Short term significance of DNA ploidy and cell proliferation in breast carcinoma: A multivariate analysis of prognostic markers in a series of 308 patients

Journal of Clinical Pathology

Volumn 52, Issue 8, 1999, Pages 604-611

  Pinto, António E ^a   André, Saudade ^a   Soares, Jorge ^a  

^a INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

Author keywords

Breast carcinoma; DNA ploidy; Flow cytometry; Prognosis; S phase fraction

Indexed keywords

DNA; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; TAMOXIFEN;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER SIZE; CANCER SURVIVAL; CELL PROLIFERATION; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MULTIMODALITY CANCER THERAPY; MULTIVARIATE ANALYSIS; PLOIDY; PRIORITY JOURNAL; PROGNOSIS;

EID: 0032780189     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.52.8.604     Document Type: Article

References (54)

1. McGuire WL, Clark GM. Prognostic factors and treatment decisions in axillary node-negative breast cancer. N Engl J Med 1992;326:1756-61.
2. Gasparini G, Pozza F, Harris AL. Evaluating the potential usefulness of new prognostic and predictive indicators in node-negative breast cancer patients. J Natl Cancer Inst 1993;85:1206-19.
3. Mansour EG, Ravdin PM, Dressler L. Prognostic factors in early breast carcinoma. Cancer 1994;74:381-400.
4. Kallioniemi OP, Blanco G, Alavaikko M, et al. Tumour DNA ploidy as an independent prognostic factor in breast cancer. Br J Cancer 1987;56:637-42.
5. Cornelisse CJ, van de Velde CJ, Caspers RJ, et al. DNA ploidy and survival in breast cancer patients. Cytometry 1987;8:225-34.
6. Kallioniemi O, Blanco G, Alavaikko M, et al. Improving the prognostic value of DNA flow cytometry in breast cancer by combining DNA index and S-phase fraction. A proposed classification of DNA histograms in breast cancer. Cancer 1988;62:2183-90.
7. Clark GM, Dressler LG, Owens MA, et al. Prediction of relapse or survival in patients with node-negative breast cancer by DNA flow cytometry. Engl J Med 1989;320: 627-33.
8. Lewis WE. Prognostic significance of flow cytometric DNA analysis in node-negative breast cancer patients. Cancer 1990;65:2315-20.
9. Beerman H, Kluin PM, Hermans J, et al. Prognostic significance of DNA-ploidy in a series of 690 primary breast cancer patients. Int J Cancer 1990;45:34-9.
10. Camplejohn RS, Ash CM, Gillett CE, et al. The prognostic significance of DNA flow cytometry in breast cancer: results from 881 patients treated in a single centre. Br J Cancer 1995;71:140-5.
11. Sigurdsson H, Baldetorp B, Borg Ä, et al. Indicators of prognosis in node-negative breast cancer. N Engl J Med 1990;322:1015-53.
12. Clark GM, Mathieu M-C, Owens MA, et al. Prognostic significance of S-phase fraction in good-risk, node-negative breast cancer patients. J Clin Oncol 1992;10:428-32.
13. Joensuu H, Alanen K, Falkmer UG, et al. Effect of DNA ploidy classification on prognosis in breast cancer. Int J Cancer 1992;52:701-6.
14. Stål O, Dufmats M, Hatschek T, et al. S-phase fraction is a prognostic factor in stage I breast carcinoma. J Clin Oncol 1993;11:1717-22.
15. Witzig TE, Ingle JN, Cha SS, et al. DNA ploidy and the percentage of cells in S-phase as prognostic factors for women with lymph node negative breast cancer. Cancer 1994;74:1752-61.
16. Remvikos Y, Mosseri V, Asselain B, et al. S-phase fractions of breast cancer predict overall and post-relapse survival. Eur J Cancer 1997;33:581-6.
17. Peiró G, Lerma E, Climent MA, et al. Prognostic value of S-phase fraction in lymph node-negative breast cancer by image and flow cytometric analysis. Mod Pathol 1997;10: 216-22.
18. Muss HB, Kute TE, Case LD, et al. The relation of flow cytometry to clinical and biologic characteristics in women with node negative primary breast cancer. Cancer 1989;64: 1894-900.
19. Keyhani-Rofagha S, O'Toole RV, Farrar WB, et al. Is DNA ploidy an independent prognostic indicator in infiltrative node-negative breast adenocarcinoma? Cancer 1990;65: 1577-82.
20. Stanton PD, Cooke TG, Oakes SJ, et al. Lack of prognostic significance of DNA ploidy and S-phase fraction in breast cancer. Br J Cancer 1992;66:925-9.
21. Bosari S, Lee AKC, Tahan SR, et al. DNA flow cytometric analysis and prognosis of axillary lymph node-negative breast carcinoma. Cancer 1992;70:1943-50.
22. Baldetorp B, Bendahl P-O, Fernö M, et al. Reproducibility in DNA flow cytometric analysis of breast cancer: comparison of 12 laboratories' results for 67 sample homogenates. Cytometry (Commun Clin Cytometry) 1995; 22:115-27.
23. Schvimer M, Lash RH, Katzin WE. Intratumoral heterogeneity of DNA ploidy in breast carcinomas: a flow cytometric assessment of sampling techniques. Cytometry (Commun Clin Cytometry) 1995;22:292-6.
