Suppression of the TPA-induced expression of nuclear-protooncogenes in mouse epidermis by crocetin via antioxidant activity

Anticancer Research

Volumn 19, Issue 5 B, 1999, Pages 4221-4227

  Hsu, Jeng Dong ^a   Chou, Fen P I ^a   Lee, Miao Jane ^a   Chiang, Huei Ching ^a   Lin, Yu Ling ^a   Shiow, Song Jui ^a   Wang, Chau Jong ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Antioxidation; c Fos; c Jun; c Myc; Crocetin; Skin carcinogenesis

Indexed keywords

ANTIOXIDANT; CROCETIN; HYDROGEN PEROXIDE; MYELOPEROXIDASE; ONCOPROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DERMIS; EPIDERMIS; EPIDERMIS HYPERPLASIA; FEMALE; GENE EXPRESSION REGULATION; IMMUNOCYTOCHEMISTRY; MOUSE; MUSCLE; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTO ONCOGENE; SKIN CARCINOGENESIS; TOPICAL DRUG ADMINISTRATION; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; CAROTENOIDS; CELL NUCLEUS; EPIDERMIS; FEMALE; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; MICE; PEROXIDASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; TETRADECANOYLPHORBOL ACETATE;

EID: 0032786481     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Wattenberg LW: Inhibition of chemical carcinogens. Adv Cancer Res 26: 197-226, 1978.
2. Ames BN: Dietary carcinogens and anticarcinogens. Science 221: 1256-1264, 1983.
3. Lin JK and Wang CJ: Protection of crocin dyes on the acute hepatic damage induced by aflatoxin B, and dimethylnitrosamine in rats. Carcinogenesis 7: 595-599, 1986.
4. Wang CJ, Chou MY and Lin JK: Inhibition of growth and development of the transplantable C-6 glioma cells inoculated in rats by retinoids and carotenoids. Cancer Lett 46: 135-142, 1989
5. Wang CJ, Shiah HS and Lin JK: Modulatory effect of crocetin on aflatoxin B cytotoxicity and DNA adduct formation in C3H10T1/2 fibroblast cells. Cancer Lett 56: 1-10, 1991.
6. Wang CJ and Lin JK: Effect of crocetin on the hepatotoxicity and hepatic DNA- binding of aflatoxin B, in the rat. Carcinogenesis 12: 459-462, 1991.
7. Wang CJ, Hsu JD and Lin JK: Suppression of aflatoxin B1-induced hepatotoxic lesions by crocetin (a natural carotenoid). Carcinogenesis 12: 1807-1810, 1991.
8. Wang CJ, Lee MJ, Chang MC and Lin JK: Inhibition of tumor promotion in benzo(a)pyrene-initiated CD-1 mouse skin by crocetin: Carcinogenesis 16: 187-191, 1995.
9. Chang WC, Lin YL, Lee MJ, Shiow SJ and Wang CJ: Inhibitory effe,ct of crocetin on benzo(a)pyrene genotoxicity and neoplastic transformation in C3H1OT1/2 cells. Anticancer Res 16: 3603-3608, 1996.
10. Wang CJ, Cheng TC, Liu JY, Chou FP, Kuo ML and Lin JK: Inhibitions of protein kinase C and proto-oncogene expressions in NIH3T3 cells by crocetin. Mol Carcinogenesis 17: 235-240, 1996.
11. Gainer JC, Wallis DA and Jones JR: The effect of crocetin on skin papillomas and Rous sarcoma. Oncology 33: 222-226, 1976.
12. Wang CJ, Hwang LS and Lin JK: Reversible hepatic black pigmentation and enzyme alteration induced by prolonged feeding of high dose of crocin dyes in rats. Proc Ntal Sci Council ROC B 8: 246-253 1984.
13. Bernstein LR and Colburn NH: AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells. Science 244: 566-569, 1989.
14. Dong Z, Birrer MJ, Watts RG, Matrisian LM and Colburn NH: Blocking of tumor promoter induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. Proc Natl Acad Sci 91: 609-613, 1994.
15. Sakai M, Okuda A and Hatayama I: Structure and expression of the rat cjun messenger RNA: tissue distribution and increase during chemical hepatocarcinogenesis. Cancer Res 49: 5633-5637,1989.
16. Frain M, Swart G and Monaci P: The liver-specific transcription factor LF-B1 contains a highly diverged homobox DNA binding domain. Cell 59: 145-147,1989.
