Cytotoxic and genotoxic effects of energetic compounds on bacterial and mammalian cells in vitro

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 444, Issue 1, 1999, Pages 25-39

  Lachance, Bernard ^a   Robidoux, Pierre Yves ^a   Hawari, Jalal ^a   Ampleman, Guy ^b   Thiboutot, Sonia ^b   Sunahara, Geoffrey I ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b DEFENCE RESEARCH AND DEVELOPMENT CANADA VALCARTIER   (Canada)

Author keywords

Explosive; Salmonella typhimurium; TK6 cytotoxicity assay; Trinitrotoluene; V79 mutagenicity assay

Indexed keywords

CYCLONITE; EXPLOSIVE; NITROBENZENE DERIVATIVE; TOLUENE DERIVATIVE; TRINITROTOLUENE;

ANIMAL CELL; ARTICLE; CELL STRAIN V 79; CONTROLLED STUDY; CYTOTOXICITY; GENOTOXICITY; HAMSTER; IN VITRO STUDY; MAMMAL CELL; METABOLITE; MUTAGEN TESTING; MUTAGENIC ACTIVITY; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

ANIMALS; AZOCINES; CELL DEATH; CELL DIVISION; CELL LINE; CRICETINAE; ENVIRONMENTAL POLLUTANTS; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTAGENICITY TESTS; MUTAGENS; RATS; SALMONELLA TYPHIMURIUM; TOLUENE; TRIAZINES; TRINITROBENZENES; TRINITROTOLUENE;

BACTERIA (MICROORGANISMS); CRICETINAE; CRICETULUS GRISEUS; MAMMALIA; SALMONELLA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0032789259     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(99)00073-X     Document Type: Article

References (34)

