Effect of over-the-counter cimetidine on phenytoin concentrations in patients with seizures

Annals of Pharmacotherapy

Volumn 33, Issue 7-8, 1999, Pages 769-774

  Rafi, John A ^a,b   Frazier, Lisa M ^c   Driscoll Bannister, Susan M ^d   O'Hara, Kathryn A ^d   Garnett, William R ^d   Pugh, Carol B ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c Division of Managed Care Resources   (United States)

^d NONE

Author keywords

Cimetidine; Over the counter; Phenytoin

Indexed keywords

CARBAMAZEPINE; CIMETIDINE; NON PRESCRIPTION DRUG; PHENOBARBITAL; PHENYTOIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; FEMALE; HUMAN; LONG TERM CARE; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SEIZURE;

EID: 0032783066     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.18314     Document Type: Article

References (16)

1. Zoeller J. I recommend: pharmacists pick the top OTCs. Am Druggist 1998;215(7):37-8,40-3.
2. Anderson GD. A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother 1998;32:554-63.
3. Winter ME, Tozer TN. Phenytoin. In: Evans WE, Schentag JJ, Jusko WJ, eds. Applied pharmacokinetics: principles of therapeutic drug monitoring. 3rd ed. Spokane, WA: Applied Therapeutics, Inc., 1992:25-1 to 25-44.
4. Package insert. Tagamet HB (cimetidine). Pittsburgh, PA: SmithKline Beecham Consumer Healthcare, L.P., 1996.
5. Neuvonen PJ, Tokola RA, Kaste M. Cimetidine-phenytoin interaction: effect upon serum phenytoin concentration and antipyrine test. Eur J Clin Pharmacol 1981;21:215-20.
6. Hetzel DJ, Bochner F, Hallpike JF, Shearman DJC, Hann CS. Cimetidine interaction with phenytoin. Br Med J 1981;282:1512.
7. Frigo GM, Lecchini S, Caravaggi M, Gatti G, Tonini M, D'Angelo L, et al. Reduction in phenytoin clearance caused by cimetidine. Eur J Clin Pharmacol 1983;25:135-7.
8. Bartle WR, Walker SE Shapero T. Dose-dependent effect of cimetidine on phenytoin kinetics. Clin Pharmacol Ther 1983;33:649-55.
9. Iteogu MO, Murphy JE, Shleifer N, Davis R. Effect of cimetidine on single-dose phenytoin kinetics (letter). Clin Pharm 1983;2:302-4.
10. Levine M, Jones MW, Sheppard I. Differential effect of cimetidine on serum concentrations of carbamazepine and phenytoin. Neurology 1985; 35:562-5.
11. Anticonvulsants, hydantoin (systemic). In: USP DI 1998 - drug information for the health care professional. 18th ed. Rockville MD: The United States Pharmacopeial Convention, Inc., 1998:242.
12. Sheiner LB, Beal SL. Some suggestions for measuring predictive performance. J Pharmacokinet Biopharm 1981;9:503-12.
13. Choi SC. Introductory applied statistics in science. Englewood Cliffs, NJ: Prentice-Hall Inc., 1978:169-74.
14. Rambeck B, May TW, Jürgens U, Blankenhorn V, Jürges U, Korn-Merker E, et al. Comparison of phenytoin and carbamazepine serum concentrations measured by high-performance liquid chromatography, the standard TDx assay, the enzyme multiplied immunoassay technique, and a new patient-side immunoassay cartridge system. Ther Drug Monit 1994;16:608-12.
15. Miller LG. Cigarettes and drug therapy: pharmacokinetic and pharmacodynamic considerations. Clin Pharm 1990;9:125-35.
16. Colton T. Statistics in medicine. Boston: Little, Brown and Company, 1974:144.