Muscle net glucose uptake and glucose kinetics after endurance training in men

American Journal of Physiology - Endocrinology and Metabolism

Volumn 277, Issue 1 40-1, 1999, Pages

  Bergman, B C ^a   Butterfield, G E ^b   Wolfel, E E ^c   Lopaschuk, G D ^d   Casazza, G A ^a   Horning, M A ^a   Brooks, G A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Crossover concept; Exertion; Glycogen; Lactate; Stable isotopes

Indexed keywords

GLUCOSE; GLYCOGEN;

ADULT; ARTICLE; ENDURANCE; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; GLYCOGENOLYSIS; HUMAN; HUMAN EXPERIMENT; MALE; MUSCLE METABOLISM; NORMAL HUMAN; OXYGEN CONSUMPTION; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; TRAINING;

EID: 0032768285     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.277.1.e81     Document Type: Article

References (38)

1. Ahlborg, G., and P. Felig. Lactate and glucose exchange across the forearm, legs, and splanchnic bed during and after prolonged exercise. J. Clin. Invest. 69: 45-54, 1982.
2. Bergman, B. C., G. E. Butterfield, E. E. Wolfel, G. A. Casazza, G. D. Lopaschuk, and G. A. Brooks. Evaluation of exercise and training on muscle lipid metabolism. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E106-E117, 1999.
3. Brooks, G. A. Physical activity and carbohydrate metabolism. In: Physical Activity, Fitness, and Health, edited by C. Bouchard, R. J. Shepard, and T. Stephens. Champaign, IL: Human Kinetics, 1994, p. 401-416.
4. Brooks, G. A., and C. M. Donovan. Effect of endurance training on glucose kinetics during exercise. Am. J. Physiol. 244 (Endocrinol. Metab. 7): E505-E512, 1983.
5. Brooks, G. A., and J. Mercier. Balance of carbohydrate and lipid utilization during exercise: the "crossover" concept. J. Appl. Physiol. 76: 2253-2261, 1994.
6. Brooks, G. A., and J. Trimmer. Glucose kinetics during high-intensity exercise and the crossover concept. J. Appl. Physiol. 80: 1073-1074, 1996.
7. Carraro, F., C. A. Stuart, W. H. Hartl, J. Rosenblatt, and R. R. Wolfe. Effect of exercise and recovery on muscle protein synthesis in human subjects. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E470-E476, 1990.
8. Coggan, A. R., W. M. Kohrt, R. J. Spina, D. M. Bier, and J. O. Holloszy. Endurance training decreases plasma glucose turn-over and oxidation during moderate-intensity exercise in men. J. Appl. Physiol. 68: 990-996, 1990.
9. Dela, F., K. J. Mikines, M. von Linstow, N. H. Secher, and H. Galbo. Effect of training on insulin-mediated glucose uptake in human muscle. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E1134-E1143, 1992.
10. 2 content. J. Appl. Physiol. 65: 473-477, 1988.
11. Foster-Powell, K., and J. B. Miller. International tables of glycemic index. Am. J. Clin. Nutr. 62: 871S-890S, 1995.
12. Frayn, K. N. Calculation of substrate oxidation rates in vivo from gaseous exchange. J. Appl. Physiol. 55: 628-634, 1983.
13. Friedlander, A. L., G. A. Casazza, M. A. Horning, M. J. Huie, M. F. Piacentini, J. K. Trimmer, and G. A. Brooks. Training-induced alterations in carbohydrate metabolism in women: women respond differently from men. J. Appl. Physiol. 80: 1175-1186, 1998.
14. Friedlander, A. L., G. A. Casazza, M. A. Horning, M. J. Huie, and G. A. Brooks. Training-induces alterations of glucose flux in men. J. Appl. Physiol. 82: 1360-1369, 1997.
15. Gutmann, I., and A. Wahlefeld. L-(+)-Lactate determination with lactate dehydrogenase and NAD. In: Methods of Enzymatic Analysis (2nd ed.), edited by H. Bergmeyer. New York: Academic, 1974, p. 1464-1468.
16. Henriksson, J. Training induced adaptation of skeletal muscle and metabolism during submaximal exercise. J. Physiol. (Lond.) 270: 661-675, 1977.
17. Hultman, E., and L. L. Spriet. Dietary intake prior to and during exercise. In: Exercise, Nutrition and Energy Metabolism, edited by E. S. Horton and R. L. Terjung. New York: Macmillan, 1988, p. 132-149.
