Inhibition of System A amino acid transport and hepatocyte proliferation following partial hepatectomy in the rat

Hepatology

Volumn 30, Issue 2, 1999, Pages 437-444

  Freeman, Thomas L ^a   Ngo, Hao Q ^a   Mailliard, Mark E ^a,b,c  

^a TEXAS TECH UNIVERSITY   (United States)

^b UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 2 METHYLAMINOPROPIONIC ACID; AMINO ACID; EPIDERMAL GROWTH FACTOR;

AMINO ACID BLOOD LEVEL; AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CELL VOLUME; COMPETITIVE INHIBITION; DNA SYNTHESIS; FETAL CALF SERUM; LIVER CELL; LIVER REGENERATION; MALE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT;

ALANINE; AMINO ACID TRANSPORT SYSTEMS; AMINO ACIDS; ANIMALS; BETA-ALANINE; BETAINE; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL DIVISION; DNA; HEPATECTOMY; LIVER; LIVER REGENERATION; MALE; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN BIOSYNTHESIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032769677     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510300212     Document Type: Article

References (32)

1. Taub R. Liver regeneration in health and disease. Clin Lab Med 1996;16:341-360.
2. Michaopoulos GK, DeFrances MC. Liver regeneration. Science 1997;276: 60-66.
3. Grishman, JW. A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regeneration of rat liver. Cancer Res 1962;22:842-845.
4. Sips, HJ, Groen, AK, Tager JM. Plasmamembrane transport of alanine is ratelimiting for its metabolism in rat-liver parenchymal cells. FEES Lett 1980;119:271-274.
5. Stevens, BR, Kakuda DK, Yu K, Waters M, Vo CB, Raizada K. Induced nitric oxide synthesis is dependent on induced alternatively spliced CAT-2 encoding L-arginine transport in brain astrocytes. J Biol Chem 1996;271:24017-24022.
6. Fowler, FC, Banks RK, Mailliard ME. Characterization of sodium-dependent amino acid transport activity during liver regeneration. HEPATOLOGY 1992-.16:1187-1194.
7. Closs, EI, Borel Rinkes IHM, Bader A, Yarmush ML, Cunningham JM. Retroviral infection and expression of cationic amino acid transporters in rodent hepatocytes. J Virol 1993;67:2097-2102.
8. Aulak KS, Liu J, Wu J, Hyatt SL, Puppi M, Henning SJ, Hatzoglou M. Molecular sites of regulation of expression of the rat cationic amino acid transporter gene. J Biol Chem 1996;271:29799-297806.
9. Mailliard ME, Stevens BR, Mann GE. Amino acid transport by small intestinal, hepatic and pancreatic epithelia. Gastroenterology 1995;108: 888-910.
10. Short, J, Armstrong NB, Zemel R, Lieberman I. A role for amino acids in the induction of deoxyribonucleic acid synthesis in liver. Biochem Biophys Res Commun 1973;50:430-437.
11. McGowan J, Atryzek V, Fausto N. Effects of protein-deprivation on the regeneration of rat liver after partial hepatectomy. Biochem J 1979;180: 25-35.
12. Chiba T, Kawai K, Ikenaka K, Nakamura H, Okamoto M, Harada N, Tanaka H, et al. Effect of an exogenous energy source and amino acids on DNA synthesis in regenerating rat liver. Biochim Biophys Acta 1983;755: 420-427.
13. Haussinger D, Lang F. Cell volume in the regulation of hepatic function: a mechanism for metabolic control. Biochim Biophys Acta 1991;1071: 331-350.
14. Bussolati O, Uggeri J, Belletti S, Dall'Asta V, Gazzola GC. The stimulation of Na, K, Cl cotransport and of system A for neutral amino acid transport is a mechanism for cell volume increase during the cell cycle. FASEB J 1996;10:920-926.
15. Sander G, Pardee AB. Transport changes in synchronously growing CHO and L cells. J Cell Physiol 1972;80:267-272.
16. Shotwell MA, Jayme DW, Kilberg MS, Oxender DL. Neutral amino acid transport systems in Chinese hamster ovary cells. J Biol Chem 1980;256: 5422-5427.
17. Higgins GM, Anderson RM. Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931;12:186-202.
18. Scott DF, Reynolds RD, Pilot HC, Potter VR. Co-induction of the hepatic amino acid transport system and tyrosine amintransferase by theophylline, glucagon and dibutyryl-cyclic AMP in vivo. Life Sci 1970;9:1133-1140.
19. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K. Current protocols in molecular biology. New York: John Wiley and Sons, 1994:2.1.1-2.1.10.
20. Towbin HT, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedures and some applications. Proc Nat Acad Sci U S A 1979;76:4350-4354.
21. Kilberg MS. Measurement of amino acid transport by hepatocytes in suspension or monolayer culture. Methods Enzymol 1989;173:564-575.
22. Christensen HN, Cullen AM. Effects of non-metabolizable analogs on the distribution of amino acids in the rat. Biochim Biophys Acta 1968;150:237-252.
23. Tews JK, Harper AE. Food and protein intake, glucagon, and distribution of aminoisobutyrate in the rat. Am J Physiol 1980;238:E358-E363.
24. Bode B, Kilberg MS. Amino acid-dependent increase in hepatic system N activity is linked to cell swelling. J Biol Chem 1991;266:7376-7381.
25. Dall'Asta V, Rossi PA, Bussolati O, Gazzola GC. Response of human fibroblast to hypertonic stress: Cell shrinkage is counteracted by an enhanced active transport of amino acids. J Biol Chem 1994;269:10485-10491.
26. Christensen HN. Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev 1990;70:43-77.
27. Petronini PG, DeAngelis E, Borghetti AF, Wheeler KP. Osmotically inducible uptake of betaine via amino acid transport system A in SV-3T3 cells. Biochem J 1994;300:45-50.
28. Zhang F, Warskulat U, Wettstein M, Haussinger D. Identification of betaine as an osmolyte in rat liver macrophages (Kupffer cells). Gastroenterology 1996;110:1543-1552.
29. Bracy DS, Handlogten ME, Barber EF, Han HP, Kilberg MS. Cis-inhibition, trans-inhibition, and repression of hepatic amino acid transport mediated by system A: substrate specificity and other properties. J Biol Chem 1986;261:1514-1520.
30. Brand HS, Deutz NEP, Meijer AJ, Jorning GGA, Chamuleau RAFM. In vivo amino acid fluxes in regenerating liver after two-thirds hepatectomy in the rat. J Hepatol 1995;23:333-340.
31. +-ATPase gene in Chinese hamster ovary cells. Proc Natl Acad Sci U S A 1991;88:3416-3420.
32. vom Dahl S, Hallbrucker C, Lang F, Haussinger D. Regulation of cell volume in the perfused rat liver by hormones. Biochem J 1991;280:105-109.