Effects of restraint stress and spontaneous hypertension on neuropeptide Y neurones in the brainstem and arcuate nucleus

Journal of Neuroendocrinology

Volumn 11, Issue 9, 1999, Pages 715-723

  Krukoff, T L ^a   MacTavish, D ^a   Jhamandas, J H ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Arcuate nucleus; c fos; Neuropeptide Y; Nucleus of the tractus solitarii; Spontaneous hypertension; Stress; Ventrolateral medula

Indexed keywords

MESSENGER RNA; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARCUATE NUCLEUS; ARTICLE; AUTONOMIC NERVE; BRAIN STEM; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; GENE EXPRESSION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION STRESS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MEDULLA OBLONGATA; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SOLITARY TRACT NUCLEUS;

ANIMALS; ARCUATE NUCLEUS; BRAIN STEM; HYPERTENSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NEURONS; NEUROPEPTIDE Y; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, SPRAGUE-DAWLEY; RESTRAINT, PHYSICAL; STRESS;

EID: 0032788858     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.1999.00391.x     Document Type: Article

References (43)

1. Bai FL, Yamano M, Shiotani Y, Emson PC, Smith AD, Powell JF, Tohyama M. An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat. Brain Res 1985; 331: 172-175.
2. Schwanzel-Fukuda M, Morrell JI, Pfaff DW. Localization of forebrain neurons which project directly to the medulla and spinal cord of the rat by retrograde tracing with wheat germ agglutinin. J Comp Neurol 1984; 226: 1-20.
3. Chronwall BM, DiMaggio DA, Massari VJ, Pickel VM, Ruggiero DA, O'Donohue TL. The anatomy of neuropeptide Y-containing neurons in rat brain. Neuroscience 1985; 15: 1159-1181.
4. De Quidt ME, Emson PC. Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system. II. Immunohistochemical analysis. Neuroscience 1986; 18: 545-618.
5. Everitt BJ, Hökfelt T, Terenius K, Tatemoto K, Mutt V, Goldstein M. Differential coexistence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat. Neuroscience 1984; 11: 443-462.
6. Edwards GL, Cunningham JT, Beltz TG, Johnson AK. Neuropeptide Y-immunoreactive cells in the caudal medulla project to the median preoptic nucleus. Neurosci Lett 1989; 105: 19-26.
7. Krukoff TL, Vu T, Harris KH, Aippersbach S, Jhamandas JH. Neurons in the rat medulla oblongata containing neuropeptide Y-, angiotensin II-, or galanin-like immunoreactivity project to the parabrachial nucleus. Neuroscience 1992; 47: 175-184.
8. Sawchenko PE, Swanson LW, Grzanna R, Howe PRC, Bloom SR, Polak JM. Colocalization of neuropeptide Y immunoreactivity in brain-stem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus. J Comp Neurol 1985; 241: 138-153.
9. Gray TS, Morley JE, Neuropeptide Y. anatomical distribution and possible function in mammalian nervous system. Life Sci 1986; 38: 389-401.
10. Billington CJ, Briggs JE, Harker S, Grace M, Levine AS. Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism. Am J Physiol 1994; 266: R1765-R1770.
11. Leibowitz SF, Sladek C, Spencer L, Tempel D. Neuropeptide Y, epinephrine and norepinephrine in the paraventricular nucleus: stimulation of feeding and the release of corticosterone, vasopressin and glucose. Brain Res Bull 1988; 21: 905-912.
12. Morrir BJ. Neuronal localisation of neuropeptide Y gene expression in ral brain. J Comp Neurol 1989; 290: 358-368.
13. Haas DA, George SR. Neuropeptide Y administration acutely increases hypothalamic corticotropin-releasing factor immunoreactivity: lack of effect in other rat brain regions. Life Sci 1987; 41: 2725-2731.
14. Wahlestedt C, Skagerberg G, Ekman R, Heilig M, Sundler F, Håkanson R. Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat. Brain Res 1987; 417: 33-38.
15. McLean KJ, Jarrott B, Lawrence AJ. Neuropeptide Y gene expression and receptor autoradiography in hypertensive and normotensive rat brain. Molec Brain Res 1996; 35: 249-259.
16. Krukoff TL, MacTavish D, Jhamandas JH. Changes in blood, and pressure induce c-fos expression in brainstem neurons that project to the paraventricular nucleus of the hypothalamus. Mol Brain Res 1995; 34: 99-108.
17. Krukoff TL, Khalili P. Stress-activation of nitric oxide-producing neurons in the rat brain. J Comp Neurol 1997; 377: 509-519.
18. Larhammar D, Ericsson A, Persson H. Structure and expression of the rat neuropeptide Y gene. PNAS 1987; 84: 2068-2072.
19. Krukoff TL, MacTavish D, Jhamandas JH. Hypertensive rats exhibit heightened expression of corticotropin-releasing factor in activated central neurons in response to restraint stress. Mol Brain Res 1999; 65: 70-79.
20. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. Sydney: Academic Press, 1986.
21. Johnson ML, Ely DL, Turner ME. Genetic divergence between the Wistar-Kyoto rat and the spontaneously hypertensive rat. Hypertension 1992; 19: 425-427.
22. St. Lezin E, Simonet L, Pravenee M, Krutz TW. Hypertensive strains and normotensive 'control' strains. Hypertension 1992; 19: 419-424.
