Lymphocytes in sural nerve biopsies from patients with plasma cell dyscrasia and polyneuropathy

Journal of the Peripheral Nervous System

Volumn 4, Issue 2, 1999, Pages 91-98

  Solders, Göran ^a   Nennesmo, Inger ^a   Ernerudh, Jan ^b   Cruz, Mabel ^a   Vrethem, Magnus ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Lymphocytes; MGUS; Nerve biopsy; Plasma cell dyscrasia; Polyneuropathies

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADULT; AGED; ARTICLE; CELL INFILTRATION; CLINICAL ARTICLE; DEMYELINATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; LYMPHOCYTE; LYMPHOMA; MALE; MONOCLONAL IMMUNOGLOBULINEMIA; MYELOMA; NERVE BIOPSY; NERVE CONDUCTION; NERVE FIBER DEGENERATION; PERTHES DISEASE; PLASMA CELL DYSCRASIA; POLYNEUROPATHY; PRIORITY JOURNAL; SURAL NERVE;

ADULT; AGED; B-LYMPHOCYTE SUBSETS; BIOPSY; ELECTROMYOGRAPHY; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LYMPHOCYTES; MALE; MIDDLE AGED; NEURAL CONDUCTION; PARAPROTEINEMIAS; PERIPHERAL NERVOUS SYSTEM DISEASES; SURAL NERVE; T-LYMPHOCYTE SUBSETS; WALDENSTROM MACROGLOBULINEMIA;

