Synthetic peptide sequence from the C-terminus of the insulin-like growth factor-I receptor that induces apoptosis and inhibition of tumor growth

Journal of Cellular Physiology

Volumn 181, Issue 1, 1999, Pages 124-135

  Reiss, Krzysztof ^a   Yumet, Gladys ^a   Shan, Simei ^a   Huang, Ziwei ^a   Alnemri, Emad ^a   Srinivasula, Srinivasa M ^a   Wang, Jin Ying ^a   Morrione, Andrea ^a   Baserga, Renato ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURVIVAL; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; GROWTH INHIBITION; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; TUMOR GROWTH;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CASPASES; CELL DEATH; CELL DIVISION; DNA; ENZYME ACTIVATION; FIBROBLASTS; HUMANS; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; NEOPLASM TRANSPLANTATION; PEPTIDE FRAGMENTS; RECEPTOR, IGF TYPE 1; TUMOR CELLS, CULTURED;

EID: 0032773862     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199910)181:1<124::AID-JCP13>3.0.CO;2-0     Document Type: Article

References (73)

1. Baserga R. 1997. The price of independence. Exp Cell Res 236:1-3.
2. Baserga R, Hongo A, Rubini M, Prisco M, Valentinis B. 1997. The IGF-I receptor in cell growth, transformation and apoptosis. Biochim Biophys Acta 1332:105-126.
3. Burfeind P, Chernicky CL, Rininsland F, Ilan J, Ilan I. 1996. Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo. Proc Natl Acad Sci USA 93:7263-7268.
4. Craparo A, O'Neill TJ, Gustafson TA. 1995. Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor-I receptor. J Biol Chem 270:15639-15643.
5. Craparo A, Freund R, Gustafson TA. 1997. 14.3.3 interacts with the insulin-like growth factor I receptor and insulin receptor substrate 1 in a phosphoserine-dependent manner. J Biol Chem 272:11663-11669.
6. D'Ambrosio C, Ferber A, Resnicoff M, Baserga R. 1996. A soluble insulin-like growth factor I receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis. Cancer Res 56:4013-4020.
7. D'Ambrosio C, Valentinis B, Prisco M, Reiss K, Rubini M, Baserga R. 1997. Protective effect of the IGF-I receptor on apoptosis induced by okadaic acid. Cancer Res 57:3264-3271.
8. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
9. Day ML, Foster RG, Day KC, Zhao X, Humphrey P, Swanson P, Postigo AA, Zhang SH, Dean DC. 1997. Cell anchorage regulates apoptosis through the retinoblastoma tumor suppressor/E2F pathway. J Biol Chem 272:8125-8128.
10. Dews M, Nishimoto I, Baserga R. 1997. IGF-I receptor protection from apoptosis in cells lacking the IRS proteins. Receptors Signal Transduc 7:231-239.
11. Dudek H, Datta SR, FrankeTF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR Greenberg ME. 1997. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665.
12. Dunn SE, Hardman RA, Kari FW, Barrett CJ. 1997. Insulin-like growth factor 1 (IGF-I) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs. Cancer Res 57:2687-2693.
13. Dunn SE, Ehrlich M, Sharp NJH, Reiss K, Solomon G, Hawkins R, Baserga R, Barrett JC. 1998. A dominant negative mutant of the insulin-like growth factor 1 receptor inhibits the adhesion, invasion and metastasis of breast cancer. Cancer Res 58:3353-3361.
14. Frisch SM, Francis H. 1994. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 124:619-626.
15. Furlanetto RW, Dey BR, Lopaczynski W, Nissley SP. 1997. 14.3.3 proteins interact with the insulin-like growth factor receptor but not with the insulin receptor. Biochem J 327:765-771.
16. Harrington EA, Bennett MR, Fanidi A, Evan GI. 1994. c-myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J 13:3286-3295.
17. Kongo A, D'Ambrosio C, Miura M, Morrione A, Baserga R. 1996. Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor. Oncogene 12:1231-1238.
