Distribution of equilibrative, nitrobenzylthioinosine-sensitive nucleoside transporters (ENT1) in brain

Journal of Neurochemistry

Volumn 73, Issue 2, 1999, Pages 867-873

  Anderson, Christopher M ^a,d,e   Xiong, Wei ^a   Geiger, Jonathan D ^a   Young, James D ^b   Cass, Carol E ^b   Baldwin, Stephen A ^c   Parkinson, Fiona E ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Adenosine; Adenosine transport; ENT1; Es nucleoside transport; In situ hybridization; Nitrobenzylthioinosine; Nucleoside transport; RT PCR

Indexed keywords

ADENOSINE; CARRIER PROTEIN; NITROBENZYLTHIOINOSINE; NUCLEOSIDE TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELLULAR DISTRIBUTION; GENE ISOLATION; HUMAN; HUMAN CELL; NEUROMODULATION; NONHUMAN; NUCLEOSIDE TRANSPORT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT;

ADENOSINE; AFFINITY LABELS; ANIMALS; AUTORADIOGRAPHY; BLOTTING, NORTHERN; BRAIN CHEMISTRY; CARRIER PROTEINS; DNA PROBES; DNA, COMPLEMENTARY; EQUILIBRATIVE NUCLEOSIDE TRANSPORT PROTEINS; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; HUMANS; IN SITU HYBRIDIZATION; MALE; MEMBRANE PROTEINS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SULFUR RADIOISOTOPES; THIOINOSINE; TRITIUM;

ANIMALIA;

EID: 0032777908     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0730867.x     Document Type: Article

References (37)

