Influence of the non-competitive NMDA receptor antagonist MK-801 on 2-deoxy-D-glucose-induced hyperphagia in rats

European Journal of Pharmacology

Volumn 378, Issue 2, 1999, Pages 149-152

  Sugimoto, Yumi ^a   Yamada, Jun ^a   Yoshikawa, Tomoko ^a  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

2 Deoxy D glucose; Food intake; MK 801; N(G) nitro L arginine methyl ester; Nitric oxide (NO); NMDA receptor

Indexed keywords

ARGININE; DEOXYGLUCOSE; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYPERPHAGIA; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ARGININE; DEOXYGLUCOSE; DIZOCILPINE MALEATE; DRUG INTERACTIONS; EATING; EXCITATORY AMINO ACID ANTAGONISTS; HYPERPHAGIA; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032790660     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00472-0     Document Type: Article

References (16)

1. Ali S.F., Newport G.D., Holson R.R., Slikker W., Bowyer J.F. Low environmental temperature or pharmacological agents that produce hypothermia decrease methamphetamine neurotoxicity in mice. Brain Res. 658:1994;33-38.
2. Bendnar I., Qian M., Quereshi G.A., Kallstorom L., Johnson A.E., Carrer H., Södersten P. Glutamate inhibits ingestive behaviour. J. Neuroendocrinol. 6:1994;403-408.
3. Bernardis L.L., Bellinger L.L. The lateral hypothalamic area revisited: ingestive behavior. Neurosci. Biobehav. Rev. 20:1996;189-287.
4. Dawson V.L., Dawson T.M., London E.D., Bredt D.S., Snyder S.H. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. U.S.A. 88:1991;6368-6371.
5. Di Monte D.A., Royland J.E., Jakowec M.W., Langston J.W. Role of nitric oxide in methamphetamine neurotoxicity: protection by 7-nitroindazole, an inhibitor of neuronal nitric oxide synthase. J. Neurochem. 67:1996;2443-2450.
6. Itzhak Y. Attenuation of cocaine kindling by 7-nitroindazole, an inhibitor of brain nitric oxide synthase. Neuropharmacology. 35:1996;1065-1073.
7. Montague P.R., Gancayco C.D., Winn M.J., Marchase R.B., Friendlaner M.J. Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortex. Science. 263:1994;973-977.
8. Morley J.E., Flood J.F. Effect of competitive antagonism of NO synthetase on weight and food intake in obese and diabetic mice. Am. J. Physiol. 266:1994;R164-R168.
9. Morley J.E., Kumar V.B., Mattammal M., Villareal D.T. Measurement of nitric oxide synthase and its mRNA in genetically obese (ob/ob) mice. Life Sci. 57:1995;1327-1331.
10. G-nitro-L-arginine, an inhibitor of brain nitric oxidase synthase, in obese Zucker rats. Eur. J. Pharmacol. 230:1993;125-128.
11. Squadrito F., Calapai G., Altavilla D., Cucinotta D., Zingarelli B., Arcoraci V., Campo G.M., Caputi A.P. Food deprivation increases brain nitric oxide synthase and depresses brain serotonin levels in rats. Neuropharmacology. 33:1994;83-86.
12. Stanley B.G., Ha L.H., Spears L.C., Dee M.G. Lateral hypothalamic injections of glutamate, kainic acid, D,L-α-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense transient eating in rats. Brain Res. 613:1993;88-95.
13. Stanley B.G., Willet V.L., Donias H.W., Ha L.H., Spears L.C. The lateral hypothalamus: a primary site mediating excitatory amino acid-elicited eating. Brain Res. 630:1993;41-49.
14. Van den Pol A., Hermans-Borgmeyer I., Honfer M., Ghosh P., Heinemann S. Inotropic glutamate receptor gene expression in the hypothalamus: localization of AMPA, kainate, and NMDA receptor RNA with in situ hybridization. J. Comp. Neurol. 343:1994;428-444.
15. 1A receptor agonist 8-OH-DPAT-induced hyperphagia in rats. Eur. J. Pharmacol. 316:1996;23-26.
16. Yamada J., Sugimoto Y., Yoshikawa T., Horisaka K. Involvement of nitric oxide in 2-deoxy-D-glucose-induced hyperphagia in rats. NeuroReport. 8:1997;2097-2100.