18. Hongo A, Yumet G, Resnicoff M, Romano G, O'Connor R, Baserga R. 1998. Inhibition of tumorigenesis and induction of apoptosis in human tumor cells by the stable expression of a myristylated COOH terminus of the insulin-like growth factor I receptor. Cancer Res 58:2477-2484
19. Hsing AY, Kadomatsu K, Bonham NJ, Danielpour D. 1996. Regulation of apoptosis induced by transforming growth factor β1 in non-tumorigenic and tumorigenic rat prostatic epithelial cell lines. Cancer Res 56:5146-5149.
20. Hugl SR, White M, Rhodes CJ. 1998. Insulin-like growth factor 1 (IGF-I)-stimulated pancreatic β-cell growth is glucose-dependent. J Biol Chem 273:17771-17779.
21. Khokhlatchev AV, Canagarajah B, Wilsbacher J, Robinson M, Atkinson M, Goldsmith E, Cobb MH. 1998. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell 93:605-615.
22. King WG, Mattaliano MD, Chan TO, Tsichlis PN, Brugge JS. 1997. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation. Mol Cell Biol 17:4406-4418.
23. Kluck RM, Bossy-Werzel E, Green DR, Newmeyer DD. 1997. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136.
24. Kole HK, Liotta AS, Kole S, Roth J, Montrose-Rafizadeh C, Bernier M. 1996. A synthetic peptide derived from a COOH-terminal domain of the insulin receptor specifically enhances insulin receptor signaling. J Biol Chem 271:31619-31626.
25. Kulik G, Klippel A, Weber MJ. 1997. Antiapoptotic signaling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 17:1595-1606.
26. 2+ fluxes. Proc Natl Acad Sci USA 91:6569-6573.
27. Lebowitz PF, Sakamuro D, Prendergast G. 1997. Farnesyl transferase inhibitors induce apoptosis of ras-transformed cells denied substratum attachment. Cancer Res 57:708-713.
28. Lee CT, Wu S, Gabrivolich D, Chen H, Nadaf-Rahrov S, Ciernick IF, Carbone DP. 1996. Antitumor effect of an adenovirus expressing antisense insulin-like growth factor I receptor on human lung cancer cell lines. Cancer Res 56:3038-3041.
29. Liu Y, Lehar S, Corvi C, Payne G, Chittenden T, O'Connor R. 1998. Expression of the IGF-I receptor C-terminus as a myristylated protein leads to induction of apoptosis in tumor cells. Cancer Res 58:570-576.
30. Long L, Rubin R, Baserga R, Brodt P. 1995. Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor I receptor. Cancer Res 55:1006-1009.
31. McCubrey JA, Stillman LS, Mayhew MW, Algate PA, Dellow RA, Kaleko M. 1991. Growth promoting effects of insulin-like growth factor 1 (IGF-1) on hematopoietic cells. Overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor dependent cells by ligand dependent mechanism. Blood 78:921-929.
32. Miura M, Surmacz E, Burgaud JL, Baserga R. 1995. Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor. J Biol Chem 38:22639-22644.
33. Morrione A, Valentinis B, Xu SQ, Yumet G, Louvi A, Efstratiadis A, Baserga R. 1997. Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proc Natl Acad Sci USA 94:3777-3782.
34. Nakamura S, Watanabe H, Miura M, Sasaki T. 1997. Effect of the insulin-like growth factor 1 receptor on ionizing radiation-induced cell death in mouse embryo fibroblasts. Exp Cell Res 235:287-294.
35. Neuenschwander S, Roberts Jr CT, LeRoith D. 1995. Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor 1 receptor antisense ribonucleic acid. Endocrinology 136:4298-4303.
36. O'Connor R, Kauffmann-Zeh A, Liu Y, Lehar S, Evan GI, Baserga R, Blattler WA. 1997. The IGF-I receptor domains for protection from apoptosis are distinct from those required for proliferation and transformation. Mol Cell Biol 17: 427-435.