1. Anderson C. M., Sitar D. S., and Parkinson F. E. (1996a) Ability of nitrobenzylthioinosine to cross the blood-brain barrier in rats. Neurosci. Lett. 219, 191-194.
2. Anderson C. M., Xiong W., Young J. D., Cass C. E., and Parkinson F. E. (1996b) Demonstration of the existence of mRNAs encoding N1/cif and N2/cit sodium/nucleoside cotransporters in rat brain. Mol. Brain Res. 42, 358-361.
3. 3H]nitrobenzylthioinosine. J. Neurosci. 5, 544-550.
4. Cass C. E. (1995) Nucleoside transport, in Drug Transport in Antimicrobial and Anticancer Chemotherapy (Georgopapadakou N. H., ed), pp. 403-450. Marcel Dekker, New York.
5. Crawford C. R., Patel D. H., Naeve C., and Belt J. A. (1998) Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line. J. Biol. Chem. 273, 5288-5293.
6. Dar M. S. (1997) Mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination: possible involvement of cAMP. Brain Res. 749, 263-274.
7. de Mendonça A. and Ribeiro J. A. (1994) Endogenous adenosine modulates long-term potentiation in the hippocampus. Neuroscience 62, 358-390.
8. de Mendonça A. and Ribeiro J. A. (1997) Adenosine and neuronal plasticity. Life Sci. 60, 245-251.
9. Fastbom J. and Fredholm B. B. (1990) Regional differences in the effect of guanine nucleotides on agonist and antagonist binding to adenosine A1-receptors in rat brain, as revealed by autoradiography. Neuroscience 34, 759-769.
10. Ferré S., Fredholm B. B., Morelli M., Popoli P., and Fuxe K. (1997) Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci. 20, 482-487.
11. 3H]nitrobenzylthioinosine in rat brain: an autoradiographic and membrane binding study. Brain Res. Bull. 13, 657-666.
12. Gidday J. M., Kim Y. B., Shah A. R., Gonzales E. R., and Park T. S. (1996) Adenosine transport inhibition ameliorates postischemic hypoperfusion in pigs. Brain Res. 734, 261-268.
13. 1 receptors. Brain Res. 710, 79-91.
14. Griffith D. A. and Jarvis S. M. (1996) Nucleoside and nucleobase transport systems of mammalian cells. Biochim. Biophys. Acta 1286, 153-181.
15. Griffiths M., Beaumont N., Yao S. Y. M., Sundaram M., Boumah C. E., Davies A., Kwong F. Y. P., Coe I., Cass C. E., Young J. D., and Baldwin S. A. (1997) Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. Nat. Med. 3, 89-93.
16. Griffiths M., Yao S. Y. M., Abidi F., Phillips S. E. V., Cass C. E., Young J. D., and Baldwin S. A. (1998) Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta. Biochem. J. 328, 739-743.
17. 3H]adenosine in rat cerebral cortical synaptoneurosomes. J. Neurochem. 58, 1699-1705.
18. Gu J. G., Nath A., and Geiger J. D. (1996) Characterization of inhibitor-sensitive and -resistant adenosine transporters in cultured human fetal astrocytes. J. Neurochem. 67, 972-977.
19. Haas H. L. and Greene R. W. (1988) Endogenous adenosine inhibits hippocampal CA1 neurones: further evidence from extra- and intracellular recording. Naunyn Schmiedebergs Arch. Pharmacol. 337, 561-565.
20. Hada J., Kaku T., Morimoto K., Hayashi Y., and Nagai K. (1996) Adenosine transport inhibitors enhance high K(+)-evoked taurine release from rat hippocampus. Eur. J. Pharmacol. 305, 101-107.
21. 3H]nitrobenzylthioinosine to the nucleoside transport system in mammalian central nervous system membranes: evidence for interconvertible conformations of the binding site/transporter complex. J. Neurochem. 45, 527-535.
22. Lee C. W. and Jarvis S. M. (1988) Nucleoside transport in rat cerebral-cortical synaptosomes. Evidence for two types of nucleoside transporters. Biochem. J. 249, 557-564.
23. Miller L. P. and Hsu C. (1992) Therapeutic potential for adenosine receptor activation in ischemic brain injury. J. Neurotrauma 9 (Suppl. 2), S563-S577.
24. Ohkubo T., Mitsumoto Y., and Mohri T. (1991) Characterization of the uptake of adenosine by cultured rat hippocampal cells and inhibition of the uptake by xanthine derivatives. Neurosci. Lett. 133, 275-278.
25. Porkka-Heiskanen T., Strecker R. E., Thakkar M., Bjorkum A. A., Greene R. W., and McCarley R. W. (1997) Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science 276, 1265-1268.
26. 1 adenosine receptor that is widely expressed in brain and spinal cord. Mol. Endocrinol. 5, 1037-1048.
27. Rudolphi K. A., Schubert P., Parkinson F. E., and Fredholm B. B. (1992) Neuroprotective role of adenosine in cerebral ischaemia. Trends. Pharmacol. Sci. 13, 439-445.
28. Sawynok J. ( 1998) Adenosine receptor activation and nociception. Eur. J. Pharmacol. 347, 1-11.
29. 2 receptor-mediated excitatory actions on the nervous system. Prog. Neurobiol. 48, 167-189.
30. Simmons D. M., Arriza J. L., and Swanson L. W. (1989) A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radiolabeled single-stranded RNA probes. J. Histotechnol. 12, 169-181.
31. Sollevi A. (1997) Adenosine for pain control. Acta Anaesthesiol. Scand. Suppl. 110, 135-136.
32. Sweeney M. I. (1996) Adenosine release and uptake in cerebellar granule neurons both occur via an equilibrative nucleoside carrier that is modulated by G proteins. J. Neurochem. 67, 81-88.
33. Tso J. Y., Sun X. H., Kao T. H., Reece K. S., and Wu R. (1985) Isolation and characterization of rat and human glyceraldehyde 3′ phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res. 13, 2485-2502.
34. von Lubitz D. K. J. E., Carter M. F., Beenhakker R., Lin C., and Jacobson K. A. (1997) Adenosine: a prototherapeutic concept in neurodegeneration. Ann. NY Acad. Sci. 825, 163-178.
35. Winn H. R., Rubio R., and Berne R. M. (1981) The role of adenosine in the regulation of cerebral blood flow. J. Cereb. Blood Flow Metab. 1, 239-244.
36. Yao S. Y. M., Ng A. M. L., Muzyka W. R., Griffiths M., Cass C. E., Baldwin S. A., and Young J. D. (1997) Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues. J. Biol. Chem. 272, 28423-28430.
37. Zhang G., Franklin P. H., and Murray T. F. (1993) Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility. J. Pharmacol. Exp. Ther. 264, 1415-1424.