Absolute bioavailability, pharmacokinetics, renal and biliary clearance of distigmine after a single oral dose in comparison to i.v. administration of 14C-distigmine-bromide in healthy volunteers

International Journal of Clinical Pharmacology and Therapeutics

Volumn 37, Issue 8, 1999, Pages 393-403

  Vree, T B ^a   Waitzinger, J ^b   Hammermaier, A ^b   Radhofer Welte, S ^c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b AAI Deutschland GmbH and Co KG   (Germany)

^c Nycomed Holdings AS   (Austria)

Author keywords

Biliary clearance; Distigmine; Human volunteers; Pharmacokinetics; Renal clearance

Indexed keywords

CHOLINESTERASE INHIBITOR; DISTIGMINE; DISTIGMINE BROMIDE; RADIOPHARMACEUTICAL AGENT;

ADULT; ARTICLE; BILIARY EXCRETION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG ELIMINATION; DRUG EXCRETION; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY CLEARANCE; MALE; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL;

ABSORPTION; ADMINISTRATION, ORAL; BILIARY TRACT; BIOLOGICAL AVAILABILITY; CARBON RADIOISOTOPES; CHOLINESTERASE INHIBITORS; CROSS-OVER STUDIES; HUMANS; INJECTIONS, INTRAVENOUS; KIDNEY; MALE; MIDDLE AGED; PYRIDINIUM COMPOUNDS;

EID: 0032777847     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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