANALYSIS;

EID: 0032791093     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.971     Document Type: Article

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