EID: 0032781720     PISSN: 10859489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Kelly JJ Jr, Kyle RA, O'Brien PC, Dyck PJ: Prevalence of monoclonal protein in peripheral neuropathy. Neurology (NY) 1981; 31:1480-1483.
2. Ösby LE, Noring L, Hast R, Kjellin KG, Knutsson E, Sidén Å: Benign monoclonal gammopathy and peripheral neuropathy. Br. J. Haematol. 1982; 51:531-539.
3. Donofrio PD, Kelly JJ Jr: Peripheral neuropathy in monoclonal gammopathy of undetermined significance. Muscle Nerve 1989; 12:1-8.
4. Braun PE, Frail DE, Latov N: Myelin-associated glycoprotein is the antigen for monoclonal IgM in polyneuropathy. J. Neurochem. 1982; 128:1261-1265.
5. Bleasel AF, Hawke SHB, Pollard JD, McLeod JG: IgG monoclonal paraproteinemia and peripheral neuropathy. J. Neurol. Neurosurg. Psychychiatry 1993; 56:52-57.
6. Simmons Z, Bromberg MB, Feldman EL, Blaivas M: Polyneuropathy associated with IgA monoclonal gammopathy of undetermined significance. Muscle Nerve 1993; 16:77-83.
7. Dalakas MC, Engel WK: Polyneuropathy with monoclonal gammopathy: Studies of 11 patients. Ann. Neurol. 1981; 10:45-52.
8. Galassi G, Nemni R: Sensory action potentials and biopsy of the sural nerve in the neuropathy of nonmalignant IgMk plasma cell dyscrasia. Eur. Neurol. 1986; 25:1-9.
9. Smith T, Sherman W, Olarte MR, Lovelace RE: Peripheral neuropathy associated with plasma cell dyscrasia: a clinical and electrophysiological follow-up study. Acta Neurol Scand. 1987; 75:244-248.
10. Kelly JJ Jr: The electrodiagnostic findings in peripheral neuropathy associated with monoclonal gammopathy. Muscle Nerve 1990; 13:1113-1117.
11. Yeung KB, Thomas PK, King RHM, Waddy H, Will RG, Hughes RAC, Gregson NA, Leibowitz S: The clinical spectrum of peripheral neuropathies associated with benign monoclonal IgM, IgG and IgA paraproteinemia. Comparative clinical, immunological and nerve biopsy findings. J. Neurol. 1991; 238:383-391.
12. Vital C, Vallat JM, Deminiere C, Loubet A, Leboutet MJ: Peripheral nerve damage during multiple myeloma and Waldenstrom's macroglobinemia. Cancer: 1982; 50:1491-1497.
13. Mendell JR, Sahenk Z, Whitaker JN, Trapp BD, Yates AJ, Griggs RC, Qarles RH: Polyneuropathy and IgM monoclonal gammopathy: Studies on the pathogenetic role of anti-myelin-associated glycoprotein antibody. Ann. Neurol. 1985; 17:243-254.
14. Melmed C, Frail D, Duncan I, Braun P, Danoff D, Finlayson M, Stewart J: Peripheral neuropathy with IgM kappa monoclonal immunoglobulin directed against myelin-associated glycoprotein. Neurology (NY) 1983;33:1397-1405.
15. Steck AJ, Murray N, Meier C, Page N, Perruisseau G: Demyelinating neuropathy and monoclonal IgM antibody to myelin-associated glycoprotein. Neurology (NY) 1983; 33:19-23.
16. Kelly JJ Jr: Peripheral neuropathies associated with monoclonal proteins: A clinical review. Muscle Nerve 1985; 8:138-150.
17. Latov N, Sherman WH, Nemni R, Galassi G, Shyong JS, Penn AS, Olarte M, Rowland LP, Osserman E: Plasma-cell dyscrasia and peripheral neuropathy with a monoclonal antibody to peripheral-nerve myelin. N. Eng. J. Med. 1980; 303:618-621.
18. Nemni R, Galassi G, Latov N, Sherman WH, Olarte MR, Hays A: Polyneuropathy in nonmalignant IgM plasma cell dyscrasia: A morphological study. Ann. Neurol. 1983; 14:43-54.
19. Smith IS, Kahn N, Lacey BW, King RHM, Eames RA, Whybrew DJ, Thomas PK: Chronic demyelinating neuropathy associated with benign IgM paraproteinemia. Brain 1983; 106:169-195.
20. Kanda T, Usui S, Beppu H, Miyamoto K, Yamawaki M, Oda M: Blood-nerve barrier in IgM paraproteinemic neuropathy: a clinicopathologic assessment. Acta Neuropathol. (Berl) 1998; 95:184-192.
21. Powell H, Rodriguez M, Hughes RAC: Microangiopathy of vasa nervorum in dysglobulinemic neuropathy. Ann. Neurol. 1984; 15:386-394.
22. Forssman O, Björkman G, Hollender A, Englund N-E: IgM-producing lymphocytes in peripheral nerve in a patient with benign monoclonal gammopathy. Scand. J. Haemat. 1973; 11:332-335.
23. Jacobs JM: Morphological changes at paranodes in IgM paraproteinaemic neuropathy. Microscopy Research &Technique 1996; 34:544-553.
24. Gabriel JM, Erne B, Bernasconi L, Tosi C, Probst A, Landmann L, Steck AJ: Confocal microscopic localization of anti-myelin-associated glycoprotein autoantibodies in a patient with peripheral neuropathy initially lacking a detectable IgM gammopathy. Acta Neuropathol (Berl) 1998; 95:540-546.
25. Wang J-F, Schröder JM: Morphometric evaluation of paraneoplastic neuropathies associated with carcinomas, lymphomas, ans dysproteinemias. J. Peripheral Nervous System 1998; 3:259-266.
26. Nobile-Orazio E, Vietovisz T, Messito M-J, Sherman WH, Latov N: Anti-MAG IgM antibodies in patients with neuropathy and IgM M proteins: Detection by ELISA. Neurology (NY) 1983; 33:939-943.
27. Freddo L, Ariga T, Saito M, Macala MC, Yu RK, Latov N: The neuropathy of plasma cell dyscrasia: Binding of IgM M-proteins to peripheral nerve glycolipids. Neurology 1985; 35:1420-1424.
28. Sherman WH, Latov N, Hays AP, Takatsu M, Nemni R, Galassi G, Osserman E: Monoclonal IgMk antibody precipitating with chondroitin sulfate from patients with axonal polyneuropathy and epidermolysis. Neurology (NY) 1983; 33:192-210.
29. Cruz M, Ernerudh J, Olsson T, Höjeberg B, Link H: Occurrence and isotype of antibodies against peripheral nerve myelin in serum from patients with peripheral neuropathy and healthy controls. J. Neurol. Neurosurg. Psychiatry 1988; 51:820-825.
