Sperm mitochondria-associated cysteine-rich protein (SMCP) is an autoantigen in lewis rats

Biology of Reproduction

Volumn 61, Issue 2, 1999, Pages 428-435

  Herr, John C ^a   Thomas, David ^a   Bush, Leigh Ann ^a   Coonrod, Scott ^a   Khole, Vrinda ^a,b   Howards, Stuart S ^a   Flickinger, Charles J ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b Institute for Research in Reproduction India   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; AUTOANTIGEN; CELL PROTEIN; COMPLEMENTARY DNA; CYSTEINE; SELENOPROTEIN; SPERM ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; MALE; MITOCHONDRION; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN PURIFICATION; RAT; SPERMATOZOON; VASECTOMY;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; BASE SEQUENCE; BLOTTING, WESTERN; DNA, COMPLEMENTARY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCENT ANTIBODY TECHNIQUE; MALE; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PROTEINS; RABBITS; RATS; RATS, INBRED LEW; SELENOPROTEINS; SPERMATOZOA; TESTIS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0032780878     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod61.2.428     Document Type: Article

References (74)

1. Tung KSK. Autoimmunity of the testis. In: Dhindsa D, Schumacker G (eds.), Immunologic Aspects of Infertility and Fertility Regulation. New York: Elsevier-North Holland; 1980: 33-91.
2. Tung KSK, Menge AC. Sperm and testicular autoimmunity. In: Rose NR, Mackay IR (eds.), The Autoimmune Diseases. New York: Academic Press: 1985: 537-590.
3. Tung KSK, Teuscher C. Mechanisms of autoimmune disease in the testis and ovary. Hum Reprod Update 1995; 1:35-50.
4. Alexander NJ. Immunologic and morphologic effects of vasectomy in the rhesus monkey. Fed Proc 1975; 34:1692-1697.
5. Alexander NJ, Anderson DJ. Vasectomy - consequences of autoimmunity to sperm antigens. Fertil Steril 1979; 32:253-260.
6. Rose NR, Lucas PL. Immunologic consequences of vasectomy: II. Two-year summary of a prospective study. In: Lepow IH, Crozier R (eds.), Vasectomy: Immunologic and Pathophysiologic Effects in Animals and Man. New York: Academic Press; 1979: 533-573.
7. Flickinger CJ. The effects of vasectomy on the testis. N Engl J Med 1985:313:1283-1285.
8. Bedford JM. Adaptations of the male reproductive tract and the fate of spermatozoa following vasectomy in the rabbit, rhesus monkey, hamster and rat. Biol Reprod 1976; 14:118-142.
9. Tung KS. Allergic orchitis lesions are adoptively transferred from vasoligated guinea pigs to syngeneic recipients. Science 1978; 201:833-835.
10. Flickinger CJ, Herr JC, Howards SS, Caloras D, Yarbro ES, Spell DR, Gallien TN. The influence of vasovasostomy on testicular alterations after vasectomy in Lewis rats. Anat Rec 1987; 217:137-145.
11. Tung KS, Alexander NJ. Monocytic orchitis and aspermatogenesis in normal and vasectomized rhesus macaques (Macaco mulatta). Am J Pathol 1980; 101:17-30.
12. Jarow JP, Budin RE, Dym M, Zirkin BR, Noren S, Marshall FF. Quantitative pathologic changes in the human testis after vasectomy. A controlled study. N Engl J Med 1985; 313:1252-1256.
13. Flickinger CJ, Howards SS, Herr JC. Effects of vasectomy on the epididymis. Microsc Res Tech 1995; 30:82-100.
14. Linnet L, Hjort T, Fogh-Anderson P. Association between failure to impregnate after vasovasostomy and sperm agglutinins in semen. Lancet 1981; 1:117-119.
15. Parslow JM, Royle MG, Kingscott MMB, Wallace DMA, Hendry WF. The effects of sperm antibodies on fertility after vasectomy reversal. Am J Reprod Immunol 1983; 3:28-31.
16. Haas GG, Cines DB, Schreiber AD. Immunologic infertility: identification of patients with antisperm antibody. N Engl J Med 1981; 303: 722-727.
