Characterization of a polyclonal antibody raised against the human melanocortin-1 receptor

Annals of the New York Academy of Sciences

Volumn 885, Issue , 1999, Pages 372-382

  Böhm, Markus ^a   Brzoska, Thomas ^a   Schulte, Ursula ^a   Schiller, Meinhard ^a   Kubitscheck, Ulrich ^a   Luger, Thomas A ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; MELANOCORTIN RECEPTOR; POLYCLONAL ANTIBODY; SYNTHETIC PEPTIDE;

AMINO TERMINAL SEQUENCE; ANTIBODY AFFINITY; ANTIGENICITY; CONFERENCE PAPER; DOT HYBRIDIZATION; FLUORESCENCE ACTIVATED CELL SORTER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPEROXIDASE STAINING; MELANOCYTE; MELANOMA CELL; SKIN;

EID: 0032787657     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb08693.x     Document Type: Conference Paper

References (22)

1. 1. Mountjoy, K.G. et al. 1992. The cloning of a family of genes that encode the melanocortin receptors. Science 257: 1247-1251.
2. 2. Cone, R.D. et al. 1996. The melanocortin receptors: agonists, antagonists and the hormonal control of pigmentation. Rec. Prog. Horm. Res. 51: 287-318.
3. 3. Hartmeyer, M. et al. 1997. Human microvascular endothelial cells (HMEC-1) express the melanocortin receptor type 1 and produce increased levels of IL-8 upon stimulation with α-MSH. J. Immunol. 159: 1930-1937.
4. 4. Brzoska, T. et al. 1997. UVB irradiation regulates the expression of proopiomelanocortin, prohormone convertase 1 and melanocortin receptor 1 by human keratinocytes. (Abstract). J. Invest. Dermatol. 108: 622.
5. 5. Böhm, M. et al. 1997. Human fibroblasts express melanocortin-1 receptors and respond to alpha-melanocyte stimulating hormone with increased secretion of interleukin-6 and interleukin-8. (Abstract). J. Invest. Dermatol. 108: 593.
6. 6. Bhardwaj, R. et al. 1997. Evidence for the differential expression of the functional α-melanocyte-stimulating hormone receptor MC-1 on human monocytes. J. Immunol. 158: 3378-3384.
7. 7. Star, R.A. et al. 1995. Evidence of autocrine modulation of macrophage nitric oxide synthase by α-melanocyte-stimulating hormone. Proc. Natl. Acad. Sci. USA 92: 8016-8020.
8. 8. Böhm, M. et al. Alpha-melanocyte-stimulating hormone modulates the activation of NF-κB and AP-1 and the secretion of interleukin-8 in human dermal fibroblasts. Ann. N.Y. Acad. Sci. 885: this volume.
9. 9. Kalden, D.-H. et al. α-MSH modulates LPS-induced adhesion molecules. Ann. N.Y. Acad. Sci. 885: this volume.
10. 10. Brzoska, T. et al. Molecular basis of the α-MSH/IL-1 antagonism. Ann. N.Y. Acad. Sci. 885: this volume.
11. 11. Kiss, M. et al. 1995. α-Melanocyte stimulating hormone induces collagenase/metallomatrix proteinase-1 in human dermal fibroblasts. Biol. Chem. Hoppe-Seyler 376: 425-430.
12. 12. Simon, M.M. et al. 1994. POMC-derived peptide hormones alpha-MSH and ACTH affect proliferation and differentiation of cultured human keratinocytes. J. Invest. Dermatol. 103: 419-425.
13. 13. Orel, L. et al. 1997. α-Melanocyte-stimulating hormone downregulates differentiation/driven heat shock protein 70 expression in keratinocytes. J. Invest. Dermatol. 108: 401-408.
14. 1 receptors to malignant melanoma cells. Eur. J. Pharmacol. 288: 277-283.
15. 15. Thörnwall, M. et al. 1996. Immunohistochemical detection of the melanocortin 1 receptor in human testis, ovary and placenta using specific monoclonal antibodies. Horm. Res. 48: 215-218.
16. 16. Herlyn, M. et al. 1989. Growth regulatory factors for normal, premalignant, and malignant human melanoma cells in vitro. Adv. Cancer Res. 54: 213-220.
17. 17. Chhaljani, V. et al. 1992. Molecular cloning and expression of the human melanocyte-stimulating hormone receptor cDNA. FEBS Lett. 309: 417-420.
18. 18. Donatien, P.D. et al. 1992. The expression of functional MSH receptors on cultured human melanocytes. Arch. Dermatol. Res. 284: 424-426.
19. 19. Xia, Y. et al. 1996. Immunological localization of melanocortin 1 receptor on the cell surface of WM266-4 human melanoma cells. Cancer Lett. 98: 157-163.
20. 20. Orlow, S.J. et al. 1990. Internal binding sites for MSH: analysis in wild-type and variant Cloudman melanoma cells. 142: 129-136.
21. 21. Böhm, M. et al. 1998. The pilosebaceous unit is part of the skin immune system. Dermatology 196: 75-79.
22. 22. Nanninga, P.B. et al. 1991. Evidence for alpha-MSH binding sites on human scalp hair follicles: preliminary results. Pigm. Cell Res. 4: 193-198.