Effects of bupivacaine on human erythrocytes submitted to stress and evidence for an interaction between bupivacaine and flumazenil

British Journal of Clinical Pharmacology

Volumn 48, Issue 6, 1999, Pages 826-828

  Lenfant, François ^a,b   Lahet, Jean Jacques ^a   Volot, François ^c   Schafer, Isabelle ^a   Freysz, Marc ^c   Rochette, Luc ^a  

^a UNIVERSITÉ DE BOURGOGNE   (France)

^b HÔPITAL DU BOCAGE   (France)

^c NONE

Author keywords

Bupivacaine; Drug interaction; Erythrocytes; Flumazenil; Oxidative stress

Indexed keywords

BUPIVACAINE; FLUMAZENIL; POTASSIUM;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ERYTHROCYTE; FLAME PHOTOMETRY; HUMAN; HUMAN CELL; NORMAL HUMAN; OXIDATIVE STRESS; POTASSIUM TRANSPORT; PRIORITY JOURNAL;

ANESTHETICS, LOCAL; ANTIDOTES; BUPIVACAINE; DRUG INTERACTIONS; ERYTHROCYTES; FLUMAZENIL; HUMANS; OXIDATIVE STRESS; POTASSIUM;

EID: 0032786870     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1999.00083.x     Document Type: Article

References (11)

1. 1 Lenfant F, Volot F, Freysz M, Wilkening M. Le flumazénil corrige-t-il les troubles de la conduction intracardiaque induits par l'injection intraveineuse accidentelle de bupivacaïne? Ann Fr Anesth Reanin 1996 15: 1196-1198.
2. 2 Bruguerolle B, Emperaire N. Local anesthetic-induced toxicity may be modified by low doses of flumazenil. Life Sci 1992 51: 1-4.
3. 3 Freysz M, Béal JL, Timour Q, Bertrix L, Faucon G. Toxicité systémique des anesthésiques locaux. Facteurs pharmacocinétiques et pharmacodynamiques. Ann Fr Anesth Reanin 1988 7: 181-188.
4. 4 Sztark F, Malgat M, Dahadie P, Mazat JP. Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bionergetics. Anesthesiology 1998 88: 1340-1349.
5. 5 Fehri B, Advenier C. The relexant effect of diazepam on rat tracheal strips. J Pharm Belg 1997 52: 117-122.
6. 6 Brogden RN, Goa KL. Flumazenil: a preliminary review of its benziodiazepine antagonist properties, intrinsic activity and therapeutic use. Drugs 1992 35: 448-467.
7. 7 Sandu I, Ware K, Grisham M. Peroxyl radical-mediated hemolysis role of lipid, protein and sulfhydryl oxidation. Free Radio Res Commun 1994 16: 111-122.
8. 8 Caramelo C, Riesco A, Outeirino J, et al. Effects of nitric oxide on red blood cells: Changes in erythrocytes resistance to hypotonic hemolysis and potassium efflux by experimental maneuvers that decrease nitric oxide. Biochem Biophys Res Commun 1994 199: 447-454.
9. 9 Seeman P. The membrane actions of anesthetics and tranquilizers. Pharmacol Rev 1972 24: 583-655.
10. 10 Kang MY, Tsuchiya M, Packer L, Manabe M. In vitro study on antioxidant potential of various drugs used in the perioperative period. Acta Anaesthesiol Scand 1998 42: 4-12.
11. 11 Bruguerolle B, Lorec AM. Lack of bupivacaine kinetic changes induced by flumazenil in mice. Life Sci 1993 52: 165-167.