Analysis of K-ras mutations in pancreatic tissue after fine needle aspirates

Anticancer Research

Volumn 19, Issue 4 A, 1999, Pages 2481-2483

  Pabst, Brigitte ^a,d   Arps, Sönke ^a   Binmoeller, Ken ^b   Thul, Roland ^b   Walsemann, Gieslind ^a,c   Fenner, Claus ^a   Klapdor, Rainer ^c  

^a Inst ClinPathology and Microbiol   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c ZeTDT Ctr Clin Exp Tum M   (Germany)

^d Labor Arndt and Partners   (Germany)

Author keywords

K ras; Mutations; Pancreas

Indexed keywords

RESTRICTION ENDONUCLEASE;

ASPIRATION BIOPSY; CHRONIC PANCREATITIS; CODON; CONFERENCE PAPER; CONTROLLED STUDY; DNA SEQUENCE; GENE MUTATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MOLECULAR GENETICS; ONCOGENE K RAS; PANCREAS ADENOCARCINOMA; PANCREAS CARCINOMA; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADENOCARCINOMA; BIOPSY, NEEDLE; CHRONIC DISEASE; GENES, RAS; HUMANS; PANCREAS; PANCREATIC NEOPLASMS; PANCREATITIS; POINT MUTATION; POLYMERASE CHAIN REACTION; REFERENCE VALUES; RESTRICTION MAPPING;

EID: 0032780682     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (10)

1. Boring C, Squires TS, Taong T: Cancer statistics. CA Cancer J Clin 43: 7-26, 1993.
2. Mooswa AR: Tumors of the pancreas. In: Comprehensive textbook of oncology (Mooswa AR, Schimpf SC, Robson MC, eds.). Vol 1 2nd ed.1991, pp 958-988.
3. Fukushige S, Waldman FM, Kimura M, Abe T, Furukawa T, Sunamura M, Kobari M, Horii A: Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma. Genes Chrom Cancer 19: 161-169, 1997.
4. Barbacid M: ras genes. Ann Rev Biochem 56: 779-827, 1987.
5. Kahn SM, Jiang W, Culbertson TA, Weinstein IB, Wiliams GM, Tomita N, Ronai Z: Rapid and sensitive nonradioactive detection of mutant K-ras genes via enriched PCR amplification. Oncogene 6: 1079-1083, 1991.
6. Uehara H, Nakaizumi A, Baba M, Iishi H, Tatsuta M, Kitamura T, Ohigashi H, Ishikawa O, Takenaka A, Ishiguro S: Diagnosis of pancreatic cancer by K-ras point mutation and cytology of pancreatic juice. Am J Gastrenterol 91: 1616-1621, 1996.
7. Tada M, Omata M, Kawai S et al: Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma. Cancer Res 53: 2472-2474, 1993.
8. Tada M, Ohashi M, Shiratori Y, Okudaira T, Komatsu Y, Kawabe T, Yoshida H, Machinami R, Kishi K, Omata M: Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology 110: 227-231, 1996.
9. Watanabe H, Sawabu N, Songur Y, Yamaguchi Y, Yamakawa O, Satomura Y, Ohta H, Motoo Y, Okai T: Detection of K-ras point mutations at codon 12 in pure pancreatic juice for the diagnosis of pancreatic cancer by PCR-RFLP analysis. Pancreas 12: 18-24, 1996.
10. Hsiang D, Friess H, Buchler M, Ebert M, Butler J, Korc M: Absence of K-ras mutations in pancreatic parenchyma of patients with chronic pancreatitis. Am J Surgery 174: 242-246, 1997.