17. Mathur S, Baker ER, Williamson HO, Derrick FC, Teague KJ, Fudenberg HH. Clinical significance of sperm antibodies in infertility. Fertil Steril 1981; 36:486-495.
18. Marshburn PB, Kutteh WH. The role of antisperm antibodies in infertility. Fertil Steril 1994; 61:799-811.
19. Boyse EA, Old LJ. Some aspects of normal and abnormal cell surface genetics. Annu Rev Genet 1969; 3:269-290.
20. Setchell BP, Uksila J, Maddocks S, Pollanen P. Testis physiology relevant to immunoregulation. J Reprod Immunol 1990; 18:19-32.
21. Hoffer AP, Hinton BT. Morphological evidence for a blood-epididymis barrier and the effects of gossypol on its integrity. Biol Reprod 1984; 30:991-1004.
22. Flickinger CJ, Howards SS, Carey PO, Spell DR, Kendrick SJ, Caloras D, Gallien TN, Herr JC. Testicular alterations are linked to the presence of elevated antisperm antibodies in Sprague-Dawley rats after vasectomy and vasovasostomy. J Urol 1988; 140:627-631.
23. Chehval MJ, Martin SA, Alexander NJ, Winkelmann T. The effect of unilateral injury to the vas deferens on the contralateral testis in immature and adult rats. J Urol 1995; 153:1313-1315.
24. Pedersen J, Rubenson A, Nilsson LA. Formation of antisperm autoantibodies in rats vasectomized at prefertile age. Scand J Urol Nephrol 1983; 17:277-281.
25. Flickinger CJ, Herr JC, Baran ML, Howards SS. Temporal appearance of antisperm antibodies during sexual maturation of rats after obstruction of the vas deferens. J Androl 1995; 16:75-79.
26. Pedersen J, Rubenson A, Nilsson LA. Occurrence of sperm antibodies in adult rats after prefertile traumatic vas lesions. Scand J Urol Nephrol 1987; 21:1-4.
27. Handley HH, Flickinger CJ, Herr JC. Post-vasectomy sperm autoimmunogens in the Lewis rat. Biol Reprod 1988; 39:1239-1250.
28. Flickinger CJ, Howards SS, Bush LA, Baker LA, Herr JC. Antisperm autoantibody responses to vasectomy and vasovasostomy in Fischer and Lewis rats. J Reprod Immunol 1995; 28:137-157.
29. Flickinger CJ, Baran ML, Howards SS, Herr JC. Sperm autoantigens recognized by autoantibodies in developing rats following prepubertal obstruction of the vas deferens. J Androl 1996; 17:433-442.
30. Naaby-Hansen S, Flickinger CJ, Herr JC. Two-dimensional gel electrophoretic analysis of vectorially labeled surface proteins of human spermatozoa. Biol Reprod 1997; 56:771-787.
31. Kleene KC. The mitochondrial capsule selenoprotein - a structural protein in the mitochondrial capsule of mammalian sperm. In: Burk RF (ed.), Selenium in Biology and Human Health. New York: Springer-Verlag; 1994: 135-148.
32. Freemerman AJ, Wright RM, Flickinger CJ, Herr JC. Cloning and sequencing of baboon and cynomolgus monkey intra-acrosomal protein SP-10: homology with human SP-10 and a mouse sperm antigen (MSA-63). Mol Reprod Dev 1993; 34:140-148.
33. Freemerman AJ, Flickinger CJ, Herr JC. Characterization of alternatively spliced human SP-10 mRNAs. Mol Reprod Dev 1995: 41:100-108.
34. Sambrook J, Fritsch EF, Maniatis TE. Molecular Cloning: A Laboratory Manual. Plainview, NY: Cold Spring Harbor Laboratory Press; 1989.
35. Karimpour I, Cutler M, Shih D, Smith J, Kleene KC. Sequence of the gene encoding the mitochondrial capsule selenoprotein of mouse sperm: identification of three in-phase TGA selenocysteine codons. DNA Cell Biol 1992; 11:693-699.
36. Reddi PP, Castillo JR, Klotz K, Flickinger CJ, Herr JC. Production in Escherichia coli, purification and immunogenicity of acrosomal protein SP-10, a candidate contraceptive vaccine. Gene 1994; 147:189-195.
