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The natural history of pain in alcoholic chronic pancreatitis
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1 Ammann RW, Muellhaupt B: The natural history of pain in alcoholic chronic pancreatitis. Gastroenterology 1999, 116:1132-1140. This is a prospective study of pain patterns and response to therapy in 207 patients with alcoholic chronic pancreatitis. The best predictors of pain relief were an intermittent pattern of pain and the presence of surgically correctable complications.
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Gastroenterology
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Ammann, R.W.1
Muellhaupt, B.2
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A novel mutation in the cystic fibrosis gene in patients with pulmonary disease but normal sweat chloride concentrations
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3 Chillon M, Casals T, Mercier B, Bassas L, Lissens W, Silber S, et al.: Mutations in the cystic fibrosis gene in patients with congenital absence of the vas deferens. N Engl J Med 1995, 332:1475-1480.
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4 Norton ID, Apte MV, Dixson H, Trent RJ, Haber PS, Pirola RC, et al.: Cystic fibrosis genotypes and alcoholic pancreatitis. J Gastroenterol Hepatol 1998, 13:496-499.
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5 Sharer N, Schwarz M, Malone G, Howarth A, Painter J, Super M, et al.: Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. N Engl J Med 1998, 339:645-652.
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6
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Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis
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6 Cohn JA, Friodman KJ, Noone PG, Knowlos MR, Silverman LM, Jowell PS: Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis. N Engl J Med 1998, 339:653-658. References 5 and 6 describe mutations in the CFTR gene in patients with chronic pancreatitis. Most patients had a single mutation, and all had normal sweat chloride, raising the question of functional significance of these findings.
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Cystic Fibrosis Foundation Consensus Panel
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7 Rosenstein BJ, Cutting GR: The diagnosis of cystic fibrosis: a consensus statement. Cystic Fibrosis Foundation Consensus Panel. Pediatrics 1998, 132:589-595. According to the revised criteria, diagnosis of cystic fibrosis can be confirmed by the presence of one or more characteristic phenotypic features (including pancreatitis) plus laboratory evidence of a CFTR-mediated abnormality of ion transport (sweat chloride or nasal potential difference) or the identification of disease-causing mutations in both CFTR genes.
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Rosenstein, B.J.1
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Periacinar stellate shaped cells in rat pancreas: Identification, isolation, and culture
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8 Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, et al.: Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 1998, 43:128-133.
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9
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Identification, culture, and characterization of pancreatic stellate cells in rats and humans
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9 Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, et al.: Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 1998, 115:421-432.
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Bachem, M.G.1
Schneider, E.2
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Pancreatic stellate cells are activated by proinflammatory cytokines: Implications for pancreatic fibrogenesis
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10 Apte MV, Haber PS, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, et al.: Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 1999, 44:534-541. References 9 and 10 show that stellate cells present in rat and human pancreas respond to proinflammatory cytokines by producing collagen. This establishes a significant role for these cells in pancreatic fibrogenesis.
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Gut
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Apte, M.V.1
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Toward understanding (and management) of painful chronic pancreatitis
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11 DiMagno EP: Toward understanding (and management) of painful chronic pancreatitis. Gastroenterology 1999, 116:1252-1256. This editorial accompanying the paper by Ammann and Muellhaupt [1••] summarizes our current understanding of the pathogenesis and management of pain in chronic pancreatitis.
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Gastroenterology
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DiMagno, E.P.1
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Pancreatic stellate cells: The new stars of chronic pancreatitis?
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12 Wells RG, Crawford JM: Pancreatic stellate cells: the new stars of chronic pancreatitis? Gastroenterology 1998, 115:491-493. This editorial accompanying the paper by Bachem et al. [9•] discusses the role of pancreatic stellate cells in pancreatic fibrogenesis.
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Gastroenterology
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Wells, R.G.1
Crawford, J.M.2
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Fibronectin and cytokines increase JNK, ERK, AP-1 activity, and transin gene expression in rat hepatic stellate cells
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13 Poulos JE, Weber JD, Bellezzo JM, Di Bisceglie AM, Britton RS, Bacon BR, et al.: Fibronectin and cytokines increase JNK, ERK, AP-1 activity, and transin gene expression in rat hepatic stellate cells. Am J Physiol 1997, 273(4 pt 1):G804-G811.
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Effect of vitamin E supplementation on hepatic fibrogenesis in chronic dietary iron overload
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14 Brown KE, Poulos JE, Li L, Soweid AM, Ramm GA, O'Neill R, et al.: Effect of vitamin E supplementation on hepatic fibrogenesis in chronic dietary iron overload. Am J Physiol 1997, 272 (1 pt 1 ):G116-G123.