30. McGinnis S, Kohriyama T, Yu R, Pesce M, Latov N: Antibodies to sulphated glucuronic acid containing glycosphingolipids in neuropathy associated with anti-MAG antibodies and in normal subjects. J. Neuroimmunol. 1988; 17:119-126.
31. Vrethem M, Skogh T, Berlin G, Holmgren H, Ernerudh J: Antibodies to peripheral nerve myelin may occur without clinical neuropathy in healthy persons. J. Neuroimmunol. 1991; 32:219-222.
32. Cruz M, Jiang Y-Y, Ernerudh J, Solders G, Olsson T, Osterman P-O, Link H: Antibodies to myelin associated glycoprotein are found in cerebrospinal fluid in polyneuropathy associated with monoclonal serum IgM. Arch. Neurol. 1991; 48:66-70.
33. Hall SM, Hughes RAC, Atkinson PF, McColl I, Gale A: Motor nerve biopsy in severe Guillain-Barre syndrome. Ann. Neurol. 1992; 31:441-444.
34. Krendel DA, Parks HP, Anthony DC, St Clair MB, Graham DG: Sural nerve biopsy in chronic inflammatory demyelinating polyradiculoneuropathy. Muscle Nerve 1989; 12:257-264.
35. Kissel JT, Riethman JL, Omerza J, Rammohan KW, Mendell JR: Peripheral nerve vasculitis: Immune characterization of the vascular lesions. Ann. Neurol. 1989; 25:291-297.
36. Croft PB, Ulrich H, Wilkinson M: Peripheral neuropathy of sensorymotor type associated with malignant disease. Brain 1967; 90:31-66.
37. Dayan AD, Lewis PD: Demyelinating neuropathy in macroglobulinemia. Neurology 1966; 16:1141-1144.
38. Dalakas M, Flaum MA, Rick M, Engel WK, Gralnick HR: Treatment of polyneuropathy in Waldenström's macroglobinemia: role of paraproteinemia and immunological studies. Neurology 1983; 33:1406-1410.
39. Julien C, Vital C, Vallat JM, Lagueny A, Ferrer X, Leboutet MJ: Chronic demyelinating neuropathy with IgM-producing lymphocytes in peripheral nerve and delayed appearance of "benign" monoclonal gammopathy. Neurology (Cleveland) 1984; 34:1387-1389.
40. Meier C, Vandevelde M, Steck A, Zubriggen A: Demyelinating polyneuropathy associated with monoclonal IgM paraproteinemia. J. Neurol. Sci. 1983; 63:353-367.
41. Meier C, Steck A, Hess C, Miloni E, Tschopp L: Polyneuropathy in Waldenström's macroglobulinemia. Reduction of endoneurial IgM-deposits after treatment with chlorambucil and plasmapheresis. Acta Neuropathol. (Berl.) 1984; 64:297-307.
42. Bosch ER, Ansbacher LE, Goeken JA, Cancilla PA: Peripheral neuropathy associated with monoclonal gammopathy. Studies of intraneural injections of monoclonal immunoglobulin sera. J. Neuropathol. Exp. Neurol. 1982; 41:446-459.
43. Steck AJ, Murray N, Justafre J-C, Meier C, Toyka KV, Heininger K, Stoll G: Passive transfer studies in demyelinating neuropathy with IgM monoclonal antibodies to myelin-associated glycoprotein. J. Neurol. Neurosurg. Psychiatry 1985; 48:927-929.
44. Hays AP, Latov N, Takatsu M, Sherman WH: Experimental demyelination of nerve induced by serum of patients with neuropathy and an anti-MAG IgM M-protein. Neurology (NY)1987; 37:242-256.
45. Willison HJ, Trapp BD, Bacher JD, Dalakas MC, Griffin JW, Quarles RH: Demyelination induced by intraneural injection of human antimyelin-associated glycoprotein antibodies. Muscle Nerve 1988; 11:1169-1176.
46. Hafler DA, Johnson DJ, Kelly JJ, Panitch H, Kyle R, Weiner HL: Monoclonal gammopathy and neuropathy: Myelin-associated glycoprotein reactivity and clinical characteristics. Neurology 1986; 36:75-78.
47. Ernerudh JH, Vrethem M, Andersen O, Lindberg C, Berlin G: Immunochemical and clinical effects of immunosuppressive treatment in monoclonal IgM neuropathy. J. Neurol. Neurosurg. Psychiatry 1992; 55:930-934.
48. Kelly JJ, Adelman LS, Berkman E, Bhan I: Polyneuropathies associated with IgM monoclonal gammopathies. Arch. Neurol. 1988; 45:1355-1359.
49. Latov N, Godfrey M, Thomas Y, Nobile-Orazio E, Spatz L, Abraham J, Perman G, Freddo L, Chess L: Neuropathy and anti-myelin associated glycoproyein IgM M-proteins: T cell regulation of M-protein secretion in vitro. Ann. Neurol. 1985; 18:182-188.
50. Vrethem M, Ernerudh J, Cruz M, Olerup O, Solders G, Ekstedt B, Andersen O, Hillert J: Susceptibility to demyelinating polyneuropathy in plasma cell dyscrasia may be influenzed by amino acid position 9 of the HLA-DRβ-chain. J. Neuroimmunol. 1993; 43:139-144.
51. Vrethem M, Ekstedt B, Skogh T, Andersen O, Lycke J, Ernerudh J: Soluble interleukin-2 receptor levels in serum of patients with demyelinating polyneuropathy associated with monoclonal gammopathy. J. Neurol. Neurosurg. Psychiatry 1993; 56:721-722.
52. Vrethem M, Dahle L, Ekerfelt C, Nilsson J, Ekstedt B, Ernerudh J: Abnormalities in T-lymphocyte populations in blood from patients with demyelinating polyneuropathy associated with monoclonal gammopathy. J. Neurol. Sci. 1994; 122:171-178.
53. Ellie E, Vital A, Steck A, Boiron J-M, Vital C, Julien J: Neuropathy associated with "benign" anti-myelin-associated glycoprotein IgM gammopathy: clinical, immunological, neurophysiological pathological findings and response to treatment in 33 cases. J. Neurol. 1996; 243:34-43.
54. Schmidt B, Toyka KV, Kiefer R, Full J, Hartung HP, Pollard J: Inflammatory infiltrates in sural nerve biopsies in Guillain-Barre syndrome and chronic inflammatory demyelinating neuropathy. Muscle Nerve 1996; 19:474-487.
55. Lanzavecchia A: Antigen uptake and accumulation in antigen-specific B cells. Immun. Rev. 1987; 99:39-51.
56. Mosmann TR, Sad S: The expanding universe of T-cell subsets: Th1, Th2 and more. Immunology Today 1996; 17:138-146.
57. Ekerfelt C, Ernerudh J, Vrethem M: Th1 like responses to peptides from peripheral nerve myelin proteins in patients with polyneuropathy associated with monoclonal gammopathy. Clin. Exp. Immunol. 1997; 108:516-522.