Synthesis of fully protected nucleoside-folic acid conjugated phosphoramidites and their incorporation into antisense oligonuleotides

Nucleosides and Nucleotides

Volumn 18, Issue 6-7, 1999, Pages 1471-1472

  Bhat, Balkrishen ^a   Balow, Guity ^a   Guzaev, Andrei ^a   Cook, P Dan ^a   Manoharan, Muthiah ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; FOLIC ACID; NUCLEOSIDE; PHOSPHORAMIDIC ACID DERIVATIVE;

CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFERENCE PAPER; CONJUGATION; MOLECULAR DYNAMICS; STEREOCHEMISTRY; SYNTHESIS;

EID: 0032780655     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319908044756     Document Type: Conference Paper

References (4)

1. S.T. Crooke, B. Lebleu, Eds. (1993) Antisense Research and Applications. CRC Press, Boca Raton, FL, and references cited therein.
2. C.P. Leamon and P.S. Low, Proc. Natl. Acad. Sci., U.S.A. 1991, 88, 5572.
3. J. G. Harrison and S. Balasubramanium, Bioorg. Med. Chem. Let., 1997, ,7 1041.
4. I. Habus, J. Xie, R. P. Iyer, W-Q. Zhou, L. X. Shen and S. Agarwal, Bioconjugate Chem., 1998, 9, 283.