Analysing the developing lymphocyte system of neonates and infants

European Journal of Pediatrics

Volumn 158, Issue 8, 1999, Pages 611-617

  De Vries, E ^b,c   De Groot, R ^a   De Bruin Versteeg, S ^a,b   Comans Bitter, W M ^a,b   Van Dongen, J J M ^b  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^c JEROEN BOSCH HOSPITAL   (Netherlands)

Author keywords

Flow cytometry; Immunophenotyping; Infant; Lymphocyte subsets; Neonate

Indexed keywords

ANTIGEN EXPRESSION; B LYMPHOCYTE; CHILD DEVELOPMENT; FLOW CYTOMETRY; HUMAN; IMMUNOPHENOTYPING; LYMPHOCYTE DIFFERENTIATION; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE SUBPOPULATION;

HUMANS; IMMUNOPHENOTYPING; INFANT; INFANT, NEWBORN; LYMPHATIC SYSTEM; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; LYMPHOCYTES;

EID: 0032772561     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004310051162     Document Type: Review

References (50)

1. Aldhous MC, Raab GM, Doherty KV, Mok JYQ, Bird AG, Froebel KS (1994) Age-related ranges of memory, activation, and cytotoxic markers on CD4 and CD8 cells in children. J Clin Immunol 14:289-298
2. Andersson U, Bird G, Britton S (1980) Cellular mechanisms of restricted immunoglobulin formation in the human neonate. Eur J Immunol 10:888-894
3. Beck R, Lam-Po-Tang PRL (1994) Comparison of cord blood and adult blood lymphocyte normal ranges: a possible explanation for decreased severity of graft versus host disease after cord blood transplantation. Immunol Cell Biol 72:440-444
4. Bertotto A, Gerli R, Lanfrancone L, Crupi S, Arcangeli C, Cernetti C, Spinozzi F, Rambotti P (1990) Activation of cord T lymphocytes. II. Cellular and molecular analysis of the defective response induced by anti-CD3 monoclonal antibody. Cell Immunol 127:247-259
5. Brugnoni D, Airò P, Graf D, Marconi M, Lebowitz M, Plebani A, Giliani S, Malacarne F, Cattaneo R, Ugazio AG, et al (1994) Ineffective expression of CD40 ligand on cord blood T cells may contribute to poor immunoglobulin production in the newborn. Eur J Immunol 24:1919-1924
6. Carver JD, Pimentel B, Wiener DA, Lowell NE, Barness LA (1991) Infant feeding effects on flow cytometric analysis of blood. J Clin Lab Anal 5:54-56
7. Clerici M, De Palma L, Roilides E, Baker R, Shearer GM (1993) Analysis of T helper and antigen-presenting cell functions in cord blood and peripheral blood leukocytes from healthy children of different ages. J Clin Invest 91:2829-2836
8. Comans-Bitter WM, De Groot R, Van den Beemd R, Neijens HJ, Hop WCJ, Groeneveld K, et al (1997) Immunophenotyping of blood lymphocytes in childhood. Reference values for lymphocyte subpopulations. J Pediatr 130:388-393
9. Denny T, Yogev R, Gelman R, Skuza C, Oleske J, Chadwick E, Cheng S, Connor E (1992) Lymphocyte subsets in healthy children during the first 5 years of life. J Am Med Assoc 267:1484-1488
10. De Vries E, De Bruin-Versteeg S, Comans-Bitter WM, De Groot R, Boerma GJM, Lotgering FK, Van Dongen JJM (1999) Correction for erythroid cell contamination in microassay for immunophenotyping of neonatal lymphocytes. Arch Dis Child (in press)
11. Durandy A, Thuillier L, Forveille M, Fischer A (1990) Phenotypic and functional characteristics of human newborns' B lymphocytes. J Immunol 144:60-65
12. Ehlers S, Smith KA (1991) Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. J Exp Med 173:25-36
13. English KB, Burchett SK, English JD, Ammann AJ, Wara DW, Wilson CB (1988) Production of lymphotoxin and tumor necrosis factor by human neonatal mononuclear cells. Pediatr Res 24:717-722
