A nonisotopic enzyme-based immunoassay for assessing human exposure to genistein

Nutrition and Cancer

Volumn 35, Issue 1, 1999, Pages 96-103

  Kohen, Fortune ^a   Gayer, Batya ^a   Amir Zaltsman, Yehudith ^a   Ben Hur, Herzl ^a   Thomas, Emily ^b   Lu, Lee Jane W ^b  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENISTEIN; HORSERADISH PEROXIDASE; IMMUNOGLOBULIN G; ISOFLAVONE; MONOCLONAL ANTIBODY;

ARTICLE; BINDING SITE; COLORIMETRY; DIET; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; PLASMA; SOYBEAN; URINE;

EID: 0032778183     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/S1532791496-103     Document Type: Article

References (34)

1. Mills, PK, Beeson, WL, Abbey, DE, Fraser, GE, and Phillips, RL: Dietary habits and past medical history as related to fatal pancreas cancer risk among Adventists. Cancer 61, 2578-2585, 1988.
2. Severson, RK, Nomura, AMY, Grove, JS, and Stemmermann, GN: A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii. Cancer Res 49, 1857-1860, 1989.
3. Lee, HP, Gourley, L, Duffy, SW, Esteve, J, Lee, J, et al.: Dietary effects on breast cancer risk in Singapore. Lancet 337, 1197-2000, 1991.
4. Lee, HP, Gourley, L, Duffy, SW, Esteve, J, Lee, J, et al.: Risk factors for breast cancer by age and menopausal status: a case-control study in Singapore. Cancer Causes Control 3, 313-322, 1992.
5. Steinmetz, KA, and Potter, JD: Food-group consumption and colon cancer in the Adelaide case-control study. I. Vegetables and fruit. Int J Cancer 53, 711-719, 1993.
6. Messina, MJ, Persky, V, Setchell, KDR, and Barnes, S: Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr Cancer 21, 113-131, 1994.
7. Akiyama, T, Ishida, J, Nakagawa, S, Ogawara, H, Watanabe, S, et al.: Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262, 5592-5595, 1987.
8. Conslantinou, A, Kiguchi, K, and Huberman, E: Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein. Cancer Res 50, 2618-2624, 1990.
9. Constantinou, AI, Mehta, RG, and Vaughan, A: Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones. Anticancer Res 16, 3293-3298, 1996.
10. Rao, CV, Wang, CX, Simi, B, Lubet, R, Kelloff, G, et al.: Enhancement of experimental colon cancer by genistein. Cancer Res 57, 3717-3722, 1997.
11. Murphy, PA: Separation of genistein, daidzin and their aglucones, and coumestrol by gradient high-performance liquid chromatography. J Chromatogr 211, 166-169, 1981.
12. Setchell, KD, and Welsh, MB: High-performance liquid chromatographic analysis of phytoestrogens in soy protein preparations with ultraviolet, electrochemical and thermospray mass spectrometric detection. J Chromatogr 386, 315-323, 1987.
13. Adlercreutz, H, Fotsis, T, Bannwart, C, Waehaelae, K, Brunow, G, et al.: Isotope dilution gas chromatographic-mass spectrometric method for the determination of lignans and isoflavonoids in human urine, including identification of genistein. Clin Chim Acta 199, 263-278, 1991.
14. Lu, LJW, Broemeling, LD, Marshall, MV, and Sadagopa Ramanujam, VM: A simplified method to quantify isoflavones in commercial soybean diets and human urine after legume consumption. Cancer Epidemiol Biomarkers Prev 4, 497-503, 1995.
15. Coward, L, Kirk, M, Albin, N, and Barnes, S: Analysis of plasma isoflavones by reversed-phase HPLC-multiple reaction ion monitoring-mass spectrometry. Clin Chim Acta 247, 121-142, 1996.
