Electrophysiological properties of inferior olive neurons: A compartmental model

Journal of Neurophysiology

Volumn 82, Issue 2, 1999, Pages 804-817

  Schweighofer, Nicolas ^a   Doya, Kenji ^a   Kawato, Mitsuo ^a,b  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b ADVANCED TELECOMMUNICATIONS RESEARCH INSTITUTE INTERNATIONAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; POTASSIUM ION; SODIUM ION;

ARTICLE; CALCIUM CURRENT; COMPARTMENT MODEL; ELECTROPHYSIOLOGY; INFERIOR OLIVE; MATHEMATICAL ANALYSIS; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE CONDUCTANCE; OSCILLATION; POTASSIUM CURRENT; PRIORITY JOURNAL; PURKINJE CELL; SODIUM CURRENT; SPIKE;

EID: 0032785712     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1999.82.2.804     Document Type: Article

References (43)

1. ABARBANEL, H.D.I., HUERTA, R., RABINOVITCH, M. I., RULKOV, N. F., ROWAT, P. F., AND SELVERSTON, A. I. Synchronized action of synaptically coupled chaotic model of neurons. Neural Comp. 8: 1567-1602, 1996.
2. h. J. Neurophysiol. 77: 3145-3156, 1997.
3. BENARDO, L. S. AND FOSTER, R. E. Oscillatory behavior in inferior olive neurons: mechanism, modulation, cell aggregates. Brain Res. Bull. 17: 773-784, 1986.
4. BENNETT, M.V.L. AND VERSEDIS, V. K. Biophysics of gap junctions. Semin. Cell. Biol. 3: 29-47, 1992.
5. BLEASEL, A. F. AND PETTIGREW, A. G. The effect of bicarbonate free artificial cerebrospinal fluid on spontaneous oscillations of the membrane potential in inferior olivary neurons of the rat. Brain Res. 639: 8-20, 1994.
6. 2+-dependent spiking and plateau potentials under pharmacological treatment. J. Neurophysiol. 78: 3371-3385, 1997.
7. COHEN, S. D. AND HINDMARSH, A. C. CVODE User Guide. Lawrence Levermore National Laboratory, 1997.
8. CONDORELLI, D. F., PARENTI, R., SPINELLA, F., SALINARO, A. T., BELLUARDO, N., CARDILE, V., AND CICIRATA, F. Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons. Eur. J. Neurosci. 10: 1202-8, 1998.
9. DE ZEEUW, C. I., HOLSTEGE, J. C., RUIGROK, T. J., AND VOOGD, J. Ultrastructural study of the GABAergic, cerebellar, and mesodiencephalic innervation of the cat medial accessory olive: anterograde tracing combined with immunocytochemistry. J. Comp. Neural. 284: 12-35, 1989.
10. DE ZEEUW, C. I., LANG, E. J., SUGIHARA, I., RUIGROK, T. J., EISENMAN, L. M., MUGNAINI, E., AND LLINAS, R. Morphological correlates of bilateral synchrony in the rat cerebellar cortex. J. Neurosci. 16: 3412-3426, 1996.
11. DE ZEEUW, C. I., SIMPSON, J. I., HOOGENRAAD, C. C., GALJART, N., KOEKKOEK, S. K., AND RUIGROK, T. J. Microcircuitry and function of the inferior olive. Trends Neurosci. 21: 391-400, 1998.
12. DOEDEL, E. J. AUTO: a program for the automatic bifurcation analysis of autonomous systems. Proceedings of the 10th Manitoba Conference on Numerical Mathematics and Computation. Winnipeg: University of Manitoba, 1981, p. 265-284.
13. ERMENTROUT, B. XPPAUT3.0 - The Differential Equations Toll. University of Pittsburgh, 1997.
14. HUGUENARD, J. R. AND MCCORMICK, D. A. Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons. J. Neurophysiol. 68: 1373-1383, 1992.
15. KAWATO, M., SOKABE, M., AND SUZUKI, R. Synergism and antagonism of neurons caused by an electrical synapse. Biol. Cybern. 34: 81-89, 1979.
16. KEATING, J. G. AND THACH, W. T. Non-clock behavior of inferior olive neurons: interspike interval of Purkinje cell complex spike discharge in the awake behaving monkey is random. J. Neurophysiol. 73: 1329-1340, 1995.
17. KITAZAWA, S., KIMURA, T., AND YIN, P. B. Cerebellar complex spikes encode both destinations and errors in arm movements. Nature 392: 494-497, 1998.
18. KOBAYASHI, Y., KAWANO, K., TAKEMURA, A., INOUE, Y., KITAMA, T., GOMI, H., AND KAWATO, M. Temporal firing patterns of Purkinje cells in the cerebellar ventral paraflocullus during ocular following responses in monkeys. II. Complex spikes. J. Neurophysiol. 80: 832-848, 1998.
19. KOGAN, A. AND YAROM, Y. Electrotonic coupling in inferior olivary neurons revealed by direct measurements. Soc. Neurosci. Abstr. 507: 5, 1997.
