Characterization of the carrier-mediated transport of levofloxacin, a fluoroquinolone antimicrobial agent, in rabbit cornea

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 7, 1999, Pages 797-801

  Kawazu, Kouichi ^a   Midori, Yukari ^a   Shiono, Hiromitsu ^a   Ota, Atsutoshi ^a  

^a SANTEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG CARRIER; LEVOFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANIMAL TISSUE; ARTICLE; CORNEA; CORNEA ENDOTHELIUM; CORNEA EPITHELIUM; DRUG PENETRATION; DRUG TRANSPORT; MALE; NONHUMAN; RABBIT;

ANIMALS; ANTI-INFECTIVE AGENTS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CORNEA; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN-ION CONCENTRATION; MALE; OFLOXACIN; PERMEABILITY; RABBITS; TEMPERATURE;

EID: 0032772781     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991773168     Document Type: Article

References (18)

1. Fukuda, M., Sasaki, K. (1995) In vitro topically applied fluoroquinolone penetration into the anterior chamber. J. Jpn. Ophthalmol. Soc. 99: 532-536
2. Grass, G. M., Robinson, J. R. (1988) Mechanisms of corneal drug penetration I: in vivo and in vitro kinetics. J. Pharm. Sci. 77: 3-14
3. Griffiths, N. M., Hirst, B. H., Simmons, N. H. (1993) Active secretion of the fluoroquinolone ciprofloxacin by human intestinal epithelial Caco-2 cell layers. Br. J. Pharmacol. 108: 575-576
4. Griffiths, N. M., Hirst, B. H., Simmons, N. H. (1994) Active intestinal secretion of fluoroquinolone antibacterials ciprofloxacin, norfloxacin and pefloxacin; a common secretory pathway? J. Pharmacol. Exp. Ther. 269: 496-502
5. Hayakawa, I., Atarashi, S., Yokohama, S., Imamura, M., Sakano, K., Furukawa, M. (1986) Synthesis and antibacterial activities of optically active ofloxacin. Antimicrob. Agents Chemother. 29: 163-164
6. Hirano, T., Iseki, K., Sato, I., Miyazaki, S., Takada, M., Kobayashi, M., Sugawara, M., Miyazaki, K. (1995a) The intestinal transport mechanism of fluoroquinolones: inhibitory effect of ciprofloxacin, an enoxacin derivative, on the membrane potential-dependent uptake of enoxacin. Pharm. Res. 12: 1299-1303
7. Hirano, T., Iseki, K., Sugawara, M., Miyazaki, S., Takada, M., Miyazaki, K. (1995b) Transport mechanisms of enoxacin in rat brush-border membrane of renal cortex: interaction with organic cation transport system and ionic diffusion potential dependent uptake. Biol. Pharm. Bull. 18: 342-346
8. Kawashima, Y., Takashina, H., Usui, M. (1995) Pharmacokinetic parameters of ofloxacin ophthalmic solutions. Atarashii Ganka (Journal of the Eye) 12: 791-794
9. Kawazu, K., Takashina, H., Kawashima, Y., Usui, M., Mitsui, Y. (1996) Effect of pH on the ocular penetration of levo-floxacin. Atarashii Ganka (Journal of the Eye) 13: 259-262
10. 1: interaction with organic transporters in apical and basolateral membranes. J. Pharmacol. Exp. Ther. 276: 1143-1148
11. Okano, T., Maegawa, H., Inui, K., Hori, R. (1990) Interaction of ofloxacin with organic cation transport system in rat renal brush-border membranes. J. Pharmacol. Exp. Ther. 255: 1033-1037
12. Prieto, J. G., Barrio, J. P., Alvarez, A. I., Ǵornez, G. (1988) Kinetics mechanism for the intestinal absorption of ofloxacin. J. Pharm. Pharmacol. 40: 211-212
13. Rabbaa, L., Dautrey, S., Colas-Linhart, N., Carbon, C., Farinotti, R. (1996) Intestinal elimination of ofloxacin enantiomers in the rat: evidence of a carrier-mediated process. Antimicrob. Agents Chemother. 40: 2126-2130
14. Sasaki, K., Mitsui, Y., Fukuda, M., Ooishi, M., Ohashi, Y. (1995) Intraocular penetration mode of five fluoroquinolone ophthalmic solutions evaluated by newly proposed parameter of AQCmax. Atarashii Ganka (Journal of the Eye) 12: 787-790
15. Simanjuntak, M. T., Sato, H., Tamai, I., Terasaki, T., Tsuji, A. (1991) Transport of the new quinolone antibacterial agents of lomefloxacin and ofloxacin by rat erythrocytes, and its relation to the nicotinic acid transport system. J. Pharmacobio-Dyn. 14: 475-481
16. Terasaki, T., Deguchi, Y., Kasama, Y., Pardridge, W. M., Tsuji, A. (1992) Determination of in vivo steady-state unbound drug concentration in the brain interstitial fluid by microdialysis. Int. J. Pharm. 81: 143-152
17. Une, T., Fujimoto, T., Sato, K., Osada, Y. (1988) In vitro activity of DR-3355, an optically active ofloxacin. Antimicrob. Agents Chemother. 32: 1336-1340
18. Yamaoka, K., Tanigawara, T., Nakagawa, T., Uno, T. (1981) A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobio-Dyn. 4: 879-885