37. Pass HL, Mew DJY, Carbone M, Matthews WA, Domington JS, Baserga R, Walker CL, Resnicoff M, Steinberg SM. 1996. Inhibition of hamster mesothelioma tumorigenesis by an antisense expression plasmid to the insulin-like growth factor I receptor. Cancer Res 56:4044-4048.
38. Passaniti A, Isaacs JT, Haney JA, Adler SW, Cujdik TJ, Long PV, Kleinman HK. 1992. Stimulation of human prostatic carcinoma tumor growth in athymic mice and control of migration in culture by extracellular matrix. Int J Cancer 51:318-324.
39. Pietrzkowski Z, Lammers R, Carpenter G, Soderquist AM, Limardo M, Phillips PD, Ullrich A, Baserga R. 1992. Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors. Cell Growth Differ 3:199-205.
40. Prager D, Li HL, Asa S, Melmed S. 1994.Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor receptor mutant. Proc Natl Acad Sci USA 91:2181-2185.
41. Prisco M, Kongo A, Rizzo MG, Sacchi A, Baserga R. 1997. The IGF-I receptor as a physiological relevant target of p53 in apoptosis caused by interleukin-3 withdrawal. Mol Cell Biol 17:1084-1092.
42. Pronk GJ, McGlade J, Pelicci G, Pawson T, Bos JL. 1993. Insulin-induced phosphorylation of the 46- and 52-kDa She proteins. J Biol Chem 268:5748-5753.
43. Pruett W, Yuan Y, Batzer AG, Harada N, Skolnik EY. 1995. Association of Grb2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for ras activation. Mol Cell Biol 15:1778-1785.
44. Rak J, Mitsuhashi Y, Erdos V, Huang S, Filmus J, Kerbel R. 1995. Massive programmed cell death in intestinal epithelial cells induced by three-dimensional growth conditions: suppression of mutant c-H-ras oncogene expression. J Cell Biol 131:1587-1598.
45. Reed JC. 1994. Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1-6.
46. Reiss K, D'Ambrosio C, Tu X, Tu C, and Baserga R. 1998a. Inhibition of tumor growth by a dominant negative mutant of the insulin-like growth factor I receptor with a bystander effect. Clin Cancer Res 4:2647-2655.
47. Reiss K, Valentinis B, Tu X, Xu SQ, Baserga R. 1998b. Molecular markers of IGF-I-mediated mitogenesis. Exp Cell Res 242:361-372.
48. Resnicoff M, Coppola D, Sell C, Rubin R, Ferrone S, Baserga R. 1994a. Growth inhibition of human melanoma cells in nude mice by antisensense strategies to the type 1 insulin-like growth factor receptor. Cancer Res 54:4848-4850.
49. Resnicoff M, Sell C, Rubini M, Coppola D, Ambrose D, Baserga R, Rubin R. 1994b. Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor I (IGF-I) receptor are nontumorigenic and induce regression of wild-type tumors. Cancer Res 54:2218-2222.
50. Resnicoff M, Valentinis B, Herbert D, Abraham D, Friesen PD, Alnemri ES, Baserga R. 1998. The baculovirus anti-apoptotic p35 protein promotes transformation of mouse embryo fibroblasts. J Biol Chem 273:10376-10380.
51. Rininsland F, Johnson TR, Chernicky CL, Schulze E, Burfeind B, Ilan J, and Ilan J. 1997. Suppression of insulin-like growth factor I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells. Proc Natl Acad SCi 94:5854-5859.
52. Rodriguez-Tarduchy G, Collins MKL, Garcia I, Lopez-Rivas A. 1992. Insulin-like growth factor I inhibits apoptosis in IL-3 dependent hemopoietic cells. J Immunol 149:535-540.
53. Romano G, Prisco M, Zanocco-Marani T, Peruzzi F, Valentinis B, Baserga R. 1999. Dissociation between resistance to apoptosis and the transformed phenotype in IGF-I receptor signaling. J Cell Biochem 72:294-310.