14. Erkeller-Yuksel FM, Deneys V, Yuksel B, Hannet I, Hulstaert F, Hamilton C, et al (1991) Age-related changes in human blood lymphocyte subpopulations. J Pediatr 120:216-222
15. Foa R, Giubellino MC, Fierro MT, Lusso P, Ferrando ML (1984) Immature T lymphocytes in human cord blood identified by monoclonal antibodies: a model for the study of the diffentiation pathway of T cells in humans. Cell Immunol 89:194-201
16. Fuleihan R, Ahern D, Geha RS (1994) Decreased expression of the ligand for CD40 in newborn lymphocytes. Eur J Immunol 24:1925-1928
17. Gerli R, Bertotto A, Crupi S, Arcangeli C, Marinelli I, Spinozzi F, Cernetti C, Angelella P, Rambotti P (1989) Activation of cord T lymphocytes. I. Evidence for a defective T cell mitogenesis induced through the CD2 molecule. J Immunol 142:2583-2589
18. Gerli R, Rambotti P, Cernetti C, Velardi A, Spinozzi F, Tabilio A, Martelli MF, Grignani F, Davis S (1984) A mature thymocyte-like phenotypic pattern on human cord circulating T-lymphoid cells. J Clin Immunol 4:461-468
19. Griffiths-Chu S, Patterson JAK, Berger CL, Edelson RL, Chu AC (1984) Characterization of immature T cell subpopulations in neonatal blood. Blood 64:296-300
20. Groeneveld K, Te Marvelde JG, Van den Beemd R, Slijkoord EJ, Hooijkaas H, Van Dongen JJM (1994) Detection of intracellular antigens (in Dutch). In: Van Dongen JJM, Groeneveld K, Adriaansen HJ, Hooijkaas H (eds) Immunophenotyping in diagnostics: indications, execution, and interpretation (in Dutch). Department of Immunology, Erasmus University Rotterdam, Rotterdam, pp 63-73
21. Heldrup J, Kalm O, Prellner K (1992) Blood T and B lymphocyte subpopulations in healthy infants and children. Acta Paediatr 81:125-132
22. Iatropoulos MJ, Williams GM (1996) Proliferation markers. Exp Toxicol Pathol 48:175-181
23. Ibegbu C, Spira TJ, Nesheim S, Mendez H, Lee F, Polliotti B, Caba J, Nahmias A (1994) Subpopulations of T and B cells in perinatally HIV-infected and noninfected age-matched children compared with those in adults. Clin Immunol Immunopathol 71:27-32
24. Kotylo PK, Baenzinger JC, Yoder MC, Engle WA, Bolinger CD (1990) Rapid analysis of lymphocyte subsets in cord blood. Am J Clin Pathol 93:263-266
25. Kotylo PK, Fineberg NS, Freeman KS, Redmond NL, Charland C (1992) Reference ranges for lymphocyte subsets in pediatric patients. Hematopathol 100:111-115
26. Kutvirt SG, Lewis SL, Simon TL (1993) Lymphocyte phenotypes in infants are altered by separation of blood on density gradients. Br J Biomed Sci 50:321-328
27. Lewis DB, Wilson CB (1995) Developmental immunology and role of host defences in neonatal susceptibility to infection. In: Remington JS, Klein JO (eds) Infectious diseases of the fetus and newborn infant. Saunders, Philadelphia, pp 20-98
28. Lewis DB, Larsen A, Wilson CB (1986) Reduced interferon-gamma mRNA levels in human neonates. J Exp Med 163:1018-1023
29. Lewis DB, Yu CC, Meyer J, English BK, Kahn SJ, Wilson CB (1991) Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells. J Clin Invest 87:194-202
30. Loken MR, Brosnan JM, Bach BA, Ault KA (1990) Establishing optimal lymphocyte gates for immunophenotyping by flow cytometry. Cytometry 11:453-459
31. Lucivero G, Dell'Osso A, Iannone A, Selvaggi L, Antonaci S, Bettocchi S, Bonomo L (1983) Phenotypic immaturity of T and B lymphocytes in cord blood of full-term normal neonates. Analysis of cell surface markers by using conventional techniques and monoclonal antibodies. Biol Neonate 44:303-308
