Physicochemical properties and hemolytic effect of different lipid emulsion formulations using a mixture of emulsifiers

Pharmaceutica Acta Helvetiae

Volumn 73, Issue 6, 1999, Pages 293-301

  Jumaa, Muhannad ^a   Kleinebudde, Peter ^b   Müller, Bernd W ^a  

^a Gutenbergstr 76 24118 ^*  (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Cloud point; Emulsifier mixture; Hemolytic effect; Lipid emulsion; Physicochemical properties; Simplex lattice design

Indexed keywords

EMULSIFYING AGENT; LIPID EMULSION; PHOSPHATIDYLCHOLINE; POLYSORBATE 80; SYNPERONIC 68; UNCLASSIFIED DRUG;

ARTICLE; AUTOCLAVE; DISPERSION; DRUG FORMULATION; ERYTHROCYTE; HEMOLYSIS; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PARTICLE SIZE; PHYSICAL CHEMISTRY; ZETA POTENTIAL;

EID: 0032767950     PISSN: 00316865     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-6865(99)00003-5     Document Type: Article

References (25)

1. Bahadur P.S., Riess G. Block copolymers - a special class of surfactants. Tenside Surf. 28:1991;173-179.
2. Benita S., Friedman D., Weinstock M. Pharmacological evaluation of an injectable prolonged release emulsion of physostigmine in rabbits. J. Pharm. Pharmacol. 38:1986;653-658.
3. Bock T., Müller B.W. A novel assay to determine the hemolytic activity of drugs incorporated in colloidal carriers systems. Pharm. Res. 11:1994;589-591.
4. Chaturvedi R.P., Patel N.M., Lodhi S.A. Effect of terminal heat sterilization on the stability of phospholipid-stabilized submicron emulsions. Acta. Pharm. Nord. 4:1992;51-55.
5. Clint, J.H., 1988. Surfactant Aggregation. Blackie, New York, pp. 147-157.
6. Collins-Cold L.C., Lynos R.T., Bartholow L.C. Parenteral emulsions for drug delivery. Advanced Drug Delivery Review. 5:1990;189-209.
7. Cornell, J.A., 1990. Experiments with Mixtures. Wiley-Interscience, New York, pp. 21-98.
8. El-Hariri L.M., Marriot C., Martin G.P. The mitigating effects of phosphatidylcholines on bile salt - and lysophosphatidylcholine - induced membrane damage. J. Pharm. Pharmacol. 44:1992;651-654.
9. Forster D., Washington C., Daviss C.C. Toxicity of Solubilized and colloidal amphotericin B formulations to human erythrocytes. J. Pharm. Pharmacol. 40:1988;325-328.
10. Hailer S., Wolfram G. Influence of artificial fat emulsions on the composition of serum lipoproteins in human. Am. J. Clin. Nutr. 43:1986;225-233.
11. Hashida M., Takahashi Y., Muranishi S., Sezaki H. An application of water-in-oil and gelatin microsphere-in-oil emulsions to specific delivery of anticancer agents into stomach lymphatic. J. Pharmacokin. Biopharm. 5:1977;241-255.
12. Jeppsson R.I., Groves M.J., Yalabik H.S. The particle size distribution of emulsions containing diazepam for intravenous use. J. Clin. Pharmacol. 1:1976;123-127.
13. Jumaa M., Müller B.W. The stabilization of parenteral fat emulsion using non-ionic ABA copolymer surfactant. Int. J. Pharm. 174:1998;29-37.
14. Jumaa, M., Müller, B.W., 1998b. Influence of non-ionic surfactant PEG-660-12-hydroxy stearate on the surface properties of phospholipid monolayers and their effect on lipid emulsion stability. Colloid Polym. Sci., in press.
15. Jumaa M., Müller B.W. The effect of oil components and homogenization conditions on the physicochemical properties and stability of parenteral fat emulsions. Int. J. Pharm. 163:1998;81-89.
16. Kellner A., Correll J.W., Ladd A.T. Sustained hyperlipemia induced in rabbits by means of intravenously injected surface-active agents. J. Exp. Med. 93:1951;373-383.
17. Levy M.Y., Benita S. Design and characterization of a submicronized o/w emulsion of diazepam for parenteral use. Int. J. Pharm. 54:1989;103-112.
18. Magdassi S., Siman-Tov A. Formation and stabilization of perfluorocarbon emulsions. Int. J. Pharm. 59:1990;69-72.
19. Müller B.W. Die charakterisierung amphiphiler substanzen. Deutsche Apotheker Zeitung. 11:1978;404-409.
20. Rydhag L. The importance of the phase behaviour of phospholipids for emulsions stability. Fette. Seifen. Anstrichmittel. 81:1979;168-173.
21. Sayeed A.F., Tripp G.M., Sukumaran K.B., Mirkut B.A., Stelmach H.A., Raihle J.A. Stability of total nutrient admixtures using various intravenous fat emulsions. Am. J. Hosp. Pharm. 44:1987;2271-2280.
22. Yamaguchi T., Nishizaki K., Itai S., Hayashi H., Ohashima H. Physicochemical characterization of parenteral lipid emulsion: influence of cosurfactants on flocculation and coalescence. Pharm. Res. 12:1995;1273-1278.
23. Tamakura A., Ishii F., Noro S., Koishi M. Effect of homogenization conditions on the physicochemical properties of emulsion bases. Chem. Pharm. Bull. 31:1983;2786-2792.
24. Washington C. The stability of intravenous fat emulsions in total parenteral nutrition mixtures. Int. J. Pharm. 66:1990;1-21.
25. Weingarten C., Magalhaes N.S.S., Baszkin A., Benita S., Seiller M. Interaction of non-ionic ABA copolymer surfactant with phospholipid monolayers: possible relevance to emulsion stabilization. Int. J. Pharm. 75:1991;171-179.