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Volumn 85, Issue 4, 1999, Pages 85-91

Effect of 3,4,5-trimethoxybenzoic acid 8-diethylamino-octyl ester (TMB- 8) on neuronal calcium homeostasis, protein synthesis, and energy metabolism

Author keywords

[No Author keywords available]

Indexed keywords

3,4,5 TRIMETHOXYBENZOIC ACID 8 (DIETHYLAMINO)OCTYL ESTER; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; BENZOIC ACID DERIVATIVE; CAFFEINE; CALCIUM; PROTEIN; RYANODINE RECEPTOR;

EID: 0032782047     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1999.tb00071.x     Document Type: Article
Times cited : (11)

References (42)
  • 1
    • 0022939374 scopus 로고
    • Energy metabolism in delayed neuronal death of CA1 neurones of the hippocampus following transient ischaemia in the gerbil
    • Arai, H., J. V. Passonneau & W. D. Lust: Energy metabolism in delayed neuronal death of CA1 neurones of the hippocampus following transient ischaemia in the gerbil. Metabol. Brain Dis. 1986, 1, 263-278.
    • (1986) Metabol. Brain Dis. , vol.1 , pp. 263-278
    • Arai, H.1    Passonneau, J.V.2    Lust, W.D.3
  • 2
    • 0029416843 scopus 로고
    • The "calcium antagonist" TMB-8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester] is a potent, non-competetive, functional antagonist at diverse nicotinic acetylcholine receptor subtypes
    • Bencherif, M., C. M. Eisenhour, R. J. Prince, P. M. Lippiello & R. J. Lukas: The "calcium antagonist" TMB-8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester] is a potent, non-competetive, functional antagonist at diverse nicotinic acetylcholine receptor subtypes. J. Pharmacol. Exp. Therap. 1995, 275, 1418-1426.
    • (1995) J. Pharmacol. Exp. Therap. , vol.275 , pp. 1418-1426
    • Bencherif, M.1    Eisenhour, C.M.2    Prince, R.J.3    Lippiello, P.M.4    Lukas, R.J.5
  • 4
    • 0021676903 scopus 로고
    • The intracellular calcium antagonist TMB-8 [8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate inhibits mitochondrial ATP production in rat thymocytes
    • Brand, M. D. & S. M. Felber: The intracellular calcium antagonist TMB-8 [8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate inhibits mitochondrial ATP production in rat thymocytes. Biochem. J. 1984, 224, 1027-1030.
    • (1984) Biochem. J. , vol.224 , pp. 1027-1030
    • Brand, M.D.1    Felber, S.M.2
  • 5
    • 0025326163 scopus 로고
    • Calcium dependent regulation of protein synthesis in intact mammalian cells
    • Brostrom, M. A. & C. O. Brostrom: Calcium dependent regulation of protein synthesis in intact mammalian cells. Ann. Rev. Physiol. 1990, 52, 557-590.
    • (1990) Ann. Rev. Physiol. , vol.52 , pp. 557-590
    • Brostrom, M.A.1    Brostrom, C.O.2
  • 6
    • 0028880882 scopus 로고
    • Prevention and reduction of neuronal damage in ischaemic strokes by w-(N,N′-diethylamino)-n-alkyl-3,4,5-trimethoxybenzoate compounds
    • Chiou, G. C. Y. & S.-J. Hong: Prevention and reduction of neuronal damage in ischaemic strokes by w-(N,N′-diethylamino)-n-alkyl-3,4,5-trimethoxybenzoate compounds. J. Pharmacol. Exp. Therap. 1995, 275, 474-478.
    • (1995) J. Pharmacol. Exp. Therap. , vol.275 , pp. 474-478
    • Chiou, G.C.Y.1    Hong, S.-J.2
  • 7
    • 0016654038 scopus 로고
    • 2+ antagonist, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride in smooth and skeletal muscles
    • 2+ antagonist, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride in smooth and skeletal muscles. Brit. J. Pharmacol. 1974, 53, 279-285.
