Critical properties of lactide-co-glycolide polymers for the use in microparticle preparation by the Aerosol Solvent Extraction System

International Journal of Pharmaceutics

Volumn 185, Issue 1, 1999, Pages 61-72

  Engwicht, A ^a   Girreser, U ^a   Muller B W ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Microparticles; NMR; Polylactide co glycolide; Powder diffraction; Supercritical fluids; Thermal analysis

Indexed keywords

COPOLYMER; ESTRIOL; GLYCOLIC ACID; POLOXAMER; POLYGLACTIN; POLYMER; SERUM ALBUMIN;

ARTICLE; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DIFFRACTION; DRUG DOSAGE FORM; DRUG RELEASE; EXTRACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; POWDER; PRIORITY JOURNAL; THERMAL ANALYSIS;

AEROSOLS; BIOCOMPATIBLE MATERIALS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; HUMANS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; PROSTHESES AND IMPLANTS; SOLVENTS;

EID: 0032783562     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00127-1     Document Type: Article

References (8)

1. Braun S., Kalinowski H.-O., Berger S. 100 and More Basic NMR Experiments - A Practical Course. 1996;234f Verlag Chemie, Weinheim.
2. Engwicht, A., Girreser, U., Müller, B.W., 1998. Characterization of co-polymers of lactic and glycolic acid by means of NMR spectroscopy, in press.
3. Harland R.S., Peppas N.A. Drug transport in and release from controlled delivery devices of hydrophilic/hydrophobic block and graft polymers. J. Pharm. Biopharm. 39:1993;229-233.
4. Kricheldorf H.R., Kreiser I. Kationic copolymerization of glycolide with L,L-dilactide. Makromol. Chem. 188:1987;1861-1873.
5. Li S., Rashkov I., Espartero J.L., Monolova N., Vert M. Synthesis, charactrization, and hydrolytic degradation of PLA/PEO/PLA triblock copolymers with long poly(L-lactic acid) blocks. Macromolecules. 29:1996;57-62.
6. Müller, B.W., Fischer, W., 1991. Method and apparatus for the manufacture of a product having a substance embedded in a carrier. US patent No. 5,043,280.
7. Rafler, G, Müller, B.W., 1996. Verfahren zur Herstellung biologisch abbaubarer Polyester, EP-PS 0 573 024.
8. Tice T.R., Gilley R.M. Preparation of injectable controlled release microcapsules by a a solvent evaporation process. J. Control. Rel. 2:1985;343-352.