Endopeptidases (kininases) are able to hydrolyze kinins in tubular fluid along the rat nephron

American Journal of Physiology - Renal Physiology

Volumn 277, Issue 1 46-1, 1999, Pages

  Casarini, D E ^a   Boim, M A ^a   Stella, R C R ^a   Schor, N ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Angiotensin 1 converting enzyme; Bradykinin; Exopeptidases; Kallikrein kinin system; Micropuncture; Neutral endopeptidase; Prolyl endopeptidase; Serine endopeptidase

Indexed keywords

BRADYKININ; CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE; KALLIKREIN; KININ; KININASE; MEMBRANE METALLOENDOPEPTIDASE; PEPTIDASE; PROLYL ENDOPEPTIDASE; PROTEINASE; SERINE PROTEINASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; KALLIKREIN KININ SYSTEM; KIDNEY TUBULE; LIQUID; MALE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; RAT; URINE;

EID: 0032782303     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1999.277.1.f66     Document Type: Article

References (28)

1. Almenoff, J., and M. Orlowski. Membrane-bound kidney neutral metalloendopeptidase: interaction with synthetic substrates, natural peptides and inhibitors. Biochemistry 22: 590-599, 1983.
2. Alonzo, N., and V. Hirs. Automation of sample application in amino acid analyzes. Anal. Biochem. 23: 272-288, 1968.
3. Andreucci, V. E. Collection of tubular fluid samples from superficial tubules. In: Manual of Renal Micropuncture, edited by V. E. Andreucci. Naples, Italy: Idelson, 1978, p. 128-150.
4. Barret, A. J. The many forms and function of cellular proteinases. Federation Proc. 39: 9-14, 1980.
5. Boim, M. A., H. Ajzen, O. L. Ramos, and N. Schor. Glomerular hemodynamics and hormone evaluation during starvation in rats. Kidney Int. 42: 567-572, 1992.
6. Carone, F. A., T. N. Pullman, S. Oparil, and S. Nakamura. Micropuncture evidence of rapid hydrolysis of bradykinin by rat proximal tubule. Am. J. Physiol. 230: 1420-1424, 1976.
7. Casarini, D. E., R. C. R. Stella, K. B. Alves, and M. S. Araujo. Rat urine kininases: a comparison with human urine. Proc. IV PAABS Congress, São Paulo, Brasil, 1990.
8. Casarini, D. E., K. B. Alves, M. S. Araujo, and R. C. R. Stella. Endopeptidase and carboxypeptidase activities in human urine which hydrolyze bradykinin. Braz. J. Med. Biol. Res. 25: 219-229, 1992.
9. Casarini, D. E., M. A. Boim, M. Krieger-Azzolin, J. E. Krieger, R. C. R. Stella, and N. Schor. Angiotensin converting enzyme along the rat nephron. Am. J. Physiol. 272 (Renal Physiol. 41): F405-F409, 1997.
10. Erdös, E. G. Some old and new ideas on kinin metabolism. J. Card. Pharmacol. 15, Suppl. 6: 520-524, 1990.
11. Erdös, E. G., and H. Y. T. Yang. Inactivation and potentiation of the effects of bradykinin. In: Hypotensive Peptides, edited by E. G. Erdös, N. Back, F. Sicuteri and A. F. Wilde. New York: Springer-Verlag, 1966, p. 235-251.
12. Erdös, E. G., and H. Y. T. Yang. Kininase. In: Handbook of Experimental Pharmacology, Bradykinin, Kallidin and Kallikrein, edited by E. G. Erdös. New York: Springer-Verlag, 1970, vol. XXV, p. 289-323.
13. Ferreira, S. H., and J. R. Vane. The disappearance of bradykinin and eledoisin in the circulation and vascular beds of the cat. Br. J. Pharmacology 30: 417-424, 1967.
14. Fuhr, J., J. Kaczmarezyk, and C. D. Kruttjen. Eine einfache colorimetrische Methode zur Inulinbestimmung fur Nierenclearanceuntersuchungen bei soffwechselgesuchen und diabetikern. Klinic Wochenschr. 33: 729-730, 1955.
15. Gafford, J. T., R. A. Skidgel, E. G. Erdös, and L. B. Hersh. Human kidney enkephalinase, a neutral endopeptidase that cleaves active peptides. Biochemistry 22: 3265-3271, 1983.
16. Guder, W. G., and J. Hallbach. Localization and regulation of the renal kallikrein-kinin system: possible relations to renal transport functions. Klin. Wochenschr. 66: 849-856, 1988.
17. Kerr, M. A., and A. J. Kenny. The purification and specificity of a neutral endopeptidase from rabbit kidney brush border. Biochem. J. 137: 477-488, 1974.
18. Koida, M., and R. Walter. Post-proline cleaving enzyme. J. Biol. Chem. 251: 7593-7599, 1976.
19. Marchetti, J., J. Rosseau, and F. Alhenc-Gelas. Angiotensin converting enzyme and kinin-hydrolyzing enzymes along the rabbit nephron. Kidney Int. 31: 744-751, 1987.
20. McCarthy, D. A., D. E. Potter, and E. D. Nicolaides. An in vivo estimation of the potencies and half lives of synthetic bradykinin and kallidin. J. Pharmacol. Exp. Ther. 148: 117-122, 1965.
21. Proud, D., M. Perkins, J. V. Pierce, N. Yates, F. Highet, P. L. Herring, M. Mangkornknok Mark, R. Bahu, F. Carone, and J. J. Pisano. Characterization and localization of human renal kininogen. J. Biol. Chem 256: 10634-10639, 1981.
22. Scicli, A. G., and O. A. Carretero. Renal kallikrein-kinin system. Kidney Int. 19: 120-130, 1986.
23. Ura, N., O. A. Carretero, and E. G. Erdös. Role of renal endopeptidase, 24.11 in kinin metabolism in vitro and in vivo. Kidney Int. 32: 507-513, 1987.
24. Vio, C. P., C. D. Figueiroa, and I. Caorsi. Anatomical relationship between kallikrein-containing tubules and juxtaglomerular apparatus in the human kidney. Am. J. Hypertens. 1: 269-271, 1988.
25. Vurek, G. G., and S. E. Pegran. Fluorimetric method for the determination of nanogram quantities of inulin. Anal. Biochem. 16: 409-419, 1966.
26. Ward, P. E., E. G. Erdös, C. D. Gedney, R. M. Dowben, and R. C. Reynolds. Isolation of membrane bound renal enzymes that metabolize kinins and angiotensins. Biochem. J. 157: 643-650, 1976.
27. Ward, P. E., W. Schultz, R. C. Reynolds, and E. G. Erdös. Metabolism of kinins and angiotensins in the isolated glomerulus and brush border of rat kidney. Lab. Invest. 36: 599-606, 1977.
28. Ward, P. E., and M. S. Sheridan. Converting, kininase and angiotensinase of renal and intestinal brush border. In: Kinin III, edited by H. Fritz and N. Back. New York: Plenun, 1983, part b, p. 835.