The influence of engravings on the sticking of tablets. Investigations with an instrumented upper punch

Pharmaceutical Development and Technology

Volumn 4, Issue 3, 1999, Pages 369-375

  Waimer, Frank ^a   Krumme, Markus ^a   Danz, Peter ^b   Tenter, Ulrich ^c   Schmidt, Peter C ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b BAYER AG   (Germany)

^c MEDA Manufacturing GmbH   (Germany)

Author keywords

Adhesion force; Engraving; Engraving shear force; Single punch instrumentation; Sticking of tablets; Tablet identification

Indexed keywords

ACETYLSALICYLIC ACID; SORBITOL; STARCH;

ADHESION; ARTICLE; COMPRESSION; CONTROLLED STUDY; DRUG FORMULATION; DRUG MANUFACTURE; LUBRICATION; PRINTING; PRIORITY JOURNAL; SHEAR STRESS; TABLET;

ADHESIVENESS; CELLULOSE; DRUG COMPOUNDING; EXCIPIENTS; LACTOSE; ONLINE SYSTEMS; PRESSURE; RHEOLOGY; STARCH; SURFACE PROPERTIES; TABLETS;

EID: 0032782318     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100101372     Document Type: Article

References (11)

1. D. Train, Transmission of forces through a powder mass during the process of pelleting, Trans. Inst. Chem. Eng., 35, 258-266 (1957).
2. D. Train and J. A. Hersey, Some fundamental studies in the cold compaction of plastically deforming solids, Powder Metall., 6, 20-35 (1960).
3. E. N. Hiestand, J. E. Wells, C. B. Peot, and J. F. Ochs, Physical processes of tableting, J. Pharm. Sci., 66, 510-519 (1977).
4. th ed., American Pharmaceutical Association, Washington, DC, 1995.
5. F. Waimer, M. Krumme, P. Danz, U. Tenter, and P. C. Schmidt, A novel method for the detection of sticking of tablets, Pharm. Dev. Technol., 4(3) 359-367 (1999).
6. D. N. Travers, M. Çelik, and T. C. Buttery, A computer aided investigation on strain movement in compacts under constant stress within the die, Drug. Dev. Ind. Pharm., 9, 139-157 (1983).
7. S. Esezobo and N. Pilpel, Effects of applied load and particle size on the plastoelasticity and tablet strength of some directly compressible powders, J. Pharm. Pharmacol., 39, 303-304 (1987).
8. E. T. Cole, J. E. Rees, and J. A. Hersey, Relations between compaction data for some crystalline pharmaceutical materials, Pharm. Acta Helv., 50, 28-32 (1975).
9. R. Ek., P. Wormald, J. Östelius, T. Iversen, and C. Nyström, Crystallinity indices of microcrystalline cellulose particles compressed into tablets, Int. J. Pharm., 125, 257-264 (1995).
10. R. Hüttenrauch and I. Keiner, Molekulargalenik 11. Mitteilung: Einfluss des Pressdrucks auf den Ordnungsgrad von Cellulosepulvern, Pharmazie, 31, 490-491 (1976).
11. J. Gravitis, A. Kokorevics, R. Zeeäär, A. Zharov, and E. Lippmaa, Structural changes of wood and its components initiated by simultaneous action of shear deformation and high pressure, J. Pulp Paper Sci., 17, 199-123 (1991).