Aethiopinone, an antibacterial and cytotoxic agent from Salvia aethiopis roots

Pharmaceutical Biology

Volumn 37, Issue 1, 1999, Pages 17-21

  Hernandez Perez M ^a   Rabanal, R M ^a   Arias, A ^a   De La Torre, M C ^b   Rodriguez B ^b  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

^b INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

Author keywords

Aethiopinone; Antimicrobial and cytotoxic activities; Diterpenoid quinones; Roots; Salvia aethiopis

Indexed keywords

AETHIOPINONE; ANTIINFECTIVE AGENT; CYTOTOXIC AGENT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BIOASSAY; BORDETELLA BRONCHISEPTICA; CARCINOMA CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; FRACTIONATION; HUMAN; HUMAN CELL; MICROCOCCUS LUTEUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS EPIDERMIDIS;

BACILLUS SUBTILIS; BORDETELLA BRONCHISEPTICA; MICROCOCCUS LUTEUS; SALVIA AETHIOPIS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS EPIDERMIS;

EID: 0032779887     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1076/phbi.37.1.17.6321     Document Type: Article

References (22)

1. Bauer SW, Kirby WM, Sherris JC, Thurck M (1966): Antibiotic susceptibility testing by a standarized single disc method. Am J Pathol 45: 493-496.
2. Boya MT, Valverde S (1981): An orthoquinone isolated from Salvia aethiopis. Phytochemistry 20: 1367-1368.
3. Díaz RM, García-Granados A, Moreno E, Parra A, Quevedo-Sarmiento J et al. (1988): Studies on the relationship of structure to antimicrobial properties on diterpenoid compounds from Sideritis. Planta Med 54: 301-304.
4. Duke JA (1985): Handbook of Medicinal Plants. Boca Raton, FL, CRCPress, Inc.
5. Ginda H, Kusumi T, Ishitsuka MO, Kakisawa H et al. (1988): Salviolone, a cytotoxic bisnorditerpene with abenzotropolone chromophore from a Chinese drug Dan-Shen (Salvia miltiorrhiza). Tetrahedron Lett 29: 4603-4606.
6. Grieve M (1971): A Modem Herbal New York, Dover.
7. Hernández-Pérez M, López-García RE, Rabanal RM, Darias V, Arias A (1994a): Antimicrobial activity of Visnea mocanera leaf extracts. J Ethnopharmacol 41: 115-119.
8. Hernández-Pérez. M, Sánchez-Mateo CC, Darias V, Rabanal RM(1994b): Pharmacological properties of Visnea mocanera L.f. extracts: Screening for analgesic, antipyretic, antiinflammatory, ulcerogenic activities in rodents. Phytother Res 8: 465-469.
9. Hernández-Pérez M, Sánchez-Matco CC, Darias V, Rabanal RM (1995): Behavioural effects of Visnea mocanera extract: Psychostimulant, anxiogenic properties, Phytother Res 9: 299-305.
10. Honda G, Koezuka Y, Tabata M (1988): Isolation of anti-dermatophytic substance from the root of Salvia miltiorrhiza. Chem Pharm Bull 36: 408-411.
11. Husoy T, Syversen T, Jenssen J (1993): Comparison of 4 in vitro cytoloxic tests - the MTT assay, NR assay, uridine incorporation, protein measurements. Toxicol Vitro 7: 149-154.
12. Jones R, Barry A, Garan T, Washington J (1987): In: Lennette E, Balows J, Hanser W, Shadomi J, eds., Manual de Microbiología Clinica, pp. 1206-1212. Buenos Aires, Médica Panamericana.
13. Lee AR, Wu WL, Chang WL, Lin HCCh, King ML (1987): Isolation and bioactivity of new tanshinones. J Nat Prod 50: 157-160.
14. Lin LZ, Wang XM, Huang XL, Huang Y, Tang BJ (1988): Diterpenoids from Salvia prionitis. Planta Med 54: 443-445.
15. López-García RE, Rabanal R, Darias V, Martín-Herrera D et al.(1991): A preliminary study of Cedronella canariensis (L.) var. canariensis extracts for antiinflammatory, analgesic activity in rats, mice. Phytother Rex 5: 273-275.
16. López-García RE, Hernández-Pérez M, Rabanal RM, Darias V et al., 1992): Essential oils, antimicrobial activity of two varities of Cedronella canariensis (L.) W, et B. J Ethmopharmacol 36: 207-211.
17. McLaughlin JL (1988): Brine shrimp, crown gall tumors: simple bioassays for the discovery of plant antitumor agents. Proceedings of NIH Workshop, Bioassays for Discovery of Antitumoral, Antiviral Agents from Natural Sources, Bethesda, Oct. 18-19, p. 22.
18. Meyer BN, Ferrigni NR, Putnam JE, Jacobsen LB et al. (1982): Brine shrimp: a convenient general bioassay for active plant constituents. Planta Med 45: 31-34.
19. Morion JF (1981): Atlas of Medicinal Plants of Middle America. Springfield, IL, Charles C Thomas.
20. Rodríguez B, Fernández-Gadea F, Savona G (1984): A rearranged abietane diterpenoid from the root of Salvia aethiopis. Phytochemistry 23: 1805-1806.
21. San Feliciano A, Gordaliza M, Salinero MA, Miguel del Corral JM (1993): Abietane acids: Sources, biological activities, and therapeutic uses. Planta Med 59; 485-490.
22. Tallarida RJ, Murray RB (1986): Manual of Pharmacological Calculation with Computer Programs. New York, Springer Verlag Inc.