54. Rubini M, Hongo A, D'Ambrosio C, Baserga R. 1997. The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor number. Exp Cell Res 230:284-292.
55. Sasaoka T, Rose DW, Jhun BH, Saltiel AR, Draznin B, Olefsky JM. 1994. Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J Biol Chem 269:13689-13694.
56. Satoh T, Aramini JM, Li S, Friedman TM, Gao J, Edling AE, Townsend R, Koch U, Choksi S, Germann MW, Korngold R, Huang Z. 1997. Bioactive peptide design based on protein surface epitopes. J Biol Chem 272:12175-12180.
57. Seely BL, Reichart DR, Staubs PA, Jhun BH, Hsu D, Maegawa H, Milarski KL, Saltiel AR, Olefsky JM. 1995. Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp and GTPase activating protein. J Biol Chem 270:19151-19157.
58. Sell C, Dumenil G, Deveaud C, Miura M, Coppola D, DeAngelis T, Rubin R, Efstratiadis A, Baserga R. 1994. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasta. Mol Cell Biol 14:3604-3612.
59. Sell C, Baserga R, Rubin R. 1995. Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis. Cancer Res 55:303-306.
60. Shapiro DN, Jones BG, Shapiro LH, Dias P, Houghton PJ. 1994. Antisense-mediated reduction in insulin-like growth factor 1 receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma. J Clin Invest 94:1235-1242.
61. Souroujon MC, Mochly-Rosen D. 1998. Peptide modulators of protein-protein interactions in intracellular signaling. Nature Biotech 16: 919-924.
62. Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES. 1998. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell 1:949-957.
63. Staubs PA, Nelson JG, Reichart DR, Olefsky JM. 1998. Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without affecting glucose transport. J Biol Chem 273: 25139-25147.
64. Tartare-Deckert S, Sawka-Verheile D, Murdaca J, van Obberghen E. 1996. Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system. J Biol Chem 271: 23456-23460.
65. Turner BC, Haffty BG, Narayanan L, Yuan J, Havre PA, Gumbs AA, Kaplan L, Burgaud JL, Carter D, Baserga R, Glazer PM. 1997. Insulin-like growth factor 1 receptor overexpression mediates cellular resistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res 57:3079-3083.
66. Valentinis B, Reiss K, Baserga R. 1998. Insulin-like growth factor-1-mediated survival from anoikis: role of cell aggregation and focal adhesion kinase. J Cell Physiol 176:648-657.
67. Valentinis B, Morrione A, Peruzzi F, Prisco M, Reiss K, Baserga R. 1999. Anti-apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion. Oncogene (in press).
68. Wallenstein S, Zucker CL, Fleiss JL. 1980 Some statistical methods useful in circulation research. Circ Res 47:1-9.
69. Williams EJ, Dunican DJ, Green PJ, Howell FV, Derossi D, Walsh FS, Doherty P. 1997. Selective inhibition of growth factor-stimulated mitogenesis by a cell permeable Grb2-binding peptide. J Biol Chem 272:22349-22354.
70. Wu Y, Tewari M, Cui S, Rubin R. 1996. Activation of the insulin-like growth factor I receptor inhibits tumor necrosis factor-induced cell death. J Cell Physiol 168:499-509.
71. Xu F, Gardner A, Tu Y, Michl P, Prager D, Lichtenstein A. 1997. Multiple myeloma cells are protected against dexamethasone-induced apoptosis by insulin-like growth factors. Br J Haematol 97:429-440.
72. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X. 1997. Prevention of apoptosis by Bcl-2: release of cytochrome C from mitochondria blocked. Science 275:1129-1132.
73. Zhou-Li F, Xu SQ, Dews M, Baserga R. 1997. Co-operation of simian virus 40 T antigen and insulin receptor substrate-1 in protection from apoptosis induced by interleukin-3 withdrawal. Oncogene 15:961-970.