Molecular aspects of fatty acid transport: Mutations in the IYTSGTTGXPK motif impair fatty acid transport protein function

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 60, Issue 5-6, 1999, Pages 285-289

  Stuhlsatz Krouper, S M ^a   Bennett, N E ^a   Schaffer, J E ^a,b  

^a Center for Cardiovascular Research   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; CARRIER PROTEIN; FATTY ACID TRANSPORTER; LONG CHAIN FATTY ACID; SERINE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FATTY ACID TRANSPORT; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS;

ANIMALIA; MAMMALIA; MURINAE;

EID: 0032771089     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-3278(99)80001-5     Document Type: Article

References (16)

1. 1. Neely J. R., Rovetto M. J., Oram J. F. Myocardial utilization of carbohydrate and lipids. Prog Cardiovasc Dis 1972; 15: 289-329.
2. 2. van der Vusse G. J., Glatz J. F., Stam H. C., Reneman R. S. Fatty acid homeostasis in the normoxic and ischemic heart. Physiol Rev 1992; 72: 881-940.
3. 3. Kelly D. P., and Strauss A. W. Mechanisms of disease: inherited cardiomyopathies. New Engl J Med 1994; 330: 913-919.
4. 4. Schaffert J. E., Lodish H. F. Expression cloning and characterization of a novel adipocyte long, chain fatty acid transport protein. Cell 1994; 79: 427-436.
5. 5. Hirsch D., Stahl A., Lodish H. F. A family of fatty acid transporters conserved from mycobacterium to man. Proc Natl Acad Sci USA 1988; 95: 8625-8629.
6. 6. Schaffer J. E., Lodish H. F. Molecular mechanism of long-chain fatty acid uptake. Trends Cardiovasc Med 1995; 5: 218-224.
7. 7. Stuhlsatz-Krouper S. M., Bennett N. E., Schaffer J. E. Substitution of alanine for serine 250 in the murine fatty acid transport protein inhibits long chain fatty acid transport. J Biol Chem 1988; 273: 28642-28650.
8. 8. Faergeman N. J., DiRusso C. C., Elberger A., Knudsen J., Black P. N. Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids. J Biol Chem 1997; 272: 8531-8538.
9. 9. Watkins P. A., Lu J.-F., Steinberg S. J., Gould S. J., Smith K. D., Braiterman L. T. Disruption of the Saccharomyces cerevisiae FAT1 gene decreases very long-chain fatty acyl-CoA synthetase activity and elevates intracellular very long-chain fatty acid concentrations. J Biol Chem 1998; 273: 18210-18219.
10. 10. Schaap F. G., Hamers L., Van der Vusse G. J., Glatz J. F. C. Molecular cloning of fatty acid-transport protein cDNA from rat. Biochim Biophys Acta 1997; 1354: 29-34.
11. 11. Walker J. E., Saraste M., Runswick M. J., Gay N. J. Distantly related sequences in the alpha-and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. Embo J 1982; 1: 945-951.
12. 12. Traut T. W. The functions and consensus motifs of nine types of peptide segments that form different types of nucleotide-binding sites. Eur J Biochem 1994; 222: 9-19.
13. 13. Ory D. S., Neugeboren B. A., Mulligan R. C. A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci USA 1996; 93: 11400-11406.
14. 14. Lacaperer J.-J., Garin J., Trinnaman B., Green N. M. Identification of amino acid residues photolabeled with 8-azidoadenosine 5′-diphosphate in the catalytic site of sarcoplasmic reticulum Ca-ATPase. Biochemistry 1993; 32: 3414-3421.
15. 15. Olcotti M. C., Bradley M. L., Haley B. E. Photoaffinity labeling of creatine kinase with 2-azido-and 8-azidoadenosine triphosphate: identification of two peptides from the ATP-binding domain. Biochemistry 1994; 33: 11935-11941.
16. 16. Thompson J. F., Geoghegan K. F., Lloyd D. B., Lanzetti A. J., Magyar R. A., Anderson S. M., Branchini B. R. Mutation of a protease-sensitive region in firefly luciferase alters light emission properties. J Biol Chem 1997; 272: 18766-18771.