    • (1974) Brit. J. Pharmacol. , vol.53 , pp. 279-285
    • Chiou, C.Y.1    Malagodi, M.H.2
  • 8
    • 0029844856 scopus 로고    scopus 로고
    • Long-lasting neuroprotective effect of postischaemic hypothermia and treament with anti-inflammatory/antipyretic drug - Evidence for chronic encephalopathic processes following ischaemia
    • Coimbra, C., M. Drake, F. Borismoller & T. Wieloch: Long-lasting neuroprotective effect of postischaemic hypothermia and treament with anti-inflammatory/antipyretic drug - evidence for chronic encephalopathic processes following ischaemia. Stroke 1996, 27, 1578-1585.
    • (1996) Stroke , vol.27 , pp. 1578-1585
    • Coimbra, C.1    Drake, M.2    Borismoller, F.3    Wieloch, T.4
  • 9
    • 0029838333 scopus 로고    scopus 로고
    • Global brain ischaemia and reperfusion: Modifications in eukaryotic initiation factors associated with inhibition of translational initiation
    • DeGracia, D. J., R. W. Neumar, B. C. White & G. S. Krause: Global brain ischaemia and reperfusion: modifications in eukaryotic initiation factors associated with inhibition of translational initiation. J. Neurochem. 1996, 67, 2005-2012.
    • (1996) J. Neurochem. , vol.67 , pp. 2005-2012
    • DeGracia, D.J.1    Neumar, R.W.2    White, B.C.3    Krause, G.S.4
  • 10
    • 0031461668 scopus 로고    scopus 로고
    • Regulation of neuronal endoplasmic reticulum calcium homeostasis to ribosomal aggregation and protein synthesis: Implications for stress-induced suppression of protein synthesis
    • Doutheil, J., C. Gissel, U. Oschlies, K.-A. Hossmann & W. Paschen: Regulation of neuronal endoplasmic reticulum calcium homeostasis to ribosomal aggregation and protein synthesis: implications for stress-induced suppression of protein synthesis. Brain Res. 1997, 775, 43-51.
    • (1997) Brain Res. , vol.775 , pp. 43-51
    • Doutheil, J.1    Gissel, C.2    Oschlies, U.3    Hossmann, K.-A.4    Paschen, W.5
  • 11
    • 0030967794 scopus 로고    scopus 로고
    • Activation of heme oxygenase-1 expression by disturbances of endoplasmic reticulum calcium stores in rat neuronal cell culture
    • Gissel, C., J. Doutheil & W. Paschen: Activation of heme oxygenase-1 expression by disturbances of endoplasmic reticulum calcium stores in rat neuronal cell culture. Neurosci. Lett. 1997a, 231, 1-4.
    • (1997) Neurosci. Lett. , vol.231 , pp. 1-4
    • Gissel, C.1    Doutheil, J.2    Paschen, W.3
  • 12
    • 0030689637 scopus 로고    scopus 로고
    • Temporal analysis of changes in neuronal c-fos mRNA levels induced by depletion of endoplasmic reticulum calcium stores: Effect of clamping cytoplasmic calcium activity at resting levels
    • Gissel, C., J. Doutheil & W. Paschen: Temporal analysis of changes in neuronal c-fos mRNA levels induced by depletion of endoplasmic reticulum calcium stores: effect of clamping cytoplasmic calcium activity at resting levels. J. Neurochem. 1997b, 69, 2538-2545.
    • (1997) J. Neurochem. , vol.69 , pp. 2538-2545
    • Gissel, C.1    Doutheil, J.2    Paschen, W.3
  • 13
    • 0024852744 scopus 로고
    • Differential allosteric effects of 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate-HCl (TMB-8) on muscarinic receptor subtypes
    • Gordon, R. K. & P. K. Chiang: Differential allosteric effects of 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate-HCl (TMB-8) on muscarinic receptor subtypes. FEBS Lett. 1989, 257, 383-387.
    • (1989) FEBS Lett. , vol.257 , pp. 383-387
    • Gordon, R.K.1    Chiang, P.K.2
  • 15
    • 0021895138 scopus 로고
    • 2+ indicators with greatly improved fluorescence properties
    • 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985, 260, 3440-3450.
    • (1985) J. Biol. Chem. , vol.260 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 16
    • 0025028894 scopus 로고
    • TMB-8 as a pharmacologic tool in guinea pig myocardial tissue. II. Effects of TMB-8 on membrane currents in isolated ventricular cardiomyocytes
    • Himmel, H. M. & U. Ravens: TMB-8 as a pharmacologic tool in guinea pig myocardial tissue. II. Effects of TMB-8 on membrane currents in isolated ventricular cardiomyocytes. J. Pharmacol. Exp. Therap. 1990, 255, 300-304.