23. Riche D, De Pommery J, Menetrey D. Neuropeptides and catecholamines in efferent projections of the nuclei of the solitary tract in the rat. J Comp Neurol 1990; 293: 399-424.
24. Ceccatelli S, Vilar MJ, Goldstein G, Hökfelt T. Expression of c-fos immunoreactivity in transmitter-characterized neurons after stress. PNAS 1989; 86: 9569-9573.
25. Pezzone MA, Lee W-S, Hoffman GE, Pezzone KM, Rabin BS. Activation of brainstem catecholaminergic neurons by conditioned and unconditioned aversive stimuli as revealed by c-fos immunoreactivity. Brain Res 1993; 608: 310-318.
26. Fuxe K, Agnati LF, Härfstrand A, Zini I, Tatemoto K, Pich EM, Hökfelt T, Mutt V, Terenius L. Central administration of neuropeptide Y induces hypotension, bradypnea and EEG synchronization in the rat. Acta Physiol Scand 1983; 118: 189-192.
27. Härfstrand A. Intraventricular administration of neuropeptide Y (NPY) induces hypotension, bradycardia and bradypnoea in the awake unrestrained male rat. Counteraction by NPY-induced feeding behaviour. Acta Physiol Scand 1986; 128: 121-123.
28. Aguirre JA, Fuxe K, Agnati LF, von Euler G. Centrally injected neuropeptide Y(13-16) produces vasopressor effects and antagonizes the vasodepressor action of neuropeptide Y(1-36) in the awake male rat. Neurosci Lett 1990; 118: 5-8.
29. Grundemar L, Wahlestedt C, Reis DJ Long-lasting inhibition of the cardiovascular responses to glutamate and the baroreceptor reflex elicited by neuropeptide Y injected into the nucleus tractus solitarius of the rat. Neurosci Lett 1991; 122: 135-139.
30. Tseng C-J, Mosqueada-Garcia R, Appelsamy M, Robertson D. Cardiovascular effects of neuropeptide Y in rat brainstem nuclei. Circ Res 1988; 64: 55-61.
31. Westfall TC, Martin J, Chen X, Ciarleglio A, Carpentier S, Henderson K, Kneupfer M, Beinfeld M, Naes L. Cardiovascular effects and modulation of noradrenergic neurotransmission following central and peripheral administration of neuropeptide Y. Synapse 1988; 2: 299-307.
32. Liu JP, Clarke IJ, Funder JW, Engler D. Studies on the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation: potential involvement in the pseudo-Cushing's syndrome of endogenous depression and anorexia nervosa. J Clin Invest 1994; 93: 1439-1450.
33. Everitt BJ, Meister B, Hökfelt T, Melander T, Terenius L, Rökaeus Å, Theordorsson-Norheim E, Dockray G, Edwardson J, Cuello C, Elde R, Goldstein M, Hemmings H, Ouimet C, Walaas I, Greengard P, Vale W, Weber E, Wu J-Y, Chang K-J. The hypothalamic arcuate nucleus-median eminence complex: immunohistochemistry of transmitters, peptides and DARPP-32 with special reference to coexistence in dopamine neurons. Brain Res Rev 1986; 11: 97-155.
34. Rivet JM, Castagne V, Corder R, Gaillard R, Mormede P. Study of the influence of stress and adrenalectomy on central and peripheral neuropeptide Y levels. Comparison with catecholamines. Neuroendocrinology 1989; 50: 413-420.
35. Pralong FP, Corder R, Gaillard RC. The effects of chronic glucocorticoid excess, adrenalectomy and stress on neuropeptide Y in individual rat hypothalamic nuclei. Neuropeptides 1993; 25: 223-231.
36. Corder CR, Castagne V, Rivet JM, Mormede P, Gaillard RC. Central and peripheral effects of repeated stress and high NaCl diet on neuropeptide Y. Physiol Behav 1992; 52: 205-210.
37. Cintra A, Fuxe K, Solfrini V, Agnati LF, Tinner B, Wikstrom AC, Staines W, Okret S, Gustafsson JA. Central peptidergic neurons as targets for glucocorticoid action. Evidence for the presence of glucocorticoid receptor immunoreactivity in various types of classes of peptidergic neurons. J Steroid Biochem Molec Biol 1991; 40: 93-103.
38. Härfstrand A, Cintra A, Fuxe K, Aronsson M, Wikstrom AC, Okret S, Gustafsson JA, Agnati LF. Regional differences in glucocorticoid receptor immunoreactivity among neuropeptide Y immunoreactive neurons of the rat brain. Acta Physiol Scand 1989; 135: 3-9.
39. Akabayashi A, Watanabe Y, Wahlestedt C, McEwan BS, Paez X, Leibowitz SF. Hypothalamic neuropeptide Y, its gene expression and receptor activity: relation to circulating corticosterone in adrenalectomized rats. Brain Res 1994; 665: 201-212.
40. Schwartz MW, Marks JL, Sipols AJ, Baskin DG, Woods SC, Kahn SE, Porte D. Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats. Endocrinology 1994; 128: 2645-2647.
41. Dallman MF, Akana SF, Strack AM, Hanson ES, Sebastian RJ. The neural network that regulates energy balance is responsive to glucocorticoids and insulin and also regulates HPA axis responsivity at a site proximal to CRF neurons. Ann NY Acad Sci 1995; 771: 730-742.
42. Clark JT, Sahu A, Mrotek JJ, Kalra SP. Sexual function and neuropeptide Y levels in selected brain regions in male spontaneously hypertensive rats. Am J Physiol 1991; 261: R1234-R1241.
43. Pavia JM, Morris MJ. Age-related changes in neuropeptide Y content in brain and peripheral tissues of spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 1994; 21: 335-338.