Synthesis and evaluation of β-homocysteine derivatives of 99mTc-L,L-EC and 99mTc-L,L-ECD

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 42, Issue 7, 1999, Pages 683-699

  Mang'era, K O ^a   Verbruggen, A ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Bifunctional chelating agents; Homocysteine; L,L EC; L,L ECD; Technetium

Indexed keywords

ALKALINITY; CHELATION; ETHYLENE; ETHYLENEDIAMINETETRAACETIC ACID; MAMMALS; TECHNETIUM;

ALKALINE PH; BIFUNCTIONAL CHELATING AGENT; BRAIN UPTAKE; CARBOXYL GROUPS; HOMOCYSTEINES; L,L-(EC) AND ITS DIETHYLESTER; L,L-EC; PROPERTY; STABLE COMPLEXES; TECHNETIUM-;

ELECTROPHORESIS;

CARBOXYL GROUP; ETHYLENE DERIVATIVE; HOMOCYSTEINE; NITROGEN; SULFUR; TECHNETIUM 99M; THIOL DERIVATIVE;

ARTICLE; COMPLEX FORMATION; DRUG SYNTHESIS; ISOTOPE LABELING; LIGAND BINDING; STEREOSPECIFICITY; TEMPERATURE;

EID: 0032788905     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(199907)42:7<683::AID-JLCR230>3.0.CO;2-0     Document Type: Article

References (19)

1. Verbruggen A., Nosco D., Van Nerom C., Bormans G., Adriaens P. and De Roo M. - J. Nucl. Med. 33: 551 (1992)
2. Léveillé J., Demonceau G., De Roo M., Rigo P., Taillefer R., Morgan R.A., Kupranick D. and Walovitch R.C. - J. Nucl. Med. 30: 1902 (1989)
3. Baidoo K.E., Lever S.Z. and Scheffel U. - Bioconjug. Chem. 5: 114 (1994)
4. Verbruggen A. - In: Current Directions in Radiopharmaceutical Development, Mather S.J. Ed., Kluwer Academic Publications, Dordrecht, 1996, p 31-46.
5. Del Rosario R.B., Yung J-W., Baidoo K.E., Lever S.Z., and Wieland D.M. -Nucl. Med. Biol. 21: 197 (1994)
6. Eisenhut M., Lehmann W.D., Becker W., Behr T., Elser H., Strittmatter-W; Steinstrasser A., Baum R.P., Valerius T., Repp R., and Deo Y. - J. Nucl. Med. 37: 362 (1996)
7. Samnick S., Brandau W., Sciuk J., Steinsträsser A., and Schober O. Nucl. Med. Biol. 22: 573 (1995)
8. DiZio J.P., Anderson C.J., Davison A., Ehrhardt G.J., Carlson K. E., Welch M.J. and Katzenellenbogen J.A. - J. Nucl. Med. 33: 558 (1992)
9. Balenović K. and Fleš D. - J. Org. Chem. 17: 347 (1952)
10. Gordon E.M., Godfrey J.D., Delaney N.G., Asaad M.M., Von Langen D. and Cushman D.W. - J. Med. Chem. 31: 2199 (1988)
11. Jefford C.W., Tang Q. and Zaslona A. - J. Am. Chem. Soc. 113: 3513 (1991)
12. Greenstein J.P. and Winitz M. - Chemistry of the Amino Acids, volume 2, Robert E. Krieger Publishing Company, Malabar, 1984.
13. Yonemitsu O., Hamada T. and Kanaoka Y. - Tetrahedron Lett. 23: 1819 (1969)
14. Edwards D.S., Cheesman E.H., Watson M.W., Watson M.W., Maheu L.J., Nguyen S.A., Dimitre L., Nason T., Watson A.D. and Walovitch R. - In: Technetium and Rhenium in Chemistry and Nuclear Medicine 3; Nicolini M., Bandoli G., Mazzi U, Eds., Cortina International, Verona, 1990, p 433-444.
15. Marzilli L.G., Banaszczyk M.G., Hansen L., Kuklenyik Z., Cini R. and Taylor A. - Inorg. Chem. 33: 4850 (1994)
16. Taylor A., Hansen L., Eshima D., Malveaux E., Folks R., Shattuck L., Lipowska M. and Marzilli L.G. - J. Nucl. Med. 38: 821 (1997)
17. Blondeau P., Berse C. and Gracel D. - Can. J. Chem. 45: 49 (1967)
18. Walovitch R.C., Hill T.C., Garrity S.T., Cheesman E.H., Burgess B.A., O'Leary D.A., Watson A.D., Ganey M.V., Morgan R.A. and Williams S.J. - J. Nucl. Med. 30: 1892 (1989)
19. Hudlicky M. - J. Org. Chem. 45: 5377 (1980)