Normohomocysteinaemia and vitamin-treated hyperhomocysteinaemia are associated with similar risks of cardiovascular events in patients with premature peripheral arterial occlusive disease. A prospective cohort study

Journal of Internal Medicine

Volumn 246, Issue 1, 1999, Pages 87-96

  De Jong, S C ^a,b   Stehouwer, C D A ^a,b   Van Den Berg, M ^a,b   Geurts, T W ^b   Bouter, L M ^a   Rauwerda, J A ^a,c  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Cardiovascular events; Mild hyperhomocysteinaemia; Peripheral arterial occlusive disease; Prospective study; Vitamin treatment

Indexed keywords

FOLIC ACID; HOMOCYSTEINE; METHIONINE; PYRIDOXINE; VITAMIN;

ADULT; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CONTROLLED STUDY; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; PROSPECTIVE STUDY;

EID: 0032786509     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.1999.00541.x     Document Type: Article

References (27)

1. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I, Hyperhomocysteinemia; an independent risk factor for vascular disease. N Engl J Med 1991; 324: 1149-55.
2. Graham IM, Daly LE, Refsum HM, Robinson K, Brattström LE, Ueland PM, et al. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA 1997; 277: 1775-81.
3. Stampfer MJ, Malinow MR, Willett WC, Newcomer LM, Upson B, Ullman D, et al. A prospective study of plasma homocyst(e)ine and risk or myocardial infarction in US physicians. JAMA 1992; 268: 877-81.
4. Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Schaper AG. Prospective study of serum total homocysteine concentration and risk or stroke in middle-aged British men. Lancet 1995; 346: 1393-8.
5. Fermo I, D'Angelo SV, Paroni R, Mazzola G, Calori G, D'Angelo A. Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease. Ann Intern Med 1995; 123: 747-53.
6. Ueland PM, Refsum H, Brattström L. Plasma homocysteine and cardiovascular disease. In: Francis RB Jr. ed. Atherosclerotic Cardiovascular Disease. Hemostasis and Endothelial Function New York: Marcel Dekker, 1992; 183-236.
7. Van den Berg M, Franken DG, Boers GHJ, Blom HJ, Jakobs C, Stehouwer CDA, Rauwerda JA. Combined vitamin B6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia. J Vasc Surg 1994; 20: 933-40.
8. Franken DG, Boers GHJ, Blom HJ, Trijbels FJM, Kloppenburg PWC. Treatment of mild hypehomocysteinemia in vascular patients. Arterioscler Thromb Vasc Biol 1994; 14: 465-70.
9. van den Berg M, Boers GHJ. Homocystinuria: what about mild hyperhomocysteinaemia? Postgrad Med J 1996; 72: 513-8.
10. Van den Berg M, Stchouwer CDA, Bierdrager E, Rauwerda JA. Plasma homocysteine and severity of atherosclerosis in young patients with lower-limb atherosclerosis disease. Arterioscler Thromb Vasc Biol 1996; 16: 165-71.
11. Ubbink JB, Vermaak WJH, Bennett JM, Becker PJ, van Staden DA, Bissbort S. The prevalence of homocysteinemia and hypercholesterolemia in angiographically defined coronary heart disease. Klin Wochenschr 1991; 69: 527-34.
12. Selhub S, Jacques PF, Bostom AG, D'Agostino RB, Wilson PWF, Belanger AJ, et al. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med 1995; 332: 286-91.
13. Mudd SH, Levy HL, Skovby F. Disorders of transsulfulration. In: Scriver CR, Beaud, Sly WS, Valle D, eds. The Metabolic and Molecular Basis of Inherited Disease. New York: McGraw-Hill, 1995; 1279-327.
14. Van den Berg M, Boers GHJ, Franken DG, Blom HJ, van Kamp GJ, Jakobs C, et al. Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease. Eur J Clin Invest 1995; 25: 176-81.
15. Criqui MH, Langer RD, Fronek A, Feigelson HS, Klauber MR, McCann TJ, Browner D. Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med 1992; 326: 381-6.
16. Leng GL, Lee AJ, Fowkes FGR, Whiteman M, Dunbar J, Housley E, Ruckley CV. Incidence, natural history and cardiovascular events in symptomatic and asymptomatic peripheral arterial disease in the general population. Int J Epid 1996; 25: 1172-81.
17. Taylor LM, DePrang RD, Harris EJ, Porter JM. The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease. J Vasc Surg 1991; 13: 128-36.
18. Nygård O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997; 337: 230-6.
19. Te Poele-Pothof MTWB, van den Berg M, Fanken DG, Boers GHJ, Jakobs C, de Kroon IFI, et al. Three different methods for the determination of total homocysteine in plasma. Ann Clin Biochem 1995; 32: 218-20.
20. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
21. Harris LM, Peer R, Curl R, Pillai L, Upson J, Ricotta JJ. Long-term follow-up of patients with early atherosclerosis. J Vasc Surg 1996; 23: 576-81.
22. Levy PJ, Hornung CA, Haynes JL, Rush DS. Lower extremity ischemia in adults younger than forty years of age: a community-wide survey of premature atherosclerotic arterial disease. J Vasc Surg 1994; 19: 873-81.
23. O'Riodain DS, O'Donnell M. Realistic expectations for the patient with intermittent claudication. Br J Surg 1991; 78: 861-3.
24. Wilcken DEL, Wilcken B. The natural history of vascular disease in homocystinuria and the effects of treatment. J Inher Metab Dis 1997; 20: 295-300.
25. Kuller LH, Evans RW. Homocysteine, vitamins and cardiovascular disease. Circulation 1998; 98: 196-9.
26. Rimm EB, Willett WC, Hu FB, Sampson L, Colditz GA, Manson JE, Hennekens C, Stampfer MJ. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA 1998; 279: 359-64.
27. Folsom AR, Nieto FJ, McGovern PG, Tsai MY, Malinow MR, Eckfeldt JH, Hess DL, Davis CE. Prospecitve study of coronary heart disease incidence in relation to fasting total homcysteine, related genetic polymorphisms, and B vitamins. The atherosclerosis risk in communities (ARIC) Study. Circulation 1998; 98: 204-10.