16. Bauminger, S, Lindner, HR, Perel, E, and Arnon, R: Antibodies to a phytoestrogen: antigenicity of genistein coupled to a synthetic polypeptide. J Endocrinol 44, 567-578, 1969.
17. Cox, RI, Wong, MS, Braden, AW, Trikojus, VM, and Lindner, HR: The formation and specificity of antibodies to phyto-oestrogens in the sheep. J Reprod Fertil 28, 157-158, 1972.
18. Wang, W: Radioimmunoassay determination of formononetin in murine plasma and mammary glandular tissue. Proc Soc Exp Biol Med 217, 281-287, 1998.
19. Lapcik, O, Hampl, R, Almaharik, N, Salakka, A, Wahala, K, et al.: Isoflavonoids, daidzein, radioimmunoassay, and metabolism. A novel radioimmunoassay for daidzein. Steroids 62, 315-320, 1997
20. Lapcik, O, Hampl, R, Hill, M, Wahala, K, Almaharik, N, et al.: Radioimmunoassay of free genistein in human serum. J Steroid Biochem Mol Biol 64, 261-268, 1998.
21. Kohen, F, Lichter, S, Gayer, B, Deboever, J, and Lu, LJW: The measurement of the isoflavone daidzein by time resolved fluorescent immunoassay - a method for assessment of dietary soya exposure. J Steroid Biochem Mol Biol 64, 217-222, 1998.
22. Kohler, G, and Milstein, C: Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion. Eur J Immunol 6, 511-519, 1976.
23. Barnard, G, Osher, J, Lichter, S, Gayer, B, DeBoever, J, et al.: The measurement of progesterone in serum by a non-competitive idiometric assay. Steroids 60, 824-829, 1995.
24. Barnard, G, and Kohen, F: Idiometric assay: a noncompetitive immunoassay for small molecules typified by the measurement of estradiol in serum. Clin Chem 36, 1945-1950, 1990.
25. Kohen, F, and Lichter, S: Monoclonal antibodies to steroid hormones. In Monoclonal Antibodies: Basic Principles, Experimental and Clinical Applications in Endocrinology, G Forti, MB Lipsett, and M Serio (eds). New York: Raven, 1986, pp 87-95.
26. Lu, LJW, and Lin, SN: A gas chromatographic-mass spectrometric method for the detection of low levels of soya-derived isoflavones, daidzein and genistein, in human plasma and urine. Proc Am Soc Mass Spect 42, 369-370, 1994.
27. Lu, LJW, Grady, JJ, Marshall, MV, Sadagopa Ramanujam, VM, and Anderson, KE: Altered time course of urinary daidzein and genistein excretion during chronic soya diet in healthy male subjects. Nutr Cancer 24, 311-323, 1995.
28. Konig, WA, Krauss, C, and Zahner, H: Stoffwechselprodukte von Mikroorganismen 6-Chlorgenistein and 6,3′-Dichlorgenistein. Helv Chim Acta 60, 2071-2078, 1977.
29. Shutt, DA, Weston, RH, and Hogan, JP: Quantitative aspects of phytooestrogen metabolism in sheep fed on subterranean clover (Trifolium subterraneum cultivar clare) or red clover (Trifolium pratense). Aust J Agric Res 21, 713-722, 1970.
30. Lu, LJW, and Anderson, KE: Short half-lives and sex differences of excretion of soya isoflavones in humans. Am J Clin Nutr 68 Suppl, 1500S-1504S, 1998.
31. Lu, LJW, Lin, SN, Grady, JJ, Nagamani, M, and Anderson, KE: Altered kinetics and extent of urinary daidzein and genistein excretion in women during chronic soya exposure. Nutr Cancer 26, 289-302, 1996.
32. Adlercreutz, H: Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chromatography-mass spectrometry. Scand J Clin Lab Invest 53, 5-18, 1993.
33. Mazur, WM, Duke, JA, Wahala, K, Rasku, S, and Adlercreutz, H: Isoflavonoids and lignans in legumes - nutritional and health aspects in humans. J Nutr Biochem 9, 193-200, 1998.
34. Xu, X, Wang, HJ, Murphy, PA, Cook, L, and Hendrich, S: Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J Nutr 124, 825-832, 1994.