Introduction of Gadd153 gene into gastric cancer cells can modulate sensitivity to anticancer agents in association with apoptosis

Anticancer Research

Volumn 19, Issue 3 A, 1999, Pages 1779-1783

  Kim, Ryungsa ^a   Ohi, Yuko ^b   Inoue, Hideki ^b   Aogi, Kenjiro ^b   Toge, Tetsuya ^b  

^a HIROSHIMA UNIVERSITY   (Japan)

^b NONE

Author keywords

Anticancer agents; Apoptosis; Gadd 153; Gastric cancer cells

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DOCETAXEL; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA DEGRADATION; DNA TRANSFECTION; DRUG SENSITIVITY; GENE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STOMACH CANCER;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ATP-BINDING CASSETTE TRANSPORTERS; CCAAT-ENHANCER-BINDING PROTEINS; CISPLATIN; DNA FRAGMENTATION; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENZYME INDUCTION; ETOPOSIDE; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; PACLITAXEL; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; STOMACH NEOPLASMS; TAXOIDS; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032781423     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Kerr JFR, Winterford CM, Harmon, BV: Apoptosis: Its significance in cancer and cancer therapy. Cancer 73: 2013-2026, 1994.
2. Lowe SW, Ruley HE, Jacks T and Houseman DE: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967, 1993.
3. Lowe SW, Schmitt EM, Smith SW, Osborne BA, and Jacks T: p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847-852, 1993.
4. Zambetti GP, and Levine AJ: A comparison of the biological activities of wild-type and mutant p53. FASEB J 7: 855-865, 1993.
5. Zhan Q, Carrier F, and Fornace AJ, Jr: Induction of cellular p53 activity by DNA-damaging agents and growth arrest. Mol Cell Biol 13: 4242-4250, 1993.
6. Barone MV, Crozat A, Tabaee A, Philipson L, and Ron D: CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest. Genes Dev 8: 453-464, 1994.
7. Luethy JD, and Holbrook NJ: Activation of the gadd153 promoter by genotoxic agents; a rapid and specific response to DNA damage. Cancer Res- 52: 5-10, 1992.
8. Luethy JD, and Holbrook NJ: The pathway regulating gadd153 induction in response to DNA damage is independent of protein kinase C and tyrosine kinases. Cancer Res (SUPPL) 54: 1902s-1906s, 1994.
9. Chu G, and Chang E: Cisplatin-resistant cells express increased levels of a factor that recognizes DNA. Proc Natl Acad Sci USA 87: 3324-3327, 1990.
10. Carmichael J, DeGraff WG, Gazdar AF, Minna JD, and Mitchell JB: Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 47: 936-942, 1987.
11. Maniatis T, Fritsch E, and Sambrook J: Molecular cloning: A laboratory Mannual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
12. Fornace AJ, Jr, Nebert DW, Hollander MC, Luethy JD, Papathanasiou M, Fargnoli J, and Holbrook N: Mammanlian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Mol Cell Biol 9: 4196-4203, 1989.
13. Luethy JD, Fargnoli J, Park JS, Fornace AJ, Jr, and Holbrook NJ: Isolation and characterization of the hamster gadd153 gene. J Biol Chem 265: 16521-16526, 1990.
14. Ron D, and Habener JF: CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 6: 439-453, 1992.
15. Beatrice E, Laurence D, Michele A, and Eric S: Increased gadd153 messenger RNA level is associated with apoptosis in human leukemic cells treated with etoposide. Cancer Res 57: 686-695, 1997.
16. Park JS, Luethy JD, Wang MG, Fargnoli J, Fornace AJ, Jr, McBride OW, and Holbrook NJ: Isolation, characterization, and chromosomal localization of the human Gadd153 gene. Gene 116: 259-267, 1992.
17. Kim R and Beck WT: Differences between drug-sensitive and -resistant human leukemic CEM cells in c-jun expression, AP-1 DNA binding activity, and formation of Jun/Fos family dimers, and their association with internucleosomal DNA ladders after treatment with VM-26. Cancer Res 54: 4958-4966, 1994.
18. Catchpoole, DR, and Stewart BW: Etoposide-induced cytotoxicity in two human T-cell leukemic lines: delayed loss of membrane permeability rather than DNA fragmentation as an indicator of programmed cell death. Cancer Res 53: 4287-4296, 1993.
19. Oberhammer F, Wilson JW, Dive C, Morris I D, Hickman J, Wakeling AE, Walker PR, and Sikorska M: Apoptotic cell death in epithelial cells: cleavage of DNA to 300 and / or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 12: 3679-3684, 1993.
20. Clarke AR, Purdie CA, Harrioson DJ, Morris DG, Bird CC, Hooper ML, Wyllie AH: Thymocyte apoptosis induced by p53-dependent and -independent pathways. Nature 362: 849-852, 1993.
21. Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, and Jacks T: p53-dependent and -independent expression of p21 during cell growth, differentiation, and DNA damage. Genes & Develop 9: 935-944, 1995.
22. Hollstein M, Sidransky D, Vogelstein B, and Harris CC: p53 mutations in human cancers. Science 253: 49-53, 1991.
23. Lowe SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE, Housman DE, and Jacks T: p53 status and the efficacy of cancer therapy in vivo. Science 266: 807-810, 1994.
24. Koechli OR, Schaer GN, Seifert B, Hornung R, Haller U, Eppenberger U, and Mueller H: Mutant p53 protein associated with chemosensitivity in breast cancer specimens. Lancet 344: 1647, 1994.
25. Zhan Q, Bae I, Kastan MB, and Fornace AJ, Jr: The p53-dependent r -ray response of gadd 45. Cancer Res 54: 2755-2760, 1994.