    • (1990) J. Pharmacol. Exp. Therap. , vol.255 , pp. 300-304
    • Himmel, H.M.1    Ravens, U.2
  • 17
    • 0027458860 scopus 로고
    • Technique for in situ measurement of calcium in intracellular inositol 1,4,5,-trisphosphate-sensitive stores using the fluorescent indicator mag-fura-2
    • Hofer, A. M. & T. E. Machen: Technique for in situ measurement of calcium in intracellular inositol 1,4,5,-trisphosphate-sensitive stores using the fluorescent indicator mag-fura-2. Proc. Natl. Acad. Sci. 1993, 90, 2598-2602.
    • (1993) Proc. Natl. Acad. Sci. , vol.90 , pp. 2598-2602
    • Hofer, A.M.1    Machen, T.E.2
  • 18
    • 0027298139 scopus 로고
    • Disturbances of protein synthesis and ischaemic cell death
    • Hossmann, K.-A.: Disturbances of protein synthesis and ischaemic cell death. Progr. Brain Res. 1993, 96, 161-177.
    • (1993) Progr. Brain Res. , vol.96 , pp. 161-177
    • Hossmann, K.-A.1
  • 19
    • 0020051129 scopus 로고
    • Delayed neuronal death in the gerbil hippocampus following ischaemia
    • Kirino, T.: Delayed neuronal death in the gerbil hippocampus following ischaemia. Brain Res. 1982, 239, 57-69.
    • (1982) Brain Res. , vol.239 , pp. 57-69
    • Kirino, T.1
  • 20
    • 0016719872 scopus 로고
    • Resuscitation of the monkey brain after one hour complete ischaemia: III. Indications of metabolic recovery
    • Kleihues, P., K.-A. Hossmann, A.E. Pegg, K. Kobayashi & V. Zimmermann: Resuscitation of the monkey brain after one hour complete ischaemia: III. Indications of metabolic recovery. Brain Res. 1975, 95, 61-73.
    • (1975) Brain Res. , vol.95 , pp. 61-73
    • Kleihues, P.1    Hossmann, K.-A.2    Pegg, A.E.3    Kobayashi, K.4    Zimmermann, V.5
  • 21
    • 0031048249 scopus 로고    scopus 로고
    • Neuroprotective nitric oxide synthase inhibitor reduces intracellular calcium accumulation following transient global ischsemia in the gerbil
    • Kohno, K., T. Higuchi, S. Ohta, K. Kohno, Y. Kumon & S. Sakaki: Neuroprotective nitric oxide synthase inhibitor reduces intracellular calcium accumulation following transient global ischsemia in the gerbil. Neurosci. Lett. 1997, 224, 17-20.
    • (1997) Neurosci. Lett. , vol.224 , pp. 17-20
    • Kohno, K.1    Higuchi, T.2    Ohta, S.3    Kohno, K.4    Kumon, Y.5    Sakaki, S.6
  • 22
    • 0027438582 scopus 로고
    • Enhancement of cell killing and increase in cytosolic caleivm concentration by combined treatment with hyperthermia and TMB-8 in mouse mammary carcinoma FM3A cells
    • Kondo, T., E. Kano, Y. Habara & T. Kanno: Enhancement of cell killing and increase in cytosolic caleivm concentration by combined treatment with hyperthermia and TMB-8 in mouse mammary carcinoma FM3A cells. Cell Calcium 1993, 14, 621-629.
    • (1993) Cell Calcium , vol.14 , pp. 621-629
    • Kondo, T.1    Kano, E.2    Habara, Y.3    Kanno, T.4
  • 23
    • 0026670151 scopus 로고
    • Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol
    • Kuznetsov, G., M. A. Brostrom & C. O. Brostrom: Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol. J. Biol. Chem. 1992, 267, 3932-3939.