20. LAMPL, I. AND YAROM, Y. Subthreshold oscillations and resonant behavior: two manifestations of the same mechanism. Neuroscience 78: 325-341, 1997.
21. LANG, E. J., SUGIHARA, I., AND LLINÁS, R. GABAergic modulation of complex spike activity by the cerebellar nucleoolivary pathway in the rat. J. Neurophysiol. 76: 255-275, 1996.
22. LLINÁS, R., BAKER, R., AND SOTELO, C. Electrotonic coupling between neurons in cat inferior olive. J. Neurophysiol. 37: 560-571, 1974.
23. LLINÁS, R. AND YAROM, Y. Electrophysiology of mammalian inferior olivary neurons in vitro. Different types of voltage-dependent ionic conductances. J. Physiol. (Lond.) 315: 549-567, 1981a.
24. LLINÁS, R. AND YAROM, Y. Properties and distribution of ionic conductances generating electroresponsiveness of mammalian inferior olivary neurons in vitro. J. Physiol. (Lond.) 315: 569-584, 1981b.
25. LLINÁS, R. AND YAROM, Y. Oscillatory properties of guinea pig inferior olivary neurons and their pharmacology modulation: an in-vitro study. J. Physiol. (Lond.) 376: 163-182, 1986.
26. MAINEN, Z. F. AND SEJNOWSKI, T. J. Influence of dendritic structure on firing pattern in model neocortical neurons. Nature 382: 363-366, 1996.
27. MANOR, Y. Construction of an Experimentally Based Neuronal Network Model to Explore the Function of the Inferior Olive Nucleus (PhD thesis). Jerusalem, Israel: Hebrew University, 1995.
28. MANOR, Y., RINZEL, J., SEGEV, I., AND YAROM, Y. Low-amplitude oscillations in the inferior olive: a model based on electrical coupling of neurons with heterogeneous channel densities. J. Neurophysiol. 77: 2736-2752, 1997.
29. MORENO, A. P., ROOK, M. B., FISHMA, G. I., AND SPRAY, D. C. Gap junction channels: distinct voltage-sensitive and -insensitive conductances states. Biophys. J. 67: 113-119, 1994.
30. PINSKY, P. F. AND RINZEL, J. Intrinsic and network rhythmogenesis in a reduced Traub model for CA3 neurons. J. Comp. Neurosci. 1: 39-60, 1994.
31. RINZEL, J. AND ERMENTROUT, G. B. Analysis of neural excitability and oscillations. In: Methods in Neuronal Modeling, edited by C. Koch and I. Segev. Cambridge, MA: The MIT Press, 1989, p. 135-170.
32. RUIGROK, T. J. AND VOOGD, J. Cerebellar influence on olivary excitability in the cat. Eur. J. Neurosci. 7: 679-693, 1995.
33. RUSH, M. E. AND RINZEL, J. Analysis of bursting in a thalamic neuron model. Biol. Cybern. 71: 281-284, 1994.
34. SASAKI, K., BOWER, J. M., AND LLINÁS, R. Multiple Purkinje cell recording in rodent cerebellar cortex. Eur. J. Neurosci. 1: 572-586, 1989.
35. SCHWEIGHOFER, N., SPOELSTRA, J., ARBIB, M. A., AND KAWATO, M. Role of the cerebellum in reaching movements in humans. II. A neural model of the intermediate cerebellum. Eur. J. Neurosci. 10: 95-105, 1998.
36. SHERMAN, A. AND RINZEL, J. Rhythmogenic effects of weak electrotonic coupling in neuronal models. Proc. Natl. Acad. Sci. USA 89: 2471-2474, 1992.
37. SIMPSON, J. I., WYLIE, D. R., AND DE ZEEUW, C. I. On climbing fiber functions and their consequences. Behav. Brain Sci. 19: 384-398, 1996.
38. SOTELO, C., LLINÁS, R., AND BAKER, R. Structural study of inferior olivary nucleus of the cat: morphological correlates of electrotonic coupling. J. Neurophysiol. 37: 541-559, 1974.
39. SUGIHARA, I., LANG, E. J., AND LLINÁS, R. Serotonin modulation of inferior olivary oscillations and synchronicity: a multiple-electrode study in the rat cerebellum. Eur. J. Neurcsci. 7: 521-534, 1995.
40. TRAUB, R. D., WONG, R.K.S., MILES, R., AND MICHELSON, H. A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances. J. Neurophysiol. 66: 635-650, 1991.
41. WEISS, M. AND PELLET, J. Raphe-cerebellum interactions. II. Effects of midbrain raphe stimulation and harmaline administration on single unit activity of cerebellar cortical cells in the rat. Exp. Brain Res. 48: 171-176, 1982.
42. YAROM Y. Rhythmogenesis in a hybrid system - interconnecting an olivary neuron to an analog network of coupled oscillators. Neuroscience 44: 263-275, 1991.
43. YAROM, Y. AND LLINÁS, R. Long term modifiability of anomalous and delayed rectification in guinea pig inferior olivary neurons. J. Neurosci. 1: 1166-1177, 1987.