Pharmacokinetics and tolerance of flunitrazepam in neonates and in infants

Clinical Pharmacology and Therapeutics

Volumn 66, Issue 2, 1999, Pages 136-139

  Pariente Khayat, Ann ^b   Tréluyer, Jean Marc ^b   Rey, Elisabeth ^b   Mokhtari, Mostafa ^b   Werner, Evelyne ^b   Jouvet, Philippe ^b   D'Athis, Philippe ^b   Wood, Chantal ^b   Hubert, Philippe ^b   Hotellier, Françoise ^b   Olive, Georges ^b   Pons, Gérard ^a  

^a HÔPITAL SAINT VINCENT DE PAUL   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FLUNITRAZEPAM;

ARTICLE; CLINICAL ARTICLE; DIASTOLIC BLOOD PRESSURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG SAFETY; DRUG TOLERANCE; FEMALE; HUMAN; INFANT; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; SEDATION;

EID: 0032771448     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1053/cp.1999.v66.100596001     Document Type: Article

References (13)

1. 1. Haefely W, Cumin R, Kulcsar A, Polc P, Schaffner R. Einige aspekte der pharmakologie von Flunitrazepam ("Rohypnol"). In: Hügin W, Hossli G, Gemperlem M, editors. Bisherige Erfahrungen mit "Rohypnol" (Flunitrazepam) in der Anästhesiologie und Intensivtherapie. Basel: Editiones Roche; 1976. p. 13-26.
2. 2. Mattila MAK, Larni HM. Flunitrazepam: a review of its pharmacological properties and therapeutic use. Drugs 1980;20:353-74.
3. 3. Kanto J, Kangas L, Aaltonen L, Hilke H. Effect of age on the pharmacokinetics and sedative effect of flunitrazepam. Int J Clin Pharmacol TherToxicol 1981;19:400-4.
4. 4. Iisalo E, Kanto J, Aaltonen L, Mäkelä J. Flunitrazepam as an induction agent in children. Br J Anaesth 1984;56: 899-902.
5. 5. Boxenbaum HG, Posmanter HN, Macasieb T, Geitner KA, Weinfeld KE, Moore JD et al. Pharmacokinetics of flunitrazepam following single-and multiple-dose oral administration to healthy human subjects. J Pharm Biopharm 1978;6:283-93.
6. 6. Davis PJ, Cook DR. Clinical pharmacokinetics of the newer intravenous anaesthetic agents. Clin Pharmacokinet 1986;11:18-35.
7. 7. Hovi-Viander M, Aaltonen L, Kangas L, Kanto J. Flunitrazepam as an induction agent in elderly, poor-risk patients. Acta Anaesthesiol Scand 1982;26:507-10.
8. 8. Kangas L, Kanto J, Pakkanen A. A pharmacokinetic and pharmacodynamic study of flunitrazepam. Int J Clin Pharmacol Ther Toxicol 1982;20:585-8.
9. 9. Rey E, Nandakumaran M, Richard MO, Loose JP, d'Athis P, Saint-Maurice C, et al. Pharmacokinetics of flunitrazepam after single rectal administration in children. Dev Pharmacol Ther 1984;7:206-12.
10. 10. Gex-Fabry M, Balant LP. Considerations on data analysis using computer methods and currently available software for personal computers. In: Welling PG, Balant LP editors. Handbook of experimental pharmacology, pharmacokinetics of drugs; vol 110. Berlin: Springer-Verlag; 1994.
11. 11. Wickström E, Amrein R, Haefelfinger P, Hartmann D. Pharmacokinetic and clinical observations on prolonged administration of flunitrazepam. Eur J Clin Pharmacol 1980;17:189-96.
12. 12. Grahnen A, Wennerlund P, Dahlström B, Eckernäs SÅ. Inter-and intraindividual variability in the concentration-effect (sedation) relationship of flunitrazepam. Br J Clin Pharmacol 1991;31:89-92.
13. 13. Coleman A, Dowing J, Mayes D, O'Brien A. Acute cardiovascular effects of ROS-4200: a new anesthetic induction agent. S Afr Med J 1973;47:382-4.