Protection against parenteral HIV-1 infection by homozygous deletion in the C-C chemokine receptor 5 gene

AIDS

Volumn 13, Issue 9, 1999, Pages 1025-1028

  Kupfer, Bernd ^b   Kaiser, Rolf ^a   Brackmann, Hans H ^b   Effenberger, Wolfgang ^b   Rockstroh, Jürgen K ^b   Matz, Bertfried ^b   Schneweis, Karl E ^b  

^a UNIVERSITY OF BONN   (Germany)

^b NONE

Author keywords

Bloodborne transmission; CCR5 deletion; Haemophilia; HIV 1

Indexed keywords

BETA CHEMOKINE; BLOOD CLOTTING FACTOR CONCENTRATE; CHEMOKINE RECEPTOR; DNA;

AGAR GEL ELECTROPHORESIS; ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENOTYPE; HEMOPHILIA; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RATE; INFECTION SENSITIVITY; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR GENE; VIRUS TRANSMISSION;

BASE SEQUENCE; CD4 LYMPHOCYTE COUNT; COHORT STUDIES; DNA; GENOTYPE; HEMOPHILIA A; HIV INFECTIONS; HIV-1; HUMANS; RECEPTORS, CCR5; RNA, VIRAL; SEQUENCE DELETION;

EID: 0032771759     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199906180-00004     Document Type: Article

References (18)

1. 1. Deng H, Liu R, Ellmeier W, et al. Identification of a major coreceptor for primary isolates of HIV-1. Nature 1996, 381:661-666.
2. 2. Dragic T, Litwin V, Allaway GP, et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996, 381:667-673.
3. 3. Alkhatib G, Combadiere C, Broder CC, et al. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996, 272:1955-1958.
4. 4. Choe H, Farzan M, Sun Y, et al. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996, 85:1135-1148.
5. 5. Doranz BJ, Rucker J, Yi Y, et al. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 1996, 85:1149-1158.
6. 6. Feng Y, Broder CC, Kennedy PE, Berger EA. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996, 272:872-877
7. 7. Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996, 86:367-377.
8. 8. Samson M, Libert F, Doranz BJ, et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996, 382:722-725.
9. 9. Dean M, Carrington M, Winkler C, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 1996, 273:1856-1862.
10. 10. Huang Y, Paxton WA, Wolinsky SM, et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nature Med 1996, 2:1240-1243.
11. 11. Biti R, Ffrench R, Young J, Bennets B, Stewart G, Liang T. HIV-1 infection in an individual homozygous for the CCR5 deletion. Nature Med 1997, 3:252-253.
12. 12. Theodorou I, Meyer L, Magierowska M, Katlama C, Rouzioux C. HIV-1 infection in an individual homozygous for CCR5 delta 32. Lancet 1997, 349:1219-1220.
13. 13. O'Brien TR, Winkler C, Dean M, et al. HIV-1 infection in a man homozygous for CCR5 delta 32. Lancet 1997, 349:1219.
14. 14. Kamradt T, Niese D, Schneweis KE, et al. Natural history of HIV-infection in hemophiliacs: clinical, immunological, and virological findings. Klin Wochenschr 1989, 67:1033-1041.
15. 15. Wilkinson DA, Operskalski EA, Busch MP, Mosley JW, Koup RA. A 32-bp deletion within the CCR5 locus protects against transmission of parenterally acquired human immunodeficiency virus but does not affect progression to AIDS-defining illness. J Infect Dis 1998, 178:1163-1166.
16. 16. Schneweis KE, Kleim JP, Bailly E, Niese D, Wagner N, Brackmann HH. Graded cytopathogenicity of the human immunodeficiency virus (HIV) in the course of HIV infection. Med Microbiol Immunol (Berl) 1990, 179:193-203.
17. 17. Kupfer B, Kaiser R, Rockstroh JK, Matz B, Schneweis KE. Role of HIV-1 phenotype in viral pathogenesis and its relation to viral load and CD4+ T-cell count. J Med Virol 1998, 56:259-263.
18. 18. Zagury D, Lachgar A, Chams V, et al. C-C chemokines, pivotal in protection against HIV type 1 infection. Proc Natl Acad Sci USA 1998, 95:3857-3861.