Development of an unconventional in vitro drug release test method for a bile acid sequestrant, DMP 504, tablet

Pharmaceutical Research

Volumn 16, Issue 7, 1999, Pages 1136-1139

  Wu, Lei Shu ^a   McCormick, Timothy J ^a   Chang, Rong Kun ^a   Pang, Josephine ^a   McCummings, Tom ^a   Ramos, Miriam ^a   Hussain, Munir A ^a  

^a DUPONT COMPANY   (United States)

Author keywords

Bile acid sequestrant; Dissolution; DMP 504; In vitro release; Reverse binding

Indexed keywords

BILE ACID; COLESTIPOL; COLESTYRAMINE; DMP 504;

ARTICLE; BINDING AFFINITY; DISSOCIATION; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; TABLET;

ANTICHOLESTEREMIC AGENTS; ANTILIPEMIC AGENTS; BILE ACIDS AND SALTS; CALIBRATION; CHEMISTRY, PHARMACEUTICAL; CHOLESTYRAMINE; COLESTIPOL; LINEAR MODELS; POLYMERS; QUATERNARY AMMONIUM COMPOUNDS; TABLETS;

EID: 0032771888     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011916723251     Document Type: Article

References (6)

1. G. M. Benson, C. Haynes, S. Blanchard, and D. Ellis. In vitro studies to investigate the reasons for the low potency of cholestyramine and colestipol. J. Pharm. Sci. 82:80-86 (1993).
2. P. E. Luner and G. L. Amidon. Equilibrium and kinetic factors influencing bile sequestrant efficacy. Pharm. Res. 9:670-676 (1992).
3. P. E. Luner and G. L. Amidon. Description and simulation of a multiple mixing tank model to predict the effect of bile sequestrans on bile salt excretion. J. Pharm. Sci. 82:311-318 (1993).
4. P. Gillies, L. Grimminger, G. Figuly, J. Jensen, S. Royce, and E. Shimshick. DMP 504: A hydrogel bile acid sequestrant; part 1 - Equilibrium binding and kinetics. Abstract and presentation in XII International Symposium on Drugs Affecting Lipid Metabolism, 139 (1995).
5. J. Billheimer, R. Fischer, S. Germain, G. Figuly, J. Jensen, S. Royce, M. Gorko, J. Hainer, and P. Gillies. DMP 504: A hydrogel bile acid sequestrant; part 2 - Mechanism of action studies in the hamster. Abstract and presentation in XII International Symposium on Drugs Affecting Lipid Metabolism, 139 (1995).
6. K. S. Raghavan, R-K. Chang, J. Pang, G. Figuly, and M. A. Hussain. Physical and chemical properties of DMP 504, a polyalkylammonium-based bile acid sequestrant. Pharm. Dev. Tech. 2:233-241 (1997).