Topical retinol improves cellulite

Journal of Dermatological Treatment

Volumn 10, Issue 2, 1999, Pages 119-125

  Kligman, A M ^a   Pagnoni, A ^b   Stoudemayer, T ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SKIN Inc   (United States)

Author keywords

Cellulite; Retinol

Indexed keywords

COLLAGEN; GLYCOSAMINOGLYCAN; RETINOL;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ECHOGRAPHY; FEMALE; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; LASER DOPPLER FLOWMETRY; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN BLOOD FLOW; SKIN CARE; THICKNESS; THIGH; TOPICAL DRUG ADMINISTRATION;

EID: 0032784661     PISSN: 09546634     EISSN: None     Source Type: Journal    
DOI: 10.3109/09546639909056013     Document Type: Article

References (14)

1. Nurnberger F, Muller G, So-called cellulite: an invented disease. J Dermatol Surg Oncol (1978) 4: 221-9.
2. Gasbarro V, Vettorello GF, Treating cellulite. Cosmet Toiletries (1992) 107: 64.
3. Di Salvo RM, Controlling the appearance of cellulite. Cosmetics and Toiletries Ingredient Resource Series, 1995, pp 21-7.
4. Smith W, Cellulite treatments: snake oils or skin science. Cosmet Toiletries (1995) 110: 61.
5. Curri SB, Cellulite and fatty tissue microcirculation. Cosmet Toiletries (1991) 108: 51.
6. Curri SB, Lymphoedema of cellulite. J Med Esthet (1983) 10: 11.
7. Nurnberger F, Muller G, Architectural structure of the subcutaneous layer and morphokinetics of "cellulite". In: Proceedings of the XIV International Congress of Dermatology, Padua-Venice, 22-27 May 1972. Excerpta Medica: Amsterdam, 1974, pp 868-9.
8. Schwartz E, Crueckshank FA, Mezick JA, Kligman AM, Topical all-trans retinoic acid stimulates collagen synthesis in vivo. J Invest Dermatol (1991) 96: 975-8.
9. Kligman AM, Grove GL, Hirose R, Leyden JJ, Topical tretinoin for photoaged skin. J Am Acad Dermatol (1986) 15: 836-59.
10. Kligman LH, Mezick JA, Capitola RJ, Thorne GE, Lifetime application of tretinoin to hairless mice. Acta Derm Venereol (1992) 72: 418.
11. Kurlandsky SB, Xiao JA, Duell EA, et al. Biological activity of all-trans retinol requires metabolic conversion to all-trans retinoic acid and is mediated through activation of nuclear retinoid receptors in human keratinocytes. J Biol Chem (1994) 269: 32821-7.
12. Duell EA, Kang S, Voorhees JJ, Unoccluded retinol penetrates human skin in vivo more effectively than unoccluded retinyl palmitate or retinoic acid. J Invest Dermatol (1997) 109: 301-5.
13. Kang J, Duell EA, Fisher GJ et al, Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J Invest Dermatol (1995) 105: 549.
14. Kligman AM, Dogadkina D, Lavker RM, Effects of topical tretinoin on non-sun-exposed protected skin of the elderly. J Am Acad Derm (1993) 29: 25-33.