1. M.G. Ryon, B.C. Pal, S.S. Talmage, R.H. Ross, Database assessment of health and environmental effects of munition production waste products, Final report by Oak Ridge National Laboratory, Contract No. PO83PP3802, Oak Ridge, TN, USA, 1984, AD ORNL-6018.
2. D.H. Rosenblatt, E.P. Burrows, W.R. Mitchell, D.L. Parmer, Organic explosives and related compounds, in: O. Hutzinger (Ed.), The Handbook of Environmental Chemistry, Pt. G, Vol. 3, Springer-Verlag, Berlin, 1991, pp. 195-234.
3. Kolb G., Becker N., Scekller S., Zugmaier G., Pralle H., Wahrendorf J., Haveman K. Increased risk of acute myelogenous leukemia (AML) and chronic myelogenous leukemia (CML) in a county of Hesse (Germany). Soz.-Praventivmed. 38:1993;190-195.
4. Ahlborg G.J., Einisto P., Sorsa M. Mutagenic activity and metabolites in the urine of workers exposed to trinitrotoluene (TNT). Br. J. Ind. Med. 45:1988;353-358.
5. Berthe-Corti L., Jacobi H., Kleihauer S., Witte I. Cytotoxicity and mutagenicity of a 2,4,6-trinitrotoluene (TNT) and hexogen contaminated soil in S. typhimurium and mammalian cells. Chemosphere. 37:1998;209-218.
6. Sunahara G.I., Dodard S., Sarrazin M., Paquet L., Ampleman G., Thiboutot S., Hawari J., Renoux A.Y. Development of a soil extraction procedure for ecotoxicity characterization of energetic compounds. Ecotoxicol. Environ. Saf. 39:1998;185-194.
7. Dodard S.G., Renoux A.Y., Hawari J., Ampleman G., Thiboutot S., Sunahara G.I. Ecotoxicity characterization of dinitrotoluenes and some of their reduced metabolites. Chemosphere. 38:1999;2071-2079.
8. Couch D.B., Abernethy D.J., Allen P.F. The effect of biotransformation of 2,4-dinitrotoluene on its mutagenic potential. Mutagenesis. 2:1987;415-418.
9. Spanggord R.J., Myers C.J., LeValley S.E., Green C.E., Tyson C.A. Structure-activity relationship for the intrinsic hepatotoxicity of dinitrotoluenes. Chem. Res. Toxicol. 3:1990;551-558.
10. Wellington D.R., Mitchell W.R. In vitro cytotoxicity of certain munition nitroaromatic compounds. Chemosphere. 23:1991;363-373.
11. Perchermeier M., Kiefer F., Wiebel F.J. Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines. Toxicol. Lett. 72:1994;53-57.
12. Honeycutt M.E., Jarvis A.S., McFarland V.A. Cytotoxicity and mutagenicity of 2,4,6-trinitrotoluene and its metabolites. Ecotoxicol. Environ. Saf. 35:1996;282-287.
13. Middlebrook T.J., Behnken S.E., Mitchell W.R. Stimulation of microsomal superoxide production in vitro by selected munition compounds. Hazard. Waste Hazard. Mater. 10:1993;347-355.
14. Rajnik S., Mitchell W.R. Effects of 2,4,6-trinitrotoluene and associated munitions on HSP72/73 production in a human lymphoblast cell line. In Vitro Toxicol. 9:1996;183-190.
15. Spanggord R.J., Mortelmans K.E., Griffin A.F., Simmon V.F. Mutagenicity in Salmonella typhimurium and structure-activity relationships of wastewater components emanating from the manufacture of trinitrotoluene. Environ. Mutagen. 4:1982;163-179.
16. Tan E.L., Ho C.H., Griest W.H., Tyndall R.L. Mutagenicity of trinitrotoluene and its metabolites formed during composting. J. Toxicol. Environ. Health. 36:1992;165-175.
17. Styles J.A., Cross M.F. Activity of 2,4,6-trinitrotoluene in an in vitro mammalian gene mutation assay. Cancer Lett. 20:1983;103-108.
18. Won W.D., DiSalvo L.H., Ng J. Toxicity and mutagenicity of 2,4,6-trinitrotoluene and its microbial metabolites. Appl. Environ. Microbiol. 31:1976;576-580.
19. S.A. Hubbard, M.H.L. Green, D. Gatehouse, J.W. Bridges, The fluctuation test in bacteria, in: B.J. Kilbey, M. Legator, W. Nichols, C. Ramel (Eds.), Handbook of Mutagenicity Test Procedures, Elsevier, Amsterdam, 1984, pp. 142-160.
20. Legault R., Blaise C., Rokosh D., Chong-Kit R. Comparative assessment of the SOS chromotest kit and the Mutatox test with the Salmonella plate incorporation (Ames test) and fluctuation tests for screening genotoxic agents. Environ. Toxicol. Water Qual. 9:1994;45-57.
21. Ontario Ministry of Environment, The Fluctuation test, Watershed Management Section, Biohazard Unit, 1991.
22. Borenfreund E., Puerner J.A. A simple quantitative procedure using monolayer cultures for cytotoxicity assays (HTD/NR-90). J. Tissue Cult. Methods. 9:1984;7-9.
23. Cory A.N., Owen T.C., Barltrop J.A., Cory J.G. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun. 3:1991;207-212.
24. D. Jenssen, A quantitative test for mutagenicity in V79 Chinese hamster cells, in: B.J. Kilbey, M. Legator, W. Nichols, C. Ramel (Eds.), Handbook of Mutagenicity Test Procedures, 2nd edn., Elsevier, Amsterdam, 1984, pp. 269-290.
25. McGregor D., Riach C., Brown A., Edwards I., Reynolds D., West K., Willington S. Reactivity of catecholamines and related substances in the mouse lymphoma L5178 cell assay for mutagens. Environ. Mol. Mutagen. 11:1988;523-544.
26. Gilbert R.I. The analysis of fluctuation tests. Mutat. Res. 74:1980;283-289.
27. Aaron C.S., Bolcsfoldi G., Glatt H.R., Moore M., Nishi Y., Stankowski L., Theiss J., Thompson E. Mammalian cell gene mutation assays working group report. Mutat. Res. 312:1994;235-239.
28. Drzyzga O., Gorontzy T., Schmidt A., Blotevogel K.H. Toxicity of explosives and related compounds to the luminescent bacterium Vibrio fischeri NRRL-B-11177. Arch. Environ. Contam. Toxicol. 28:1995;229-235.
29. Karamova N.S., Il'inskaya O.N., Ivanchenko O.B. Mutagenic activity of 2,4,6-trinitrotoluene: the role of metabolizing enzymes. Russ. J. Genet. 30:1994;785-788.
30. B. Lachance, J. Hawari, N. Sharmeen, S. Dodard, P.Y. Robidoux, G. Ampleman, S. Thiboutot, G. Sunahara, Cytotoxic and genotoxic effects of some energetic compounds tested using various bacterial and mammalian cell assays, SETAC 17th Annual Meeting, Abstract book, 17-21 November 1996, Washington, DC, SETAC Press, Pensacola, FL, USA.
31. Karamova N.S., Mynina I.I., Garaeva G.G., Ivanchenko O.B., Il'inskaya O.N. Compounds 2,4,6-trinitrotoluene and 2,4-diamino-6-nitrotoluene: the absence of recA-dependent mutagenesis. Russ. J. Genet. 31:1995;528-531.
32. Reddy G., Reddy T.V., Choudhury H., Daniel F.B., Leach G.J. Assessment of environmental hazards of 1,3,5-trinitrobenzene. J. Toxicol. Environ. Health. 52:1997;447-460.
33. L. Gordon, W.R. Hartley, 2,4,6-Trinitrotoluene, in: W.C. Roberts et al. (Eds.), Drinking Water Health Advisory: Munitions, Lewis Publishers, Boca Raton, FL, 1992, pp. 327-398.
34. Anonymous, RDX, Dangerous Properties of Industrial Materials Report 12, 1992, pp. 248-256.