18. Jackson, A., and M. Pollock. Generalized equations for predicting body density of men. Br. J. Nutr. 40: 497-504, 1978.
19. Jansson, E., P. Hjemdahl, and L. Kaijser. Epinephrine-induced changes in muscle carbohydrate metabolism during exercise in male subjects. J. Appl. Physiol. 60: 1466-1470, 1986.
20. Jansson, E., and L. Kaijser. Substrate utilization and enzymes in skeletal muscle of extremely endurance-trained men. J. Appl. Physiol. 62: 999-1005, 1987.
21. 2 into blood content. Respir. Physiol. 3: 111-115, 1967.
22. Kiens, B., B. Essen-Gustavsson, N. Christensen, and B. Saltin. Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training. J. Physiol. (Lond.) 469: 459-478, 1993.
23. Lopaschuk, G., D. Belke, J. Gamble, T. Itoi, and B. Schönekess. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim. Biophys. Acta 1213: 263-276, 1994.
24. Lopaschuk, G. D., C. A. Hansen, and J. R. Neely. Fatty acid metabolism in hearts containing elevated levels of CoA. Am. J. Physiol. 250 (Heart Circ. Physiol. 19): H351-H359, 1986.
25. Mendenhall, L. A., S. C. Swanson, D. L. Habash, and A. R. Coggan. Ten days of exercise training reduces glucose production and utilization during moderate-intensity exercise. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E136-E143, 1994.
26. Nunn, J. F. Nunn's Applied Respiratory Physiology. Boston: Butterworth-Heineman, 1993.
27. Odland, L. M., G. J. Heigenhauser, D. Wong, M. G. Hollidge-Horvat, and L. L. Spriet. Effects of increased fat availability on fat-carbohydrate interaction during prolonged exercise in men. Am. J. Physiol. 274 (Regulatory Integrative Comp. Physiol. 43): R894-R902, 1998.
28. Pendergrass, M., E. Fazioni, D. Collins, and R. A. De-Fronzo. IGF-I increases forearm blood flow without increasing forearm glucose. Am. J. Physiol. 275 (Endocrinol. Metab. 38): E345-E350, 1998.
29. Rennie, M. J., D. M. Park, and W. R. Sulaiman. Uptake and release of hormones and metabolites by tissues of exercising leg. Am. J. Physiol. 231: 967-973, 1976.
30. Richter, E. A., P. Jensen, B. Kiens, and S. Kristiansen. Sarcolemmal glucose transport and GLUT-4 translocation during exercise are diminished by endurance training. Am. J. Physiol. 274 (Endocrinol. Metab. 37): E89-E95, 1998.
31. Richter, E. A., B. Kiens, B. Saltin, N. J. Christensen, and G. Savard. Skeletal muscle glucose uptake during dynamic exercise in humans: role of muscle mass. Am. J. Physiol. 254 (Endocrinol. Metab. 17): E555-E561, 1988.
32. Roberts, A. C., J. T. Reeves, G. E. Butterfield, R. S. Mazzeo, J. R. Sutton, E. E. Wolfel, and G. A. Brooks. Altitude and β-blockade augment glucose utilization during submaximal exercise. J. Appl. Physiol. 80: 605-615, 1996.
33. Saltin, B., K. Nazar, D. Costill, E. Stein, E. Jansson, B. Essen, and P. Gollnick. The nature of the training response: peripheral and central adaptations to one-legged exercise. Acta Physiol. Scand. 96: 289-305, 1976.
34. Steinberg, H. O., G. Brechtel, A. Johnson, N. Fineberg, and A. D. Baron. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J. Clin. Invest. 94: 1172-1179, 1994.
35. Sumida, K. D., and C. M. Donovan. Endurance training fails to inhibit skeletal muscle glucose uptake during exercise. J. Appl. Physiol. 76: 1876-1881, 1994.
36. Turcotte, L. P., E. A. Richter, and B. Kiens. Increased plasma FFA uptake and oxidation during prolonged exercise in trained vs. untrained humans. Am. J. Physiol. 262 (Endocrinol. Metab. 25): E791-E799, 1992.
37. Wolfe, R. Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis. New York: Wiley-Liss, 1992.
38. Wolfel, E. E., B. M. Groves, G. A. Brooks, G. E. Butterfield, R. S. Mazzeo, L. G. Moore, J. R. Sutton, P. R. Bender, T. E. Dahms, R. E. McCullough, R. G. McCullough, S.-Y. Huang, S.-F. Sun, R. F. Grover, H. N. Hultgren, and J. T. Reeves. Oxygen transport during steady-state submaximal exercise in chronic hypoxia. J. Appl. Physiol. 70: 1129-1136, 1991.