    • (1992) J. Biol. Chem. , vol.267 , pp. 3932-3939
    • Kuznetsov, G.1    Brostrom, M.A.2    Brostrom, C.O.3
  • 24
    • 0025313861 scopus 로고
    • Perturbation of cellular calcium blocks exit of secretory proteins from rough endoplasmic reticulum
    • Lodish, H. F. & N. Kong: Perturbation of cellular calcium blocks exit of secretory proteins from rough endoplasmic reticulum. J. Biol. Chem. 1990, 265, 10893-10899.
    • (1990) J. Biol. Chem. , vol.265 , pp. 10893-10899
    • Lodish, H.F.1    Kong, N.2
  • 25
    • 0026654505 scopus 로고
    • Calcium is required for folding of newly made subunits of the asialoglycoprotein receptor within the endoplasmic reticulum
    • Lodish, H. F., N. Kong & L. Wikström: Calcium is required for folding of newly made subunits of the asialoglycoprotein receptor within the endoplasmic reticulum. J. Biol. Chem. 1992, 267, 12753-12760.
    • (1992) J. Biol. Chem. , vol.267 , pp. 12753-12760
    • Lodish, H.F.1    Kong, N.2    Wikström, L.3
  • 27
    • 0016235597 scopus 로고
    • ++ antagonist, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride (TMB-8): Studies in skeletal muscles
    • ++ antagonist, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride (TMB-8): studies in skeletal muscles. Pharmacol. 1974, 12, 20-31.
    • (1974) Pharmacol. , vol.12 , pp. 20-31
    • Malagodi, M.H.1    Chiou, C.Y.2
  • 28
    • 0029895779 scopus 로고    scopus 로고
    • A prototypic intracellular calcium antagonist, TMB-8, protects cultured cerebellar granule cells against the delayed, calcium-dependent component of glutamate neurotoxicity
    • Malcolm, C. S., L. Ritchie, A. Grieve & R. Griffiths: A prototypic intracellular calcium antagonist, TMB-8, protects cultured cerebellar granule cells against the delayed, calcium-dependent component of glutamate neurotoxicity. J. Neurochem. 1996, 66, 2350-2360.
    • (1996) J. Neurochem. , vol.66 , pp. 2350-2360
    • Malcolm, C.S.1    Ritchie, L.2    Grieve, A.3    Griffiths, R.4
  • 30
    • 0028819074 scopus 로고
    • TMB-8 and dibucaine induce tyrosine phosphorylation and dephosphorylation of a common set of proteins in platelets
    • Oda, A., B. J. Druker, H. Ariyoshi, M. Smith & E. W. Salzman: TMB-8 and dibucaine induce tyrosine phosphorylation and dephosphorylation of a common set of proteins in platelets. Amer. J. Physiol. 1995, 269 (1 Pt 1), C118-C125.
    • (1995) Amer. J. Physiol. , vol.269 , Issue.1 PART 1
    • Oda, A.1    Druker, B.J.2    Ariyoshi, H.3    Smith, M.4    Salzman, E.W.5
  • 31
    • 0026785244 scopus 로고
    • Calcium-independent effects of TMB-8. Modification of phospholipid metabolism in neuroblastoma cells by inhibition of choline uptake
    • Palmer, F. B., D. M. Byers, M. W. Spence & H. W. Cook: Calcium-independent effects of TMB-8. Modification of phospholipid metabolism in neuroblastoma cells by inhibition of choline uptake. Biochem, J. 1992, 286 (Pt 2), 505-512.
    • (1992) Biochem. J. , vol.286 , Issue.PART 2 , pp. 505-512
    • Palmer, F.B.1    Byers, D.M.2    Spence, M.W.3    Cook, H.W.4
  • 32
    • 0029851855 scopus 로고    scopus 로고
    • Disturbances in calcium homeostasis within the endoplasmic reticulum may contribute to the development of ischaemic cell damage
    • Paschen, W.: Disturbances in calcium homeostasis within the endoplasmic reticulum may contribute to the development of ischaemic cell damage. Med. Hypoth. 1996, 47, 283-288.
    • (1996) Med. Hypoth. , vol.47 , pp. 283-288
    • Paschen, W.1
  • 33
    • 0029131752 scopus 로고
    • Comparison of in vitro ischaemia-induced disturbances in energy metabolism and protein synthesis in the hippocampus of rats and gerbils
    • Paschen, W. & B. Djuricic: Comparison of in vitro ischaemia-induced disturbances in energy metabolism and protein synthesis in the hippocampus of rats and gerbils. J. Neurochem. 1995, 65, 1692-1697.
