Generation of spectrin breakdown products in peripheral nerves by addition of m-calpain

Muscle and Nerve

Volumn 22, Issue 7, 1999, Pages 905-909

  Castejon, Maria Susana ^a   Culver, Deborah G ^a   Glass, Jonathan D ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axon; Calpain; Neurofilament; Peripheral nervous system (PNS); Spectrin breakdown products

Indexed keywords

CALPAIN; CALPASTATIN; SPECTRIN;

ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; IN VITRO STUDY; NERVE DEGENERATION; NONHUMAN; PATHOPHYSIOLOGY; PERIPHERAL NERVE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DETERMINATION; RAT; SCIATIC NERVE;

ANIMALS; AXONS; BRAIN; CALCIUM; CALPAIN; HUMANS; ISOENZYMES; NERVE DEGENERATION; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SCIATIC NERVE; SPECTRIN;

EID: 0032778406     PISSN: 0148639X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4598(199907)22:7<905::AID-MUS14>3.0.CO;2-W     Document Type: Article

References (21)

1. Croall DE, DeMartino GN. Calcium-activated neutral protease (calpain) system: structure, function, and regulation. Physiol Rev 1991;71:813-847.
2. Croall DE, Slaughter CA, Wortham HS, Skelly CM, DeOgny L, Moomaw CR. Polyclonal antisera specific for the proenzyme form of each calpain. Biochim Biophys Acta 1992;1121:47-53.
3. George EB, Glass JD, Griffin JW. Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels. J Neurosci 1995;15:6445-6452.
4. Glass JD, Nash N, Dry I, Culver D, Levey AI, Wesselingh S. Cloning of m-calpain 80 kDa subunit from the axonal degeneration-resistant WLD(S) mouse mutant. J Neurosci Res 1998; 52:653-660.
5. Glass JD, Schryer BL, Griffin JW. Calcium-mediated degeneration of the axonal cytoskeleton in the Ola mouse. J Neurochem 1994;62:2472-2475.
6. Graham-Siegenthaler K, Gauthier S, Davies PL, Elce JS. Active recombinant rat calpain. II. Bacterially produced large and small subunits associated both in vivo and in vitro. J Biol Chem 1994;269:30457-30460.
7. Hamakubo T, Kannagi R, Murachi T, Matus A. Distribution of calpains I and II in rat brain. J Neurosci 1986;6:3103-3111.
8. Johnson GV, Guttmann RP. Calpains: intact and active? Bioessays 1997;19:1011-1018.
9. Levine J, Willard M. Fodrin: axonally transported polypeptides associated with the internal periphery of many cells. J Cell Biol 1981;90:631-642.
10. Rami A, Krieglstein J. Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo. Brain Res 1993;609:67-70.
11. Roberts-Lewis JM, Savage MJ, Marcy VR, Pinsker LR, Siman R. Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain. J Neurosci 1994;14:3934-3944.
12. Roots BI. Neurofilament accumulation induced in synapses by leupeptin. Science 1983;221:971-972.
13. Saatman KE, Bozyczko-Coyne D, Marcy V, Siman R, McIntosh TK. Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat. J Neuropathol Exp Neurol 1996;55:850-860.
14. Saatman KE, Murai H, Bartus RT, Smith DH, Hayward NJ, Perri BR, McIntosh TK. Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat. Proc Natl Acad Sci USA 1996;93:3428-3433.
15. Saito K, Elce JS, Hamos JE, Nixon RA. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proc Natl Acad Sci USA 1993;90:2628-2632.
16. Schlaepfer WW. Experimental alterations of neurofilaments and neurotubules by calcium and other ions. Exp Cell Res 1971;67:73-80.
17. Schlaepfer WW, Lee C, Lee VM-Y, Zimmerman U-JP. An immunoblot study of neurofilament degradation in situ and during calcium-activated proteolysis. J Neurochem 1985;44: 502-509.
18. Schlaepfer WW, Zimmerman UP. Calcium-activated protease and the regulation of the axonal cytoskeleton. In: Elam JS, Cancalon P, editors. Axonal transport in neuronal growth and regeneration. New York: Plenum Press; 1984. p 261-273.
19. Siman R, Noszek JC. Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo. Neuron 1988;1:279-287.
20. Siman R, Noszek JC, Kegerise C. Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage. J Neurosci 1989;9:1579-1590.
21. Springer JE, Azbill RD, Kennedy SE, George J, Geddes JW. Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: attenuation with riluzole pretreatment. J Neurochem 1997;69:1592-600.