An improved deprotection procedure of amine-containing oligonucleotides from acrylonitrile modification

Nucleosides and Nucleotides

Volumn 18, Issue 6-7, 1999, Pages 1205-1206

  Chang, Chu An ^a   Horn, Thomas ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLONITRILE; AMMONIUM DERIVATIVE; AMMONIUM HYDROXIDE; BUTYLAMINE; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ALKYLATION; CHEMICAL MODIFICATION; CONFERENCE PAPER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROTECTION; REACTION ANALYSIS; SEQUENCE ANALYSIS; STANDARD;

EID: 0032774430     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319908044663     Document Type: Conference Paper

References (5)

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2. Urdea, M. S., Warner, B.D., Running, J.A., Stempien, M., Clyne, J. and Horn, T. Nucleic Acids Res., 1988, 16, 4937-56.
3. Sinha, N. D., Biernat, J., McManus, J. and Koster, H. Nucleic Acids Res., 1984, 12, 4539-4557.
4. Eadie, J. S., McBride, L.J., Efcavitch, J.W., Hoff, L.B. and Cathcart, R. Analytical Biochemistry, 1987, 165, 442-447.
5. 3COD) 1.3 (m, 2H), 1.4 (t, 2H), 1.5-1.6 (m, 4H), 1.95 (s, 3H), 2.1-2.3 (m, 4H), 2.55 (t, 2H), 2.85 (t, 2H).