    • (1995) J. Neurochem. , vol.65 , pp. 1692-1697
    • Paschen, W.1    Djuricic, B.2
  • 34
    • 0029813394 scopus 로고    scopus 로고
    • Depletion of neuronal endoplasmic reticulum calcium stores by thapsigargin: Effect on protein synthesis
    • Paschen, W., J. Doutheil, C. Gissel & M. Treiman: Depletion of neuronal endoplasmic reticulum calcium stores by thapsigargin: effect on protein synthesis. J. Neurochem. 1996, 67, 1735-1743.
    • (1996) J. Neurochem. , vol.67 , pp. 1735-1743
    • Paschen, W.1    Doutheil, J.2    Gissel, C.3    Treiman, M.4
  • 35
    • 0032979420 scopus 로고    scopus 로고
    • Disturbances of the functioning of endoplasmic reticulum: A key mechanism underlying neuronal cell injury?
    • Paschen, W. & J. Doutheil: Disturbances of the functioning of endoplasmic reticulum: a key mechanism underlying neuronal cell injury? J. Cereb. Blood Flow Metabol. 1999, 19, 1-18.
    • (1999) J. Cereb. Blood Flow Metabol. , vol.19 , pp. 1-18
    • Paschen, W.1    Doutheil, J.2
  • 36
    • 0028938425 scopus 로고
    • Activation of the double-stranded RNA-regulated protein kinase by depletion of endoplasmic reticulum calcium stores
    • Prostko, C. R., J. N. Dholakia, M. A. Brostrom & C. O. Brostrom: Activation of the double-stranded RNA-regulated protein kinase by depletion of endoplasmic reticulum calcium stores. J. Biol. Chem. 1995, 270, 6211-6215.
    • (1995) J. Biol. Chem. , vol.270 , pp. 6211-6215
    • Prostko, C.R.1    Dholakia, J.N.2    Brostrom, M.A.3    Brostrom, C.O.4
  • 37
    • 0019842691 scopus 로고
    • Cell damage in the brain: A speculative synthesis
    • Siesjö, B. K.: Cell damage in the brain: a speculative synthesis. J. Cereb. Blood Flow Metabol. 1981, 1, 155-185.
    • (1981) J. Cereb. Blood Flow Metabol. , vol.1 , pp. 155-185
    • Siesjö, B.K.1
  • 38
    • 0025858620 scopus 로고
    • 8-Diethylamino-octyl-3,4,5-trimethoxybenzoate, a calcium store blocker, increases calcium influx, inhibits alpha-1 adrenergic receptor calcium mobilization, and alters iodide transport in FRTL-5 rat tyroid cells
    • Smallridge, R. C., I. D. Gist & C. Ambroz: 8-Diethylamino-octyl-3,4,5-trimethoxybenzoate, a calcium store blocker, increases calcium influx, inhibits alpha-1 adrenergic receptor calcium mobilization, and alters iodide transport in FRTL-5 rat tyroid cells. Endocrinol. 1991, 129, 542-549.
    • (1991) Endocrinol. , vol.129 , pp. 542-549
    • Smallridge, R.C.1    Gist, I.D.2    Ambroz, C.3
  • 39
    • 0029067408 scopus 로고
    • Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis
    • Srivastava, S. P., M. V. Davies & R. J. Kaufman: Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis. J. Biol. Chem. 1995, 270, 16619-16624.
    • (1995) J. Biol. Chem. , vol.270 , pp. 16619-16624
    • Srivastava, S.P.1    Davies, M.V.2    Kaufman, R.J.3
  • 41
    • 0022461293 scopus 로고
    • Persistent inhibition of protein synthesis precedes delayed neuronal death in postischaemic gerbil hippocampus
    • Thilmann, R., Y. Xie, P. Kleihues & M. Kiessling: Persistent inhibition of protein synthesis precedes delayed neuronal death in postischaemic gerbil hippocampus. Acta neuropathol. (Berl.) 1986, 71, 88-93.
    • (1986) Acta Neuropathol. (Berl.) , vol.71 , pp. 88-93
    • Thilmann, R.1    Xie, Y.2    Kleihues, P.3    Kiessling, M.4


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