37. Tartof KD, Hobbs CA. Improved media for growing plasmid and cosmid clones. Bethesda Res Lab Focus 1987; 9:12.
38. Shulman M, Wilde CO, Kohler G. A better cell line for making hybridomas secreting specific antibodies. Nature 1978; 276:269-270.
39. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227:680-685.
40. Olmstead JB. Affinity purification of antibodies from diazotized paper blots of heterogeneous protein samples. J Biol Chem 1981; 256: 11955-11959.
41. Almeida EAC, Huovila A-PJ, Sutherland AE, Stephens LE. Calarco PG, Shaw LM, Mercurio AM, Sonnenberg A, Primakoff P, Myles D, White JM. Mouse egg integrin α6β1 functions as a sperm receptor. Cell 1995; 81:1095-1104.
42. Adham IM, Tessmann D, Soliman KA, Murphy D, Kremling H, Szpirer C, Engel W. Cloning, expression, and chromosomal localization of the rat mitochondrial capsule selenoprotein gene (MCS): the reading frame does not contain potential UGA selenocysteine codons. DNA Cell Biol 1996; 15:159-166.
43. Aho H, Schwemmer M, Tessmann D, Murphy D, Mattei G, Engel W, Adham IM. Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP). Genomics 1996; 32:184-190.
44. Cataldo L, Baig K, Oko R, Mastrangelo MA, Kleene KC. Developmental expression, intracellular localization, and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm. Mol Reprod Dev 1996; 45:320-331.
45. Otani H, Tanaka O, Kasai K-I, Yoshioka T. Development of mitochondrial helical sheath in the middle piece of the mouse spermatid tail: regular dispositions and synchronized changes. Anat Rec 1988; 222:26-33.
46. Pallini V, Baccetti B, Burrini AG. A peculiar cysteine-rich polypeptide related to some unusual properties of mammalian sperm mitochondria. In: Fawcett DW, Bedford JM (eds.), The Spermatozoon: Maturation, Motility, Surface Properties and Comparative Aspects. Baltimore: Urban & Schwartzenberg; 1979: 141-151.
47. Pallini V, Bacci E. Bull sperm selenium is bound to a structural protein of mitochondria. J Submicrosc Cytol 1979; 11:165-170.
48. Kleene KC, Smith J, Bozorgzadeh A, Harris M, Hahn L, Karimpour I, Gerstel J. Sequence and developmental expression of the mRNA encoding the seleno-protein of the sperm mitochondrial capsule in the mouse. Dev Biol 1990; 137:395-402.
49. Wu SH, Oldfield JE, Whanger PD. Effects of selenium, vitamin E, and antioxidants on testicular function in rats. Biol Reprod 1973; 8: 625-629.
50. Wu SH, Oldfield JE, Shull LR, Cheeke PR. Specific effect of selenium deficiency on rat sperm. Biol Reprod 1979; 20:793-798.
51. Calvin HI, Cooper GW, Wallace E. Evidence that selenium in rat sperm is associated with a cysteine-rich structural protein of the mitochondrial capsules. Gamete Res 1981; 4:139-149.
52. Calvin HI, Grosshans K, Musicant-Shikora SR, Turner SI. A developmental study of rat sperm and testis selenoproteins. J Reprod Fertil 1987; 81:1-11.
53. Berry MJ, Banu L, Chen Y, Mandel SJ, Kieffer JD, Harney JW, Larsen PR. Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3′ untranslated region. Nature 1991; 353:273-276.
54. Roveri A, Casasco A, Maiorini M, Dalan P, Calligaro A, Ursini F. Phospholipid hydroperoxide glutathione peroxidase of rat testis. Gonadotropin dependence and immunocytochemical identification. J Biol Chem 1992; 267:6142-6146.
55. Nantel F, Monaco L, Foulkes NS, Masquilier D, LeMeur M, Henriksen K, Dierich A, Parvinen M, Sassone-Corsi P. Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature 1996; 380:159-162.
56. Shih DM, Kleene KC. A study by in situ hybridization of the stage of appearance and disappearance of the transition protein 2 and the mitochondrial capsule seleno-protein mRNAs during spermatogenesis in the mouse. Mol Reprod Dev 1992; 33:222-227.
57. Kleene KC. Multiple controls over the efficiency of translation of the mRNAs encoding transition proteins, protamines, and the mitochondrial capsule selenoprotein in late spermatids in mice. Dev Biol 1993; 159:720-731.
58. Flickinger CJ, Yarbro ES, Howards SS, Herr JC, Caloras D, Gallien TN, Spell DR. The incidence of spermatic granulomas and their relation to testis weight after vasectomy and vasovasostomy in Lewis rats. J Androl 1986; 7:285-291.
59. Herr JC, Howards SS, Spell DR, Carey PO, Kendrick SJ, Gallien TN, Handley HH, Flickinger CJ. The influence of vasovasostomy on antisperm antibodies in rats. Biol Reprod 1989; 40:353-360.
60. Flickinger CJ. The fate of sperm after vasectomy in the hamster. Anat Rec 1982; 202:231-239.
61. Flickinger CJ, Herr JC, Baran ML, Howards SS. Testicular development and the formation of spermatic granulomas of the epididymis after obstruction of the vas deferens in immature rats. J Urol 1995; 154:1539-1544.
62. Hagopian A, Limjuco GA, Jackson JJ, Carlo DJ, Eylar EH. Experimental allergic aspermatogenic orchitis. IV. Chemical properties of sperm glycoproteins isolated from guinea pig testes. Biochim Biophys Acta 1976; 434:354-364.
63. O'Rand MG. Antigens of spermatozoa and their environment. In: Dhindsa D, Schumacher G (eds.), Immunological Aspects of Infertility and Fertility Regulation. New York: Elsevier-North Holland; 1980: 155-171.
64. Kong M, Richardson RT, Widgren EE, O'Rand MG. Sequence and localization of the mouse sperm autoantigenic protein, Sp17. Biol Reprod 1995; 53:579-590.
65. Lea IA, Richardson RT, Widgren EE, O'Rand MG. Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17. Biochim Biophys Acta 1996; 1307:263-266.
66. Nakamura S, Tsuji Y, Komori S, Koyama K. Identification and characterization of a sperm peptide antigen recognized by a monoclonal antisperm antibody derived from a vasectomized mouse. Biochem Biophys Res Commun 1994; 205:1503-1509.
67. Samuel T, Linnet L, Rumke P. Post-vasectomy autoimmunity to protamines in relation to the formation of granulomas and sperm agglutinating antibodies. Clin Exp Immunol 1978: 33:261-269.
68. Witkin SS, Higgins PJ, Bendich A. Inhibition of viral reverse transcriptase and human sperm DNA polymerase by anti-sperm antibodies. Clin Exp Immunol 1978; 33:244-251.
69. Naz RK, Deutsch J, Phillips TM, Menge AC, Fisch H. Sperm antibodies in vasectomized men and their effects on fertilization. Biol Reprod 1989; 41:163-173.
70. D'Cruz OJ, Haas GG, Lambert H. Heterogeneity of human sperm surface antigens identified by indirect immunoprecipitation of antisperm antibody bound to biotinylated sperm. J Immunol 1993; 151: 1062-1074.
71. Lee CY, Lum V, Wong E, Menge AC, Huang YS. Identification of human sperm antigens to antisperm antibodies. Am J Reprod Immunol 1983: 3:183-187.
72. Hald J, Naaby-Hansen S, Egense J, Hjort T, Bjerrum OJ. Autoantibodies against spermatozoal antigens detected by immunoblotting and agglutination. A longitudinal study of vasectomized males. J Reprod Immunol 1987; 10:15-26.
73. Naaby-Hansen S. The humoral autoimmune response to vasectomy described by immunoblotting from two-dimensional gels and demonstration of a human spermatozoal antigen immunochemically cross-reactive with the D2 adhesion molecule. J Reprod Immunol 1990; 17: 187-205.
74. Naaby-Hansen S, Bjerrum OJ. Auto- and iso-antigens of human spermatozoa detected by immunoblotting with human sera after SDS-PAGE. J Reprod Immunol 1985; 7:41-57.