17. Cooper GM: Oncogenes in mitogenic signal transduction pathway. In: Oncogenes (Cooper GM, ed). Boston, Jones and Bartlettt Publishers, 1990, pp 255-276.
18. Pick E and Keisari Y: A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J Immunol Methods 38: 161-170, 1980.
19. Wei H, Tye L, Bresnick E and Brit DF: Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Res 50: 499-502,1990.
20. Huachen W and Krystyna F: Suppression of tumor promoter-induced oxidative events and DNA damage in vivo by Sarcophytol A: a possible mechanism of antipromotion. Cancer Res 52: 2298-2303, 1992.
21. Hashimoto Y, Tajima O, Hashiba H, Nose K and Kuroki T: Erevated expression of secondary, but not early, responding genes to phorbol ester tumor promoters in papillomas and carcinomas of mouse skin. Mol Carcinogenesis 3: 302-308, 1990.
22. O'Brien TG: The induction of ornithine decarboxylase as an early, possibly obligatory, event in mouse skin carcinogenesis. Cancer Res 36: 2644-2653, 1976.
23. Blumberg PM: Protein kinase C as the receptor for the phorbol ester tumor promoters: Sixth Rhoads Memorial Award Lecture. Cancer Res 48: 1-8, 1988.
24. Ryder K and Nathaus D: Induction of proto-oncogene cjun by serum growth factors. Proc Natl Acad Sci USA 85: 9464-9467, 1988.
25. Ryseck RP, Hirai SI, Yaniv M and Brauo R: Transcription activation of cjun during the GJG, transition in mouse fibroblasts. Nature 334: 535-537, 1988.
26. Castellazzi M, Dangy JP and Mechta F: Overexpression of avian or mouse cjun in primary chicken embryo fibroblasts confers a partially transformed phenotype. Oncogene 5: 1541-1547, 1990.
27. Wu WS, Lin JK and Wu FYH: Differential induction of c-fos and cjun proto- oncogenes and AP-1 activity by tumor promoter in cells at different stages of tumor promotion in vitro. Oncogene 7: 2287-2294, 1992.
28. Nishizukz Y: The family of protein kinase C for signal transduction. JAMA 262: 1826-1833, 1989.
29. Ransone LJ and Verma IM: Nuclear proto-oncogene fos and jun. Annu Rev Cell Biol 6: 539-557, 1989.
30. Nose K, Shibanuma M, Kikuchi K, Kageyama H, Sakiyama S and Kuroki T: Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line. Eur J Biochem 201: 99-106, 1991.
31. Amstad PA, Krupitza G and Cerutti PA: Mechanism of c-fos induction by active oxygen. Cancer Res 52: 3952-3960, 1992.
32. Shibanuma M, Kuroki T and Nose K: Induction of DNA replication and expression of proto-oncogene c-myc and c-fos in quiescent Balb/3T3 cells by xanthine/xanthine oxidase. Oncogene 3: 17-21, 1988.
33. Frenkel K: Oxidation of DNA bases by tumor promoter-activated processes. Environ Health Perspect 81: 45-54, 1986.
34. Shih CA and Lin JK: Inhibition of 8-hydroxydeoxyquanosine formation by curcumin in mouse fibroblast cells. Carcinogenesis 14: 709-712, 1993.
35. Witz G: Active oxygen species as factors in multistage carcinogenesis. Proc Soc. Exp Biol Med 52: 3952-3960, 1991.
36. Perchellet JP and Perchell EM: Antioxidant and multistage carcinogenesis in mouse skin. Free Rad Biol Med 7: 377-408, 1989.
37. Huang MT, Wang ZT, Georgiadis CA, Laskin JD and Conney AH: Inhibitory effects of curcumin on tumor initiation by benzo [a]pyrene and 7,12-dimethylbenz[a]anthracene. Carcinogenesis 13: 2183-2186, 1992.
38. Huang MT, Ho CT, Wang ZY, Ferraro T, Finnegan-Olive T and Lou YR: Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis 13: 947-954, 1992.
39. Chen LC, Sly L, Junes CS, Tarone R and Deluca LM: Differential effects of dietary β-carotene on papilloma and carcinoma formation induced by an initiation-promotion protocol in SENCAR mouse skin. Carcinogenesis 14: 713-717, 1993.
40. Tseng TH, Chu CY, Huang JM, Shiow SJ and Wang CJ: Crocetin protects against oxidative damage in primary hepatocyte. Cancer Lett 97: 61-67, 1995.