Hepatoprotective properties in the rat of Mitracarpus scaber (Rubiaceae)

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 6, 1999, Pages 729-734

  Germano M P ^a   Sanogo, R ^a   Costa, C ^a   Fulco, R ^a   D'Angelo, V ^a   Torre, E A ^a   Viscomi, M G ^b   De Pasquale, R ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; FREE RADICAL; LACTATE DEHYDROGENASE; MITRACARPUS SCABER EXTRACT; PLANT EXTRACT; TETRAZOLIUM; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; ENZYME ACTIVITY; LIVER CELL; LIVER PROTECTION; MALE; NONHUMAN; RAT; SURVIVAL RATE;

ANIMALS; CARBON TETRACHLORIDE; FREE RADICAL SCAVENGERS; LIVER; MALE; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RUBIACEAE;

EID: 0032768913     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991772871     Document Type: Article

References (24)

1. Adjanohoun, E. J., Ahyi, A. M. R., Akè Assi, L., Chibon, P., Eyme, J., Garba, M., Gassita, J. N., Goudote, E., Giunko, S., Keita, A., Lò, I. (1986) Contribution aux ètudes ethnobotaniques et floristiques au Togo. ACCT Paris, pp 121-133
2. Adjanohoun, E. J., Ahyi, A. M. R., Akè Assi, L., Boukef, K., Gusset, G., Dramane. K., Eyme, J., Gassita, J. N., Goudote, E., Guinco, S., Lò, I., Keita, A., Kiniffo, H. V., Konè Bamba, D., Mùsampa Nseyya, A., Saadou, M. (1989) Contribution aux études ethnobotaniques et floristiques en Republique Populaire du Benin. ACCT Paris, pp 185-195
3. Bisignano, G., Sanogo, R., Aquino, R., D'Angelo, V., Germanò, M. P., De Pasquale, R., Pizza, C. (1998) Antibacterial and antimycotical activities of phenolic compounds from Mitracarpus scaber Zucc. Applied Microbiology in press
4. Boussenadji, R., Porthault, M., Berthod, A. (1993) Microbore liquid chromatography with electrochemical detection for the control of phenolic antioxidants in drugs and foods. J. Pharm. Biomed. Anal. 11: 71-78
5. Comporti, M. (1985) Lipid peroxidation and cellular damage in toxic liver injury. Lab. Invest. 53: 599-623
6. Drotman, R. B., Lawhorn, G. T. (1978) Serum enzymes as indicators of chemical induced liver damage. Drug Chem. Toxicol. 1: 163-171
7. Ekpendu, T. O., Akah, P. A., Adesomoju, A. A., Okogun, J. I. (1994) Antiinflammatory and antimicrobial activities of Mitracarpus scaber extracts. Int. J. Pharmacog. 32: 191-196
8. Fleurentin, J., Hoefler, C., Lexa, A., Mortier, F., Pelt, J. M. (1986) Hepatoprotective properties of Crepis rueppellii and Anisotes trisulcus: two traditional medicinal plants of Yemen. J. Ethnopharmacol. 16: 105-111
9. Irobi, O. N., Daramola, S. O. (1993) Antifungal activities of crude extracts of Mitracarpus villosus (Rubiaceae). J. Ethnopharmacol. 40: 137-140
10. Irobi, O. N., Daramola, S. O. (1994) Bactericidal properties of crude extracts of Mitracarpus villosus (Rubiaceae). J. Ethnopharmacol. 42: 39-43
11. Kerharo, J., Adam, J. G. (1974) Pharmacopée Sénégalaise Traditionelle: Plantes Médicinales et toxiques. Edit. Vigotfrères, Paris, pp 692-695
12. Kiso, Y., Tohkin, M., Hikino, H., Hattori, M., Sakamoto, T., Namba, T. (1984) Mechanism of antihepatotoxic activity of Glycyrrhizin, I: Effect on free radical generation and lipid peroxidation. Planta Medica 50: 293-302
13. Masaki, H., Atsumi, T., Sakurai, H. (1995) Peroxyl radical scavenging activities of hamamelitannin in chemical and biological systems. Free Radic. Res. 22: 419-430
14. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival. Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63
15. Ohnishi, M., Morishita, H., Iwahashi, H., Shizuo, T., Yoshiaki, S., Kimura, M., Kido, R. (1994) Inhibitory effects of chlorogenic acids on linoleic acid, peroxidation and haemolysis. Phytochemistry 36: 579-583
16. Recknagel, R. O. (1983) A new direction in the study of carbon tetrachloride hepatotoxicity. Life Sci. 33: 401-408
17. Recknagel, R. O., Glende, E. A. (1973) Carbon tetrachloride hepatotoxicity: an example of lethal cleavage. CRC Crit. Rev. Toxicol. 2: 263-297
18. Saija, A., Scalese, M., Lanza, M., Marzullo, D., Bonina, F., Castelli, F. (1995) Flavonoids as antioxidant: importance of their interaction with biomembranes. Free Radic. Biol. Med. 19: 481-486
19. Salah, N., Miller, N. J., Paganga, G., Tijburg, L., Bolwell, G. P., Rice-Evans, C. (1995) Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking anti-oxidants. Arch. Biochem. Biophys. 322: 339-346
20. Sanogo, R., Germanò, M. P., De Pasquale, R., Keita, A., Bisignano, G. (1996) Selective antimicrobial activities of Mitracarpus scaber Zucc. against Candida and Staphylococcus sp. Phytomedicine 2: 265-268
21. Seglen, P. O. (1973) Preparation of liver cells. Exp. Cell. Res. 82: 391-398
22. Seglen, P. O. (1976) Preparation of isolated liver cells. In: Prescott, D. M. (ed.) Methods in Cell Biology, Academic Press, New York, pp 30-78
23. Thabrew, M. I., Joice, P. D. T. M., Rajatissa, W. (1987) A comparative study of the efficacy of Pavetta indica and Osbeckia octandra in the treatment of liver dysfunction. Planta Medica 53: 239-241
24. Tyson, C. A., Hawk-Prather, K., Story, D. L., Gould, D. H. (1983) Correlation of in-vitro and in-vivo hepatotoxicity for five haloalkanes. Toxicol. Appl. Pharmacol. 70: 289-302