32. Maccario R, Nespoli L, Mingrat G, Vitiello A, Ugazio AG, Burgio GR (1983) Lymphocyte subpopulations in the neonate: identification of an immature subset of OKT8-positive, OKT3-negative cells. J Immunol 130:1129-1131
33. Moretta A, Valtorta A, Chirico G, Chiara A, Bozzola M, DeAmici M, Maccario R (1991) Lymphocyte subpopulations in preterm infants: high percentage of cells expressing p55 chain of interleukin-2 receptor. Biol Neonate 59:213-218
34. North ME, Ivory K, Funauchi M, Webster AD, Lane AC, Farrant J (1996) Intracellular cytokine production by human CD4+ and CD8+ T cells from normal and immunodeficient donors using directly conjugated anti-cytokine antibodies and three-colour flow cytometry. Clin Exp Immunol 105:517-522
35. Oski F (1993) The erythrocyte and its disorders. In: Nathan D, Oski F (eds) Hematology of infancy and childhood, 4th edn. Saunders, Philadelphia, pp 18-43
36. Pilarski LM, Yacyshyn BR, Jensen GS, Pruski E, Pabst HF (1991) Betal integrin (CD29) expression on human postnatal T cell subsets defined by selective CD45 isoform expression. J Immunol 147:830-837
37. Porta FA, Maccario R, Ferrari FA, Alberini CM, Montagna D, DeAmici M, Gianetti A, Ugazio AG (1985) Lymphocyte subpopulations in the neonate: high percentage of ANAE+ cells with low avidity for sheep erythrocytes. Thymus 7:263-269
38. Reason DC, Ebisawa M, Saito H, Nagakura T, Iikura Y (1990) Human cord blood lymphocytes do not simultaneously express CD4 and CD8 cell surface markers. Biol Neonate 58:87-90
39. Remy N, Oberreit M, Thoenes G, Wahn U (1991) Lymphocyte subsets in whole blood and isolated mononuclear leucocytes of healthy infants and children. Eur J Pediatr 150:230-233
40. Samelson R, Larkey DM, Amankwah KS, McConnachie P (1992) Effect of labor on lymphocyte subsets in full-term neonates. Am J Reprod Immunol 28:71-73
41. Sancho L, DeLaHera A, Casas J, Vaquer S, Martínez-A C, Alvarez-Mon M (1991) Two different maturational stages of natural killer lymphocytes in human newborn infants. J Pediatr 119:446-454
42. Seki H, Taga K, Matsuda A, Uwadana N, Hasui M, Miyawaki T, Taniguchi N (1986) Phenotypic and functional characteristics of active suppressor cells against IFN-gamma production in PHA-stimulated cord blood lymphocytes. J Immunol 137:3158-3161
43. Smith MA, Evans J, Steel CM (1974) Age-related variation in proportion of circulating T cells. Lancet 922-924
44. Solinger AM (1985) Immature T lymphocytes in human neonatal blood. Cell Immunol 92:115-122
45. Splawski JB, Lipsky PE (1991) Cytokine regulation of immunoglobulin secretion by neonatal lymphocytes. J Clin Invest 88:967-977
46. Splawski JB, Jelinek DF, Lipsky PE (1991) Delineation of the functional capacity of human neonatal lymphocytes. J Clin Invest 87:545-553
47. Taylor S, Bryson YJ (1984) Impaired production of gamma-interferon by newborn cells in vitro is due to a functionally immature macrophage. J Immunol 134:1493-1497
48. Wakasugi N, Virelizier J (1985) Defective IFN-gamma production in the human neonate. I. Dysregulation rather than intrinsic abnormality. J Immunol 134:167-171
49. Wakasugi N, Virelizier J, Arenzana-Seisdedos F, Rothhut B, Mencia Huerta J, Russo-Marie F, Fiers W (1985) Defective IFN-gamma production in the human neonate. II. Role of increased sensitivity to the suppressive effects of prostaglandin. Eur J Immunol 134:172-176
50. Wilson CB, Westall J, Johnston L, Lewis DB, Dower SK, Alpert AR (1986) Decreased production of interferon-gamma by human neonatal cells. Intrinsic and regulatory deficiencies. J Clin Invest 77:860-867