24. Bergers E, van Diest PJ, Baak JPA. Tumour heterogeneity of DNA cell cycle variables in breast cancer measured by flow cytometry. J Clin Pathol 1996;49:931-7.
25. Hedley DW, Clark GM, Cornelisse CJ, et al. Consensus review of the clinical utility of DNA cytometry in carcinoma of the breast. Cytometry 1993;14:482-5.
26. Beahrs OH, Henson DE, Hutter RVP, et al. Manual for staging of cancer, 5th ed. Philadelphia: JB Lippincott, 1997:171-80.
27. Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991;19:403-10.
28. Hsu SM, Raine L, Fanger H. The use of antiavidin antibody and avidin biotin peroxidase complex in immunoperoxidase technics. Am J Clin Pathol 1981;75:816-21.
29. Norton AJ, Jordan S, Yeomans P. Brief, high-temperature heat denaturation (pressure cooking): a simple and effective method of antigen retrieval for routinely processed tissues. J Pathol 1994;173:371-9.
30. Deitch AD, Law H, White RD. A stable propidium iodide staining procedure for flow cytometry. J Histochem Cytochem 1982;30:967-72.
31. Vindeløv LL, Christensson IJ, Nissen NI. Standardization of high-resolution flow cytometric DNA analyses by simultaneous use of chicken and trout red blood cells as internal reference standards. Cytometry 1983;3:328-31.
32. Dean PN, Jett JH. Mathematical analysis of DNA distributions derived from flow microfluorometry. J Cell Biol 1974; 60:523-7.
33. Bergers E, Montironi R, van Diest PJ, et al. Interlaboratory reproducibility of semiautomated cell cycle analysis of flow cytometric DNA-histograms obtained from fresh material of 1,295 breast cancer cases. Hum Pathol 1996;27:553-60.
34. Shankey TV, Rabinovitch PS, Bagwell B, et al. Guidelines for implementation of clinical DNA cytometry. Cytometry 1993;14:472-7.
35. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
36. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966;50:163-70.
37. Cox DR. Regression models and life tables. J R Stat Soc B 1972;34:187-220.
38. 0) breast carcinoma. Ann Surg 1981;193:15-25.
39. Carter CL, Allen C, Henson DE. Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases. Cancer 1989;63:181-7.
40. Uyterlinde AM, Baak JPA, Schipper NW, et al. Further evaluation of the prognostic value of morphometric and flow cytometric parameters in breast-cancer patients with long follow-up. Int J Cancer 1990;45:1-7.
41. Bergers E, Baak JPA, van Diest PJ, et al. Prognostic value of DNA ploidy using flow cytometry in 1301 breast cancer patients: results of the prospective multicenter morphometric mammary carcinoma project. Mod Pathol 1997;10:762-8.
42. O'Reilly SM, Richards MA. Is DNA flow cytometry a useful investigation in breast cancer? Eur J Cancer 1992;28: 504-7.
43. Pinto AE, André S, Nogueira M, et al. Flow cytometric DNA hypertetraploidy is associated with unfavourable prognostic features in breast cancer. J Clin Pathol 1997;50: 591-5.
44. Silvestrini R, Daidone MG, Del Bino G, et al. Prognostic significance of proliferative activity and ploidy in node-negative breast cancers. Ann Oncol 1993;4:213-19.
45. Remvikos Y, Beuzeboc P, Zajdela A, et al. Correlation of pretreatment proliferative activity of breast cancer with the response to cytotoxic chemotherapy. J Natl Cancer Inst 1989;81:1383-7.
46. Dressler LG, Seamer LC, Owens MA, et al. DNA flow cytometry and prognostic factors in 1331 frozen breast cancer specimens. Cancer 1988;61:420-7.
47. Frierson HE. Grade and flow cytometric analysis of ploidy for infiltrating ductal carcinomas. Hum Pathol 1993;24:24-9.
48. Hupperets PS, Volovics L, Schouten HC, et al. The prognostic significance of steroid receptor activity in tumor tissues of patients with primary breast cancer. Am J Clin Oncol 1997;20:546-51.
49. Thorpe SM. Estrogen and progesterone receptor determinations in breast cancer: technology, biology and clinical significance. Acta Oncol 1988;27:1-19.
50. Neville AM, Bettelheim R, Gelber RD, et al, for the International (Ludwig) Breast Cancer Study Group. Factors predicting treatment responsiveness and prognosis in node-negative breast cancer. J Clin Oncol 1992;10:696-705.
51. Host H, Lund E. Age as a prognostic factor in breast cancer. Cancer 1986;57:2217-21.
52. Nixon AJ, Neuberg D, Hayes DF, et al. Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer. J Clin Oncol 1994;12:888-94.
53. Page DL. Prognosis and breast cancer: recognition of lethal and favorable prognostic types. Am J Surg Pathol 1991;15: 334-49.
54. Sigurdsson H, Baldetorp B, Borg Å, et al. Flow cytometry in primary breast cancer: improving the prognostic value of the fraction of cells in the S-phase by optimal categorization of cut-off levels. Br J Cancer 1990;62:786-90.