Discordance between bone turnover and bone loss: Effects of aging and ovariectomy in the rat

Journal of Bone and Mineral Research

Volumn 14, Issue 8, 1999, Pages 1442-1448

  Baldock, Paul A J ^a,b   Need, Allan G ^a   Moore, Robert J ^a   Durbridge, Timothy C ^a   Morris, Howard A ^a,b  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE STRUCTURE; BONE TURNOVER; CANCELLOUS BONE; CELL ACTIVITY; CONTROLLED STUDY; FEMALE; FEMUR; FEMUR EPIPHYSIS; HORMONE DEFICIENCY; METAPHYSIS; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OVARIECTOMY; RAT; SCANNING ELECTRON MICROSCOPY; TRABECULAR BONE;

AGING; ANIMALS; BIOMECHANICS; BONE DEVELOPMENT; BONE RESORPTION; EPIPHYSES; FEMALE; FEMUR; OVARIECTOMY; OVARY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032784494     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1999.14.8.1442     Document Type: Article

References (25)

1. Stephan JJ, Pospichal J, Presl J, Pacovsky V 1987 Bone loss and biochemical indices of bone remodeling in surgically induced postmenopausal women. Bone 8:279-284.
2. Sims NA, Morris HA, Moore RJ, Durbridge TC 1996 Increased bone resorption precedes increased formation in the ovariectomized rat. Calcif Tissue Int 59:121-127.
3. Dempster DW, Birchman R, Xu R, Lindsay R, Shen V 1995 Temporal changes in cancellous bone structure of rats immediately after oophorectomy. Bone 16:157-161.
4. Wronski TJ, Clintrón M, Dann LM 1988 Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif Tissue Int 43:179-183.
5. Kalu DN 1991 The ovariectomized rat model of postmenopausal bone loss. Bone Miner 15:175-192.
6. Durbridge TC, Morris HA, Parsons AM, Parkinson IH, Moore RJ, Porter S, Need AG, Nordin BEC, Vernon-Roberts B 1990 Progressive cancellous bone loss in rats after adrenalectomy and oophorectomy. Calcif Tissue Int 47:383-387.
7. Wronski TJ, Dann LM, Horner SL 1989 Time course of vertebral osteopenia in ovariectomized rats. Bone 10:295-301.
8. Baldock PAJ, Morris HA, Need AG, Moore RJ, Durbridge TC 1998 Variation in the short-term changes in bone cell activity immediately following ovariectomy in three regions of the distal femur. J Bone Miner Res 13:1451-1457.
9. Westerlind KC, Wronski TJ, Ritman EL, Luo Z-P, An K-N, Bell NH, Turner RT 1997 Estrogen regulates the rate of bone turnover but bone balance in ovariectomized rats is modulated by prevailing mechanical strain. Proc Natl Acad Sci USA 94:4199-4204.
10. Yamazaki I, Yamaguchi H 1989 Characteristics of an ovariectomized osteopenic rat model. J Bone Miner Res 4:13-22.
11. Ikeda T, Yamaguchi A, Yokose S, Nagai Y, Yamato H, Nakamura T, Tsurukami H, Tanizawa T, Yoshiki S 1996 Changes in biological activity of bone cells in ovariectomized rats revealed by in situ hybridisation. J Bone Miner Res 11:780-788.
12. Martin RB, Zissimos SL 1991 Relationships between marrow fat and bone turnover in ovariectomized and intact rats. Bone 12:123-131.
13. Frost HM 1996 Perspective: A proposed general model of the "mechanostat" (suggestions from a new skeletal-biologic paradigm). Anat Rec 244:139-147.
14. Parfitt AM, Mathews CHE, Villanueva AR, Kleerekoper M, Frame B, Rao DS 1983 Relationships between surface, volume and thickness of iliac trabecular bone in ageing and in osteoporosis: Implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest 72:1396-1409.
15. Baldock PAJ, Moore RJ, Durbridge TC, Morris HA 1999 Comparison of three methods for estimation of bone resorption following ovariectomy in the distal femur and proximal tibia of the rat. Bone 24:597-602.
16. Eriksen EF, Axelrod DW, Melsen F 1994 Bone Histomorphometry. Raven Press, New York, NY, U.S.A., pp. 39-48.
17. Li M, Shen Y, Wronski TJ 1997 Time course of femoral neck osteopenia in ovariectomized rats. Bone 20:55-61.
18. Wronski TJ, Dann LM, Scott KS, Clintrón M 1989 Long-term effects of oophorectomy and aging on the rat skeleton. Calcif Tissue Int 45:360-366.
19. Recker RR, Kimmel DB, Parfitt AM, Davies KM, Keshawarz N, Hinders S1988 Static and tetracycline-based bone histomorphometric data from 34 normal postmenopausal females. J Bone Miner Res 3:133-144.
20. Thomsen JS, Mosekilde L, Boyce RW, Mosekilde E 1994 Stochastic simulation of vertebral trabecular bone remodeling. Bone 15:655-666.
21. Parfitt AM 1988 Bone remodeling: Relationship to the amount and structure of bone and the pathogenesis and prevention of fractures. In: Riggs BL, Melton LJ (eds.) Osteoporosis: Etiology, Diagnosis and Management. Raven Press, New York, NY, U.S.A., pp. 45-93.
22. Nordin BEC, Need AG, Chatterton BE, Horowitz M, Morris HA 1990 The relative contributions of age and years since menopause to postmenopausal bone loss. J Clin Endocrinol Metab 70:183-188.
23. Peng Z-Q, Väänänen HK, Zhang HX, Tuukkanen J 1997 Long-term effects of oophorectomy on the mechanical properties and chemical composition of rat bone. Bone 20:207-212.
24. Baldock PAJ, Morris HA, Moore RJ, Durbridge TC 1998 Prepubertal oophorectomy limits the accumulation of cancellous bone in the femur of growing rats with long term effects on metaphyseal bone architecture. Calcif Tissue Int 62:244-249.
25. Bourrin S, Palle S, Pupier R, Vico L, Alexandre C 1995 Effects of physical training on bone adaption in three zones of the rat tibia. J Bone Miner Res 10:1745-1752.