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15
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Prospective evaluation of endoscopic ultrasonography, endoscopic retrograde pancreatography, and secretin test in the diagnosis of chronic pancreatitis
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15 Catalano MF, Lahoti S, Geenen JE, Hogan WJ: Prospective evaluation of endoscopic ultrasonography, endoscopic retrograde pancreatography, and secretin test in the diagnosis of chronic pancreatitis. Gastrointest Endosc 1998, 48:11-17.
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Prospective assessment of the ability of endoscopic ultrasound to diagnose, exclude, or establish the severity of chronic pancreatitis found by endoscopic retrograde cholangiopancreatography
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16 Sahai AV, Zimmerman M, Aabakken L, Tarnasky PR, Cunningham JT, van Velse A, et al.: Prospective assessment of the ability of endoscopic ultrasound to diagnose, exclude, or establish the severity of chronic pancreatitis found by endoscopic retrograde cholangiopancreatography. Gastrointest Endosc 1998, 48:18-25.
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17
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Diagnosing chronic pancreatitis: Shades of gray
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17 Wiersema MJ: Diagnosing chronic pancreatitis: shades of gray. Gastrointest Endosc 1998, 48:102-106. References 15 and 16, with this accompanying editorial, highlight problems with the use of EUS to diagnose "early" chronic pancreatitis. There is poor correlation between EUS and ERCP and the secretin test in patients with few, nonspecific abnormalities on EUS.
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Gastrointest Endosc
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Wiersema, M.J.1
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The surgical management of chronic pancreatitis: Duodenum-preserving pancreatectomy
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18 Beger HG, Schlosser W, Siech M, Poch B: The surgical management of chronic pancreatitis: duodenum-preserving pancreatectomy. Adv Surg 1999, 32:87-104.
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Medical position statement: Treatment of pain in chronic pancreatitis
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19 American Gastroenterological Association: Medical position statement: treatment of pain in chronic pancreatitis. Gastroenterology 1998, 115:763-764.
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AGA technical review: Treatment of pain in chronic pancreatitis
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20 Warshaw AL, Banks PA, Fernandez-Del Castillo C: AGA technical review: treatment of pain in chronic pancreatitis. Gastroenterology 1998, 115:765-776. This review of studies supporting various treatment strategies for pain in chronic pancreatitis highlights the lack of controlled studies supporting any form of therapy.
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Gastroenterology
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Warshaw, A.L.1
Banks, P.A.2
Fernandez-Del Castillo, C.3
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Pancreatitis and the risk of pancreatic cancer
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21 Lowenfels AB, Maisonneuve P, Cavallini G, Ammann RW, Lankisch PG, Andersen JR, et al.: Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med 1993, 328: 1433-1437.
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Risk of pancreatic carcinoma in tropical calcifying pancreatitis: An epidemiologic study
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22 Chari ST, Mohan V, Pitchumoni CS, Viswanathan M, Madanagopalan N, Lowenfels AB: Risk of pancreatic carcinoma in tropical calcifying pancreatitis: an epidemiologic study. Pancreas 1994, 9:62-66.
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Hereditary pancreatitis and the risk of pancreatic cancer
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23 Lowenfels AB, Maisonneuve P, DiMagno EP, Elitsur Y, Gates LK Jr, Perrault J, et al.: Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J Natl Cancer Inst 1997, 89:442-446.
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Progression of pancreatic intraductal neoplasias to infiltrating adenocarcinoma of the pancreas
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Epithelial anomalies in chronic pancreatitis as a risk factor of pancreatic cancer
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25 Cylwik B, Nowak HF, Puchalski Z, Barczyk J: Epithelial anomalies in chronic pancreatitis as a risk factor of pancreatic cancer. Hepatogastroenterology 1998, 45:528-532. This study of biopsy material from 70 patients with clinically diagnosed advanced chronic pancreatitis shows that a spectrum of histologic changes described in pancreatic carcínogenesís also occurs in chroníc pancreatítís.
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K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatíc diseases
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26 Berndt C, Haubold K, Wenger F, Brux B, Muller J, Bendzko P, et al.: K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatíc diseases. Clin Chem 1998, 44:2103-2107.
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28 Gansauge S, Schmid RM, Muller J, Adler G, Mattfeldt T, Beger HG: Genetic alterations in chronic pancreatitis: evidence for early occurrence of p53 but not K-ras mutations. Br